STRINGSTRING
TRAF2 TRAF2 ENSCATP00000000117 ENSCATP00000000117 ENSCATP00000000678 ENSCATP00000000678 TJP2 TJP2 DFFB DFFB LOC105595720 LOC105595720 HMGB4 HMGB4 ENSCATP00000001361 ENSCATP00000001361 NAIP NAIP ENSCATP00000001452 ENSCATP00000001452 SFN SFN FNTA FNTA PLEC PLEC GSN GSN MAPK8 MAPK8 PSMB11 PSMB11 ENSCATP00000003010 ENSCATP00000003010 PSMA7 PSMA7 ENSCATP00000003364 ENSCATP00000003364 ENSCATP00000003394 ENSCATP00000003394 CHMP6 CHMP6 ENSCATP00000003644 ENSCATP00000003644 ENSCATP00000003774 ENSCATP00000003774 ITCH ITCH ENSCATP00000004066 ENSCATP00000004066 PSMA1 PSMA1 BAX BAX CHMP7 CHMP7 BIRC7 BIRC7 HMGB2 HMGB2 H1-5 H1-5 DNM1L DNM1L PSMF1 PSMF1 ENSCATP00000004934 ENSCATP00000004934 PTK2 PTK2 HMGB1 HMGB1 UBE2L5 UBE2L5 LOC105595225 LOC105595225 CASP9 CASP9 NMT1 NMT1 H1-0 H1-0 LOC105576738 LOC105576738 VIM VIM H1-4 H1-4 LOC105588083 LOC105588083 AKT1 AKT1 PSMC3 PSMC3 ADD1 ADD1 LOC105589984 LOC105589984 LOC105579396 LOC105579396 DCC DCC LOC105595668 LOC105595668 ENSCATP00000007583 ENSCATP00000007583 CASP7 CASP7 TICAM2 TICAM2 YWHAQ YWHAQ TMEM198 TMEM198 PSMD7 PSMD7 TTC6 TTC6 YWHAZ YWHAZ ENSCATP00000008212 ENSCATP00000008212 PSMB8 PSMB8 BIRC3 BIRC3 DSG3 DSG3 STK24 STK24 BOK BOK TNFRSF10A TNFRSF10A CASP3 CASP3 PSMA2 PSMA2 ENSCATP00000010732 ENSCATP00000010732 ARHGAP10 ARHGAP10 GAS2 GAS2 LMNTD2 LMNTD2 DBNL DBNL XIAP XIAP ENSCATP00000011232 ENSCATP00000011232 SDCBP SDCBP MAPK3 MAPK3 HP1BP3 HP1BP3 ENSCATP00000011745 ENSCATP00000011745 TRADD TRADD ENSCATP00000011808 ENSCATP00000011808 ENSCATP00000011971 ENSCATP00000011971 PSMD6 PSMD6 ENSCATP00000012820 ENSCATP00000012820 STUB1 STUB1 PSMD4 PSMD4 CD14 CD14 ENSCATP00000013533 ENSCATP00000013533 APC APC PSMC6 PSMC6 GSDMB GSDMB HMGB3 HMGB3 LMNTD1 LMNTD1 CASP1 CASP1 DYNLL2 DYNLL2 ENSCATP00000014541 ENSCATP00000014541 PELI1 PELI1 LOC105595226 LOC105595226 PSMB3 PSMB3 ENSCATP00000015253 ENSCATP00000015253 ENSCATP00000015286 ENSCATP00000015286 CFLAR CFLAR ROCK1 ROCK1 MAPK1 MAPK1 FLOT2 FLOT2 ENSCATP00000016334 ENSCATP00000016334 ENSCATP00000016481 ENSCATP00000016481 ENSCATP00000016559 ENSCATP00000016559 UBA52 UBA52 CDC37 CDC37 BID BID DIABLO DIABLO LOC105579883 LOC105579883 STAT3 STAT3 APIP APIP CASP12 CASP12 PSMB10 PSMB10 IL1B IL1B SEPTIN4 SEPTIN4 RIPK1 RIPK1 PSMD12 PSMD12 BAD BAD PRKN PRKN PSMA5 PSMA5 CASP5 CASP5 PSMD10 PSMD10 LMNB2 LMNB2 CHMP2A CHMP2A AKT3 AKT3 LMNA LMNA SCIN SCIN CASP6 CASP6 PSMB7 PSMB7 ENSCATP00000020255 ENSCATP00000020255 ENSCATP00000020357 ENSCATP00000020357 PSMC5 PSMC5 DAPK1 DAPK1 ENSCATP00000021172 ENSCATP00000021172 CASP4 CASP4 PSME1 PSME1 FASLG FASLG BCL2L1 BCL2L1 CTNNB1 CTNNB1 PSMD9 PSMD9 PRKCQ PRKCQ LOC105588756 LOC105588756 DSP DSP LMNB1 LMNB1 PRKCD PRKCD TJP1 TJP1 DSG1 DSG1 ENSCATP00000023795 ENSCATP00000023795 CAPG CAPG FADD FADD TFDP2 TFDP2 PKP1 PKP1 MDP1 MDP1 ENSCATP00000024481 ENSCATP00000024481 CHMP3 CHMP3 TP63 TP63 LY96 LY96 STK26 STK26 PSMB1 PSMB1 PPP3R1 PPP3R1 BMF BMF IRF1 IRF1 LOC105589886 LOC105589886 BCL2L10 BCL2L10 OCLN OCLN CASP8 CASP8 UNC5A UNC5A KPNB1 KPNB1 OPA1 OPA1 PSMD2 PSMD2 SEPTIN1 SEPTIN1 GSDME GSDME GZMB GZMB PSMD1 PSMD1 ENSCATP00000028876 ENSCATP00000028876 PSMD8 PSMD8 ENSCATP00000029075 ENSCATP00000029075 PSMA6 PSMA6 ENSCATP00000029366 ENSCATP00000029366 ENSCATP00000029662 ENSCATP00000029662 TP73 TP73 TICAM1 TICAM1 BCAP29 BCAP29 PSMC1 PSMC1 MAPT MAPT AVEN AVEN TJP3 TJP3 SPTAN1 SPTAN1 APPL1 APPL1 SH3GLB2 SH3GLB2 ENSCATP00000031033 ENSCATP00000031033 BAK1 BAK1 YWHAG YWHAG PSMB2 PSMB2 TNFRSF10B TNFRSF10B TP53 TP53 AKT2 AKT2 PSMB4 PSMB4 OMA1 OMA1 ENSCATP00000032552 ENSCATP00000032552 BIRC2 BIRC2 PSMA3 PSMA3 PAK2 PAK2 E2F1 E2F1 PPP3CC PPP3CC GSDMD GSDMD PDCD6IP PDCD6IP PSMC2 PSMC2 PSMA8 PSMA8 KPNA1 KPNA1 APPL2 APPL2 ENSCATP00000034742 ENSCATP00000034742 ENSCATP00000034768 ENSCATP00000034768 SH3GLB1 SH3GLB1 ENSCATP00000035052 ENSCATP00000035052 ENSCATP00000035134 ENSCATP00000035134 SEPTIN5 SEPTIN5 H1-8 H1-8 SATB1 SATB1 IL1A IL1A YWHAB YWHAB ELANE ELANE PSMD3 PSMD3 UACA UACA IGDCC3 IGDCC3 C1QBP C1QBP UNC5B UNC5B ENSCATP00000037470 ENSCATP00000037470 PSMB6 PSMB6 CDH1 CDH1 ENSCATP00000037714 ENSCATP00000037714 HSP90AA1 HSP90AA1 PSMA4 PSMA4 DAPK3 DAPK3 PSMB9 PSMB9 IGDCC4 IGDCC4 ENSCATP00000038453 ENSCATP00000038453 NPVF NPVF PSMD13 PSMD13 LOC105587074 LOC105587074 DFFA DFFA TFDP1 TFDP1 RIPK3 RIPK3 PSMC4 PSMC4 PSMD14 PSMD14 MLKL MLKL YWHAE YWHAE YWHAH YWHAH ENSCATP00000040310 ENSCATP00000040310 FAS FAS ENSCATP00000040576 ENSCATP00000040576 APC2 APC2 MAP2 MAP2 APAF1 APAF1 LOC105571593 LOC105571593 BCL2L11 BCL2L11 BCAP31 BCAP31 ENSCATP00000041490 ENSCATP00000041490 ENSCATP00000041581 ENSCATP00000041581 RPS27A RPS27A TLR4 TLR4 OGT OGT ENSCATP00000042056 ENSCATP00000042056 PSME3 PSME3 PSMD11 PSMD11 MAPK10 MAPK10 DAPK2 DAPK2 PPP1R13B PPP1R13B CHMP2B CHMP2B IL18 IL18 CHMP4C CHMP4C ENSCATP00000042857 ENSCATP00000042857 ENSCATP00000042870 ENSCATP00000042870 BCL2 BCL2 CLSPN CLSPN PSMB5 PSMB5 CHMP4B CHMP4B PSMD5 PSMD5 FLOT1 FLOT1 CARD18 CARD18 ENSCATP00000043644 ENSCATP00000043644 BMX BMX ACIN1 ACIN1 BNIP5 BNIP5 STK25 STK25 DYNLL1 DYNLL1 PSME2 PSME2 PSME4 PSME4 DSG2 DSG2 ENSCATP00000045432 ENSCATP00000045432 TNFSF10 TNFSF10 TP53BP2 TP53BP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
ENSCATP00000000117Uncharacterized protein. (93 aa)
ENSCATP00000000678Uncharacterized protein. (211 aa)
TJP2Uncharacterized protein; Belongs to the MAGUK family. (1247 aa)
DFFBDNA fragmentation factor subunit beta. (337 aa)
LOC105595720Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
HMGB4High mobility group box 4. (191 aa)
ENSCATP00000001361DUF4203 domain-containing protein. (100 aa)
NAIPNLR family apoptosis inhibitory protein. (1403 aa)
ENSCATP00000001452Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (98 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
FNTAFarnesyltransferase, CAAX box, alpha. (379 aa)
PLECPlectin. (4684 aa)
GSNGelsolin. (809 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
PSMB11Proteasome subunit beta. (300 aa)
ENSCATP00000003010Uncharacterized protein. (189 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
ENSCATP0000000336414_3_3 domain-containing protein; Belongs to the 14-3-3 family. (217 aa)
ENSCATP00000003394Transcription factor. (393 aa)
CHMP6Charged multivesicular body protein 6. (214 aa)
ENSCATP00000003644ANK_REP_REGION domain-containing protein. (116 aa)
ENSCATP00000003774Uncharacterized protein. (291 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
ENSCATP00000004066Uncharacterized protein. (189 aa)
PSMA1Proteasome subunit alpha type. (269 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
CHMP7Charged multivesicular body protein 7. (453 aa)
BIRC7Baculoviral IAP repeat containing 7. (328 aa)
HMGB2Uncharacterized protein. (206 aa)
H1-5Histone cluster 1 H1 family member b. (226 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (802 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
ENSCATP00000004934ATPase_AAA_core domain-containing protein; Belongs to the AAA ATPase family. (177 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1068 aa)
HMGB1High mobility group box 1. (215 aa)
UBE2L5Ubiquitin conjugating enzyme E2 L5; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
LOC105595225FIIND domain-containing protein. (515 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (416 aa)
NMT1Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family. (543 aa)
H1-0H1 histone family member 0. (194 aa)
LOC105576738Ubiquitin-like domain-containing protein. (134 aa)
VIMVimentin; Belongs to the intermediate filament family. (466 aa)
H1-4Histone cluster 1 H1 family member e. (219 aa)
LOC105588083Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PSMC3AAA domain-containing protein; Belongs to the AAA ATPase family. (439 aa)
ADD1Adducin 1. (768 aa)
LOC105589984Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC105579396Ubiquitin-like domain-containing protein. (156 aa)
DCCDCC netrin 1 receptor. (1447 aa)
LOC105595668Ubiquitin-like domain-containing protein. (126 aa)
ENSCATP00000007583Uncharacterized protein. (188 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (336 aa)
TICAM2Toll like receptor adaptor molecule 2. (235 aa)
YWHAQ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (248 aa)
TMEM198Transmembrane protein 198. (360 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
TTC6TPR_REGION domain-containing protein. (1886 aa)
YWHAZ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa)
ENSCATP00000008212Uncharacterized protein. (145 aa)
PSMB8Proteasome subunit beta. (276 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
DSG3Desmoglein 3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (999 aa)
STK24Serine/threonine kinase 24. (417 aa)
BOKBCL2 family apoptosis regulator BOK. (212 aa)
TNFRSF10ATNF receptor superfamily member 10a. (471 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
ENSCATP00000010732CSN8_PSD8_EIF3K domain-containing protein. (249 aa)
ARHGAP10Rho GTPase activating protein 10. (786 aa)
GAS2Growth arrest specific 2. (314 aa)
LMNTD2Lamin tail domain containing 2. (634 aa)
DBNLDrebrin like. (440 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
ENSCATP00000011232UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (148 aa)
SDCBPSyndecan binding protein. (318 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
HP1BP3Heterochromatin protein 1 binding protein 3. (521 aa)
ENSCATP00000011745AAA domain-containing protein. (410 aa)
TRADDTNFRSF1A associated via death domain. (308 aa)
ENSCATP00000011808Ubiquitin-like domain-containing protein. (130 aa)
ENSCATP00000011971Uncharacterized protein. (191 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (442 aa)
ENSCATP0000001282014_3_3 domain-containing protein; Belongs to the 14-3-3 family. (208 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (363 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (374 aa)
ENSCATP00000013533Uncharacterized protein. (215 aa)
APCAPC regulator of WNT signaling pathway. (2861 aa)
PSMC6AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa)
GSDMBGasdermin B. (370 aa)
HMGB3Uncharacterized protein. (210 aa)
LMNTD1Lamin tail domain containing 1. (413 aa)
CASP1Caspase 1; Belongs to the peptidase C14A family. (441 aa)
DYNLL2Dynein light chain. (89 aa)
ENSCATP00000014541Prot_ATP_ID_OB domain-containing protein. (172 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
LOC105595226FIIND domain-containing protein. (349 aa)
PSMB3Proteasome subunit beta. (205 aa)
ENSCATP00000015253AAA domain-containing protein. (373 aa)
ENSCATP00000015286PDZ domain-containing protein. (251 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1337 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (505 aa)
ENSCATP00000016334Uncharacterized protein. (338 aa)
ENSCATP00000016481AAA domain-containing protein. (370 aa)
ENSCATP00000016559PDZ domain-containing protein. (294 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
CDC37Cell division cycle 37. (378 aa)
BIDBH3 interacting domain death agonist. (244 aa)
DIABLOUncharacterized protein. (239 aa)
LOC105579883Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (238 aa)
STAT3Signal transducer and activator of transcription. (777 aa)
APIPMethylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. (249 aa)
CASP12Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. (408 aa)
PSMB10Proteasome subunit beta. (273 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
SEPTIN4Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (985 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
BADBCL2 associated agonist of cell death. (167 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
CASP5Caspase 5; Belongs to the peptidase C14A family. (355 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
LMNB2Lamin B2; Belongs to the intermediate filament family. (621 aa)
CHMP2ACharged multivesicular body protein 2A. (222 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (728 aa)
SCINScinderin. (706 aa)
CASP6Caspase 6; Belongs to the peptidase C14A family. (293 aa)
PSMB7Proteasome subunit beta. (277 aa)
ENSCATP00000020255Dynein light chain. (83 aa)
ENSCATP00000020357AAA domain-containing protein; Belongs to the AAA ATPase family. (414 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
DAPK1Death associated protein kinase 1. (1440 aa)
ENSCATP00000021172Uncharacterized protein. (278 aa)
CASP4Caspase 4; Belongs to the peptidase C14A family. (377 aa)
PSME1Proteasome activator subunit 1. (249 aa)
FASLGTumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa)
BCL2L1BCL2 like 1. (233 aa)
CTNNB1Catenin beta 1. (781 aa)
PSMD9PDZ domain-containing protein. (223 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
LOC105588756Caspase recruitment domain family member 17. (110 aa)
DSPDesmoplakin. (2272 aa)
LMNB1Lamin B1; Belongs to the intermediate filament family. (586 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1742 aa)
DSG1Desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (938 aa)
ENSCATP0000002379514_3_3 domain-containing protein; Belongs to the 14-3-3 family. (238 aa)
CAPGCapping actin protein, gelsolin like. (348 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
TFDP2Transcription factor. (446 aa)
PKP1Plakophilin 1. (744 aa)
MDP1Magnesium dependent phosphatase 1. (164 aa)
ENSCATP00000024481Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (95 aa)
CHMP3Charged multivesicular body protein 3. (221 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (681 aa)
LY96Lymphocyte antigen 96. (160 aa)
STK26Serine/threonine kinase 26. (438 aa)
PSMB1Proteasome subunit beta. (241 aa)
PPP3R1Uncharacterized protein. (189 aa)
BMFBcl2 modifying factor. (184 aa)
IRF1Interferon regulatory factor. (325 aa)
LOC105589886Uncharacterized protein. (339 aa)
BCL2L10Uncharacterized protein. (194 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (505 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (515 aa)
UNC5AUnc-5 netrin receptor A. (898 aa)
KPNB1Karyopherin subunit beta 1. (876 aa)
OPA1OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1015 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
SEPTIN1Septin 1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (403 aa)
GSDMEGasdermin E. (495 aa)
GZMBGranzyme B; Belongs to the peptidase S1 family. (281 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
ENSCATP00000028876Uncharacterized protein. (89 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (350 aa)
ENSCATP00000029075IRF tryptophan pentad repeat domain-containing protein. (140 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
ENSCATP00000029366Uncharacterized protein. (101 aa)
ENSCATP00000029662Uncharacterized protein. (305 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
TICAM1Toll like receptor adaptor molecule 1. (519 aa)
BCAP29B cell receptor associated protein 29. (317 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
MAPTMicrotubule-associated protein. (776 aa)
AVENApoptosis and caspase activation inhibitor. (355 aa)
TJP3Tight junction protein 3; Belongs to the MAGUK family. (917 aa)
SPTAN1Spectrin alpha, non-erythrocytic 1. (2498 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (715 aa)
SH3GLB2SH3 domain containing GRB2 like, endophilin B2. (404 aa)
ENSCATP00000031033Ubiquitin-like domain-containing protein. (149 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
PSMB2Proteasome subunit beta. (201 aa)
TNFRSF10BTNF receptor superfamily member 10b. (445 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (274 aa)
OMA1OMA1 zinc metallopeptidase. (524 aa)
ENSCATP00000032552Cytochrome c domain-containing protein; Belongs to the cytochrome c family. (109 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
E2F1E2F transcription factor 1. (437 aa)
PPP3CCSerine/threonine-protein phosphatase. (438 aa)
GSDMDGasdermin D. (532 aa)
PDCD6IPProgrammed cell death 6 interacting protein. (873 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (465 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
KPNA1Importin subunit alpha; Functions in nuclear protein import. (538 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (664 aa)
ENSCATP00000034742JAB_MPN domain-containing protein. (166 aa)
ENSCATP00000034768Ubiquitin-like domain-containing protein. (144 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (402 aa)
ENSCATP00000035052Uncharacterized protein. (211 aa)
ENSCATP00000035134Ubiquitin-like domain-containing protein. (146 aa)
SEPTIN5Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (378 aa)
H1-8H1 histone family member O oocyte specific. (338 aa)
SATB1DNA-binding protein SATB. (794 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (271 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (263 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
UACAUveal autoantigen with coiled-coil domains and ankyrin repeats. (1418 aa)
IGDCC3Immunoglobulin superfamily DCC subclass member 3. (809 aa)
C1QBPComplement C1q binding protein. (281 aa)
UNC5BUnc-5 netrin receptor B. (904 aa)
ENSCATP00000037470AAA domain-containing protein. (389 aa)
PSMB6Proteasome subunit beta. (285 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
ENSCATP0000003771414_3_3 domain-containing protein; Belongs to the 14-3-3 family. (232 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (831 aa)
PSMA4Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (307 aa)
DAPK3Death associated protein kinase 3. (422 aa)
PSMB9Proteasome subunit beta. (219 aa)
IGDCC4Immunoglobulin superfamily DCC subclass member 4. (1250 aa)
ENSCATP00000038453Uncharacterized protein; Belongs to the peptidase C14A family. (262 aa)
NPVFNeuropeptide VF precursor. (196 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (379 aa)
LOC105587074Uncharacterized protein. (186 aa)
DFFADNA fragmentation factor subunit alpha. (331 aa)
TFDP1Transcription factor. (417 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (315 aa)
MLKLMixed lineage kinase domain like pseudokinase. (477 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
ENSCATP00000040310ANK_REP_REGION domain-containing protein. (159 aa)
FASTumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). (331 aa)
ENSCATP0000004057614_3_3 domain-containing protein; Belongs to the 14-3-3 family. (196 aa)
APC2APC regulator of WNT signaling pathway 2. (2301 aa)
MAP2Microtubule-associated protein. (1914 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
LOC105571593Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
BCAP31B cell receptor associated protein 31. (313 aa)
ENSCATP00000041490AAA domain-containing protein; Belongs to the AAA ATPase family. (199 aa)
ENSCATP00000041581Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
ENSCATP00000042056Dynein light chain. (74 aa)
PSME3Proteasome activator subunit 3. (265 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
DAPK2Death associated protein kinase 2; Belongs to the protein kinase superfamily. (488 aa)
PPP1R13BProtein phosphatase 1 regulatory subunit 13B. (1090 aa)
CHMP2BCharged multivesicular body protein 2B. (213 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
CHMP4CCharged multivesicular body protein 4C. (233 aa)
ENSCATP00000042857Dynein light chain. (79 aa)
ENSCATP00000042870Uncharacterized protein. (348 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
CLSPNClaspin. (1342 aa)
PSMB5Proteasome subunit beta. (263 aa)
CHMP4BCharged multivesicular body protein 4B. (224 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (508 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
CARD18Caspase recruitment domain family member 18. (92 aa)
ENSCATP00000043644Ubiquitin-like domain-containing protein. (120 aa)
BMXTyrosine-protein kinase. (679 aa)
ACIN1Apoptotic chromatin condensation inducer 1. (1340 aa)
BNIP5BCL2 interacting protein 5. (651 aa)
STK25Serine/threonine kinase 25. (426 aa)
DYNLL1Dynein light chain. (89 aa)
PSME2Proteasome activator subunit 2. (239 aa)
PSME4Proteasome activator subunit 4. (1792 aa)
DSG2Desmoglein 2. (1118 aa)
ENSCATP00000045432Uncharacterized protein. (173 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (281 aa)
TP53BP2Tumor protein p53 binding protein 2. (1134 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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