63 items (Cercocebus atys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
	CILP	Cartilage intermediate layer protein. (1184 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	FLT3	Fms related tyrosine kinase 3. (741 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
	ERAS	ES cell expressed Ras. (233 aa)
	ENSCATP00000005869	Uncharacterized protein. (526 aa)
	GAB1	GRB2 associated binding protein 1. (724 aa)
	ENSCATP00000007407	PID domain-containing protein. (502 aa)
	FGF3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
	KLB	Klotho beta. (1044 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1366 aa)
	SPEM2	SPEM family member 2. (505 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	IRS1	Insulin receptor substrate 1. (1241 aa)
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	GAB4	GRB2 associated binding protein family member 4. (536 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	THEM4	Thioesterase superfamily member 4. (240 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (534 aa)
	PTPN11	Protein tyrosine phosphatase non-receptor type 11. (552 aa)
	FGFR3	Fibroblast growth factor receptor. (809 aa)
	GAB2	GRB2 associated binding protein 2. (676 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	PIK3R2	Uncharacterized protein. (624 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
	LOC105585293	Uncharacterized protein. (290 aa)
	TRIB3	Tribbles pseudokinase 3. (385 aa)
	IRS4	Insulin receptor substrate 4. (1222 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
	SHC1	SHC adaptor protein 1. (584 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (522 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	FGFR2	Fibroblast growth factor receptor. (840 aa)
	IRS2	Insulin receptor substrate 2. (1338 aa)
	FGFR4	Fibroblast growth factor receptor. (802 aa)
	PDE3B	Phosphodiesterase. (1117 aa)
	PIK3R4	Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	CILP2	Cartilage intermediate layer protein 2. (1156 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	FGF22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (891 aa)
	TLR9	TIR domain-containing protein. (1033 aa)
	IGF2	Insulin like growth factor 2. (236 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	FGFR1	Fibroblast growth factor receptor. (820 aa)
	IGF1	Insulin like growth factor 1. (208 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	SPEM1	Spermatid maturation 1. (309 aa)
	FLT3LG	Fms related tyrosine kinase 3 ligand. (236 aa)
	ENSCATP00000044421	Uncharacterized protein. (441 aa)
	KL	Klotho. (1001 aa)
	FGF17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	FGF5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT2	IGF1	ENSCATP00000032050	ENSCATP00000041628	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin like growth factor 1.	0.413
AKT2	IRS1	ENSCATP00000032050	ENSCATP00000011875	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin receptor substrate 1.	0.617
AKT2	IRS2	ENSCATP00000032050	ENSCATP00000028907	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin receptor substrate 2.	0.459
AKT2	PDE3B	ENSCATP00000032050	ENSCATP00000030029	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphodiesterase.	0.897
AKT2	PDPK1	ENSCATP00000032050	ENSCATP00000018326	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	3-phosphoinositide dependent protein kinase 1.	0.977
AKT2	PIK3CA	ENSCATP00000032050	ENSCATP00000027089	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.943
AKT2	PIK3CB	ENSCATP00000032050	ENSCATP00000024233	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.939
AKT2	PIK3R1	ENSCATP00000032050	ENSCATP00000027907	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 1.	0.935
AKT2	PIK3R2	ENSCATP00000032050	ENSCATP00000023918	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.918
AKT2	THEM4	ENSCATP00000032050	ENSCATP00000017143	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Thioesterase superfamily member 4.	0.993
AKT2	TRIB3	ENSCATP00000032050	ENSCATP00000025085	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tribbles pseudokinase 3.	0.929
ENSCATP00000005869	ENSCATP00000007407	ENSCATP00000005869	ENSCATP00000007407	Uncharacterized protein.	PID domain-containing protein.	0.567
ENSCATP00000005869	ERAS	ENSCATP00000005869	ENSCATP00000004476	Uncharacterized protein.	ES cell expressed Ras.	0.417
ENSCATP00000005869	FGF1	ENSCATP00000005869	ENSCATP00000016793	Uncharacterized protein.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.412
ENSCATP00000005869	FGF18	ENSCATP00000005869	ENSCATP00000035596	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.455
ENSCATP00000005869	FGF19	ENSCATP00000005869	ENSCATP00000030962	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.437
ENSCATP00000005869	FGF3	ENSCATP00000005869	ENSCATP00000007994	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.445
ENSCATP00000005869	FGF4	ENSCATP00000005869	ENSCATP00000021933	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.445
ENSCATP00000005869	FGF5	ENSCATP00000005869	ENSCATP00000045960	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.442
ENSCATP00000005869	FGF7	ENSCATP00000005869	ENSCATP00000041058	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.407