45 items (Cercocebus atys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1236 aa)
	LOC105576630	Ig-like domain-containing protein; Belongs to the MHC class I family. (403 aa)
	SYK	Non-specific protein-tyrosine kinase. (637 aa)
	VAV3	Vav guanine nucleotide exchange factor 3. (875 aa)
	SPNS3	Sphingolipid transporter 3 (putative). (512 aa)
	ENSCATP00000003553	MHC_I-like_Ag-recog domain-containing protein. (170 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
	LCP2	Lymphocyte cytosolic protein 2. (533 aa)
	ERAS	ES cell expressed Ras. (233 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	ENSCATP00000007407	PID domain-containing protein. (502 aa)
	LOC105576712	Ig-like domain-containing protein; Belongs to the MHC class I family. (392 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
	GRAP2	GRB2 related adaptor protein 2. (330 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	KLRD1	Killer cell lectin like receptor D1. (179 aa)
	CD300LB	CD300 molecule like family member b. (238 aa)
	BTK	Tyrosine-protein kinase. (659 aa)
	LAT	Linker for activation of T cells. (270 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
	SIGLEC14	Sialic acid binding Ig like lectin 14. (396 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	PIK3R2	Uncharacterized protein. (624 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
	LOC105585293	Uncharacterized protein. (290 aa)
	TYROBP	TYRO protein tyrosine kinase binding protein. (144 aa)
	VAV2	Vav guanine nucleotide exchange factor 2. (868 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
	SHC1	SHC adaptor protein 1. (584 aa)
	CSDE1	Cold shock domain containing E1. (844 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	CLEC5A	C-type lectin domain containing 5A. (188 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	TREM1	Triggering receptor expressed on myeloid cells 1. (243 aa)
	CD300E	CD300e molecule. (205 aa)
	SIRPB1	Uncharacterized protein. (397 aa)
	SPNS1	Sphingolipid transporter 1 (putative). (571 aa)
	ENSCATP00000040590	Ig-like domain-containing protein. (295 aa)
	SIGLEC15	Sialic acid binding Ig like lectin 15. (328 aa)
	HLA-E	Major histocompatibility complex, class I, E; Belongs to the MHC class I family. (356 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	KLRK1	Killer cell lectin like receptor K1. (216 aa)
	LCK	Tyrosine-protein kinase. (540 aa)
	KLRC1	Killer cell lectin like receptor C1. (233 aa)

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	ENSCATP00000003553	ENSCATP00000012825	ENSCATP00000003553	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	MHC_I-like_Ag-recog domain-containing protein.	0.996
B2M	HLA-E	ENSCATP00000012825	ENSCATP00000042549	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Major histocompatibility complex, class I, E; Belongs to the MHC class I family.	0.979
B2M	KLRC1	ENSCATP00000012825	ENSCATP00000044423	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Killer cell lectin like receptor C1.	0.465
B2M	KLRD1	ENSCATP00000012825	ENSCATP00000016579	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Killer cell lectin like receptor D1.	0.689
B2M	LOC105576630	ENSCATP00000012825	ENSCATP00000001898	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.927
B2M	LOC105576712	ENSCATP00000012825	ENSCATP00000011398	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.886
B2M	TYROBP	ENSCATP00000012825	ENSCATP00000024777	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	TYRO protein tyrosine kinase binding protein.	0.424
BTK	ENSCATP00000007407	ENSCATP00000020405	ENSCATP00000007407	Tyrosine-protein kinase.	PID domain-containing protein.	0.402
BTK	FYN	ENSCATP00000020405	ENSCATP00000023367	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.497
BTK	GRAP2	ENSCATP00000020405	ENSCATP00000013424	Tyrosine-protein kinase.	GRB2 related adaptor protein 2.	0.712
BTK	GRB2	ENSCATP00000020405	ENSCATP00000042750	Tyrosine-protein kinase.	Growth factor receptor bound protein 2.	0.772
BTK	LAT	ENSCATP00000020405	ENSCATP00000021689	Tyrosine-protein kinase.	Linker for activation of T cells.	0.521
BTK	LCK	ENSCATP00000020405	ENSCATP00000043581	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.444
BTK	LCP2	ENSCATP00000020405	ENSCATP00000004225	Tyrosine-protein kinase.	Lymphocyte cytosolic protein 2.	0.970
BTK	LOC105585293	ENSCATP00000020405	ENSCATP00000024270	Tyrosine-protein kinase.	Uncharacterized protein.	0.402
BTK	PIK3CA	ENSCATP00000020405	ENSCATP00000027089	Tyrosine-protein kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.911
BTK	PIK3CB	ENSCATP00000020405	ENSCATP00000024233	Tyrosine-protein kinase.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.908
BTK	PIK3R1	ENSCATP00000020405	ENSCATP00000027907	Tyrosine-protein kinase.	Phosphoinositide-3-kinase regulatory subunit 1.	0.909
BTK	PIK3R2	ENSCATP00000020405	ENSCATP00000023918	Tyrosine-protein kinase.	Uncharacterized protein.	0.900
BTK	PLCG1	ENSCATP00000020405	ENSCATP00000022385	Tyrosine-protein kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.925