STRINGSTRING
PTN PTN PTPN6 PTPN6 ENSCATP00000003834 ENSCATP00000003834 SRC SRC HDAC3 HDAC3 ROS1 ROS1 ENSCATP00000007407 ENSCATP00000007407 JAK3 JAK3 HIF1A HIF1A PRDM1 PRDM1 IRS1 IRS1 IL2RG IL2RG STAT3 STAT3 ENSCATP00000020093 ENSCATP00000020093 SIN3A SIN3A PLCG1 PLCG1 PIK3R2 PIK3R2 PIK3CB PIK3CB LOC105585293 LOC105585293 PIK3CA PIK3CA SHC1 SHC1 FRS2 FRS2 PIK3R1 PIK3R1 MYC MYC ALK ALK MYCN MYCN MDK MDK HDAC2 HDAC2 PTPRZ1 PTPRZ1 EP300 EP300 HDAC1 HDAC1 CD274 CD274 LTK LTK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTNPleiotrophin. (172 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
ENSCATP00000003834PTN_MK_N domain-containing protein. (60 aa)
SRCTyrosine-protein kinase. (644 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
ROS1Tyrosine-protein kinase receptor. (2345 aa)
ENSCATP00000007407PID domain-containing protein. (502 aa)
JAK3Tyrosine-protein kinase. (1124 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (831 aa)
PRDM1PR/SET domain 1. (825 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
IL2RGFibronectin type-III domain-containing protein. (369 aa)
STAT3Signal transducer and activator of transcription. (777 aa)
ENSCATP00000020093Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (433 aa)
SIN3ASIN3 transcription regulator family member A. (1273 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
PIK3R2Uncharacterized protein. (624 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
LOC105585293Uncharacterized protein. (290 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
SHC1SHC adaptor protein 1. (584 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
ALKTyrosine-protein kinase receptor. (1620 aa)
MYCNMYCN proto-oncogene, bHLH transcription factor. (464 aa)
MDKMidkine. (143 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2319 aa)
EP300E1A binding protein p300. (2411 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
CD274CD274 molecule. (290 aa)
LTKTyrosine-protein kinase receptor. (864 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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