STRINGSTRING
MAPKAP1 MAPKAP1 NCF1 NCF1 ACTG1 ACTG1 VAV3 VAV3 EFS EFS SRC SRC LOC105571986 LOC105571986 ENSCATP00000004469 ENSCATP00000004469 ERAS ERAS RASA1 RASA1 PTK2 PTK2 RHOA RHOA FNDC3B FNDC3B ACTRT1 ACTRT1 RNF222 RNF222 AKT1 AKT1 MAPK13 MAPK13 ENSCATP00000006855 ENSCATP00000006855 ACTL7A ACTL7A SH2D2A SH2D2A NCKAP1 NCKAP1 ACTL7B ACTL7B ELMO2 ELMO2 HSH2D HSH2D PRKCB PRKCB KDR KDR WASF2 WASF2 ENSCATP00000009637 ENSCATP00000009637 MAPK11 MAPK11 WASF1 WASF1 NEDD9 NEDD9 KRAS KRAS VEGFA VEGFA JUP JUP MLST8 MLST8 AXL AXL NCK1 NCK1 ENSCATP00000013162 ENSCATP00000013162 CAV1 CAV1 PRR5 PRR5 ACTB ACTB PRKCA PRKCA HRAS HRAS TGFB1I1 TGFB1I1 BRK1 BRK1 ROCK1 ROCK1 SH2D7 SH2D7 ITGB3 ITGB3 PAK1 PAK1 ENSCATP00000017084 ENSCATP00000017084 THEM4 THEM4 STX12 STX12 SHE SHE PDPK1 PDPK1 PTK2B PTK2B VAV1 VAV1 MAPKAPK3 MAPKAPK3 CYBB CYBB AKT3 AKT3 ENSCATP00000019657 ENSCATP00000019657 HSPB1 HSPB1 CASS4 CASS4 LPXN LPXN MAPK12 MAPK12 CTNNB1 CTNNB1 STX7 STX7 CDC42 CDC42 ELMO3 ELMO3 CYBA CYBA PLCG1 PLCG1 PRKCD PRKCD FYN FYN DOCK1 DOCK1 PIK3R2 PIK3R2 SHF SHF PIK3CB PIK3CB ACTL8 ACTL8 TRIB3 TRIB3 PRKCZ PRKCZ VAV2 VAV2 SHD SHD PIK3CA PIK3CA CSDE1 CSDE1 PAK3 PAK3 PIK3R1 PIK3R1 CYFIP2 CYFIP2 CDH5 CDH5 SHB SHB WASF3 WASF3 ITGAV ITGAV ITPR3 ITPR3 ITPR2 ITPR2 BCAR1 BCAR1 ABI2 ABI2 NCK2 NCK2 NCF4 NCF4 AKT2 AKT2 PAK2 PAK2 MAPKAPK2 MAPKAPK2 NCKAP1L NCKAP1L CTNNA1 CTNNA1 SPHK1 SPHK1 ARVCF ARVCF LOC105579900 LOC105579900 ELMO1 ELMO1 CTNND1 CTNND1 CYFIP1 CYFIP1 AHCYL1 AHCYL1 NOS3 NOS3 MTOR MTOR NRAS NRAS ITPR1 ITPR1 HSP90AA1 HSP90AA1 CRK CRK MAPK14 MAPK14 BAIAP2 BAIAP2 PRKACB PRKACB ENSCATP00000039367 ENSCATP00000039367 NCF2 NCF2 RICTOR RICTOR LOC105573641 LOC105573641 ROCK2 ROCK2 ENSCATP00000042801 ENSCATP00000042801 FNDC3A FNDC3A PRKACA PRKACA ENSCATP00000044372 ENSCATP00000044372 PXN PXN ABI1 ABI1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPKAP1MAPK associated protein 1. (522 aa)
NCF1Neutrophil cytosolic factor 1. (423 aa)
ACTG1Actin gamma 1. (377 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
EFSEmbryonal Fyn-associated substrate. (561 aa)
SRCTyrosine-protein kinase. (644 aa)
LOC105571986Uncharacterized protein. (189 aa)
ENSCATP00000004469Uncharacterized protein. (191 aa)
ERASES cell expressed Ras. (233 aa)
RASA1RAS p21 protein activator 1. (1051 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1068 aa)
RHOARas homolog family member A. (193 aa)
FNDC3BFibronectin type III domain containing 3B. (1158 aa)
ACTRT1Actin related protein T1; Belongs to the actin family. (375 aa)
RNF222Ring finger protein 222. (220 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
ENSCATP00000006855Uncharacterized protein. (519 aa)
ACTL7AActin like 7A; Belongs to the actin family. (435 aa)
SH2D2ASH2 domain containing 2A. (371 aa)
NCKAP1NCK associated protein 1. (1134 aa)
ACTL7BActin like 7B; Belongs to the actin family. (415 aa)
ELMO2Engulfment and cell motility 2. (720 aa)
HSH2DHematopoietic SH2 domain containing. (352 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
WASF2WASP family member 2. (498 aa)
ENSCATP00000009637Uncharacterized protein. (61 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
WASF1WASP family member 1. (559 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (839 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (409 aa)
JUPJunction plakoglobin. (745 aa)
MLST8MTOR associated protein, LST8 homolog. (335 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
NCK1Cytoplasmic protein. (377 aa)
ENSCATP00000013162Uncharacterized protein. (173 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
PRR5Proline rich 5. (410 aa)
ACTBUncharacterized protein. (375 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (467 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1337 aa)
SH2D7SH2 domain containing 7. (456 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
ENSCATP00000017084Uncharacterized protein. (185 aa)
THEM4Thioesterase superfamily member 4. (240 aa)
STX12Syntaxin 12; Belongs to the syntaxin family. (276 aa)
SHESrc homology 2 domain containing E. (495 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (534 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
VAV1Vav guanine nucleotide exchange factor 1. (856 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (411 aa)
CYBBCytochrome b-245 beta chain. (468 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSCATP00000019657Uncharacterized protein; Belongs to the actin family. (368 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
CASS4Cas scaffold protein family member 4. (786 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (386 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
CTNNB1Catenin beta 1. (781 aa)
STX7Syntaxin 7; Belongs to the syntaxin family. (261 aa)
CDC42Uncharacterized protein. (191 aa)
ELMO3Engulfment and cell motility 3. (763 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (195 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
FYNTyrosine-protein kinase. (537 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1886 aa)
PIK3R2Uncharacterized protein. (624 aa)
SHFSrc homology 2 domain containing F. (424 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
ACTL8Actin like 8; Belongs to the actin family. (386 aa)
TRIB3Tribbles pseudokinase 3. (385 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
VAV2Vav guanine nucleotide exchange factor 2. (868 aa)
SHDSrc homology 2 domain containing transforming protein D. (340 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
CSDE1Cold shock domain containing E1. (844 aa)
PAK3P21 (RAC1) activated kinase 3. (580 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (785 aa)
SHBSH2 domain containing adaptor protein B. (509 aa)
WASF3WASP family member 3. (502 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2568 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
ABI2Abl interactor 2. (513 aa)
NCK2Cytoplasmic protein. (382 aa)
NCF4Neutrophil cytosolic factor 4. (366 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
NCKAP1LNCK associated protein 1 like. (1060 aa)
CTNNA1Catenin alpha 1. (906 aa)
SPHK1Sphingosine kinase 1. (470 aa)
ARVCFARVCF delta catenin family member. (962 aa)
LOC105579900Uncharacterized protein. (319 aa)
ELMO1Engulfment and cell motility 1. (727 aa)
CTNND1Catenin delta 1. (971 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1239 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (530 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2745 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (831 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
BAIAP2BAI1 associated protein 2. (561 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
ENSCATP00000039367Uncharacterized protein. (360 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1732 aa)
LOC105573641Uncharacterized protein; Belongs to the actin family. (323 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
ENSCATP00000042801Uncharacterized protein. (136 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
ENSCATP00000044372Uncharacterized protein. (731 aa)
PXNPaxillin. (1082 aa)
ABI1Abl interactor 1. (508 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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