STRINGSTRING
M6PR M6PR HGS HGS AP1B1 AP1B1 AP1M1 AP1M1 APP APP ENSCATP00000044134 ENSCATP00000044134 AP5M1 AP5M1 AP1G1 AP1G1 DNM2 DNM2 ENSCATP00000031565 ENSCATP00000031565 ZFYVE1 ZFYVE1 SULF1 SULF1 AP4M1 AP4M1 LOC105571822 LOC105571822 VAMP2 VAMP2 HSPA8 HSPA8 AP4S1 AP4S1 CLTB CLTB DNASE2B DNASE2B ENSCATP00000022722 ENSCATP00000022722 DNAJC6 DNAJC6 GNS GNS ENSCATP00000022027 ENSCATP00000022027 AP1S3 AP1S3 ENSCATP00000021227 ENSCATP00000021227 ARF1 ARF1 SULF2 SULF2 ENSCATP00000019466 ENSCATP00000019466 CHMP2A CHMP2A AP1G2 AP1G2 VAMP7 VAMP7 CLVS2 CLVS2 TXNDC5 TXNDC5 DNASE2 DNASE2 AP4E1 AP4E1 CLHC1 CLHC1 RSPH9 RSPH9 CLVS1 CLVS1 AP1S1 AP1S1 ZFYVE19 ZFYVE19 TBRG4 TBRG4 VAMP8 VAMP8 AP1M2 AP1M2 CTSZ CTSZ AP4B1 AP4B1 CLTA CLTA ENSCATP00000001293 ENSCATP00000001293 SH3GL2 SH3GL2 AP1S2 AP1S2 CLTC CLTC ARRB1 ARRB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
M6PRMannose-6-phosphate receptor, cation dependent. (278 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (786 aa)
AP1B1AP complex subunit beta. (949 aa)
AP1M1AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (435 aa)
APPAmyloid beta precursor protein. (770 aa)
ENSCATP00000044134AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (143 aa)
AP5M1Adaptor related protein complex 5 subunit mu 1; Belongs to the adaptor complexes medium subunit family. (495 aa)
AP1G1AP-1 complex subunit gamma. (744 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
ENSCATP00000031565Uncharacterized protein. (357 aa)
ZFYVE1Zinc finger FYVE-type containing 1. (797 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
AP4M1AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...] (453 aa)
LOC105571822Uncharacterized protein; Belongs to the heat shock protein 70 family. (534 aa)
VAMP2V-SNARE coiled-coil homology domain-containing protein. (118 aa)
HSPA8Uncharacterized protein. (129 aa)
AP4S1Adaptor related protein complex 4 subunit sigma 1. (158 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (211 aa)
DNASE2BDeoxyribonuclease 2 beta. (361 aa)
ENSCATP00000022722Uncharacterized protein; Belongs to the heat shock protein 70 family. (578 aa)
DNAJC6DnaJ heat shock protein family (Hsp40) member C6. (970 aa)
GNSGlucosamine (N-acetyl)-6-sulfatase. (584 aa)
ENSCATP00000022027Uncharacterized protein; Belongs to the heat shock protein 70 family. (594 aa)
AP1S3AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (164 aa)
ENSCATP00000021227Uncharacterized protein. (212 aa)
ARF1Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (181 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (950 aa)
ENSCATP00000019466Uncharacterized protein; Belongs to the heat shock protein 70 family. (621 aa)
CHMP2ACharged multivesicular body protein 2A. (222 aa)
AP1G2AP-1 complex subunit gamma. (785 aa)
VAMP7Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (220 aa)
CLVS2Clavesin 2. (327 aa)
TXNDC5Thioredoxin domain containing 5; Belongs to the protein disulfide isomerase family. (363 aa)
DNASE2Deoxyribonuclease 2, lysosomal. (360 aa)
AP4E1AP-4 complex subunit epsilon; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. (1125 aa)
CLHC1Clathrin heavy chain linker domain-containing protein 1. (586 aa)
RSPH9Radial spoke head 9 homolog. (295 aa)
CLVS1Clavesin 1. (354 aa)
AP1S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
ZFYVE19Zinc finger FYVE-type containing 19. (475 aa)
TBRG4Transforming growth factor beta regulator 4. (631 aa)
VAMP8Vesicle associated membrane protein 8. (100 aa)
AP1M2AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (419 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (303 aa)
AP4B1AP complex subunit beta; Belongs to the adaptor complexes large subunit family. (739 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (236 aa)
ENSCATP00000001293Uncharacterized protein; Belongs to the heat shock protein 70 family. (604 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (352 aa)
AP1S2AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
ARRB1Arrestin beta 1. (418 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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