37 items (Cercocebus atys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	LOC105585293	Uncharacterized protein. (290 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
	ERAS	ES cell expressed Ras. (233 aa)
	FLRT2	Fibronectin leucine rich transmembrane protein 2. (660 aa)
	ENSCATP00000005869	Uncharacterized protein. (526 aa)
	GAB1	GRB2 associated binding protein 1. (724 aa)
	FLRT3	Fibronectin leucine rich transmembrane protein 3. (649 aa)
	ENSCATP00000007407	PID domain-containing protein. (502 aa)
	FGF3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	PTPN11	Protein tyrosine phosphatase non-receptor type 11. (552 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	FGF5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
	FGF17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	KL	Klotho. (1001 aa)
	ENSCATP00000044421	Uncharacterized protein. (441 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	FGFR1	Fibroblast growth factor receptor. (820 aa)
	FGF22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	FRS3	Fibroblast growth factor receptor substrate 3. (492 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	FLRT1	Fibronectin leucine rich transmembrane protein 1. (674 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (522 aa)
	CSDE1	Cold shock domain containing E1. (844 aa)
	SHC1	SHC adaptor protein 1. (584 aa)

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	FGF4	ENSCATP00000027187	ENSCATP00000021933	Cold shock domain containing E1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.407
CSDE1	FGFR1	ENSCATP00000027187	ENSCATP00000041327	Cold shock domain containing E1.	Fibroblast growth factor receptor.	0.417
CSDE1	GRB2	ENSCATP00000027187	ENSCATP00000042750	Cold shock domain containing E1.	Growth factor receptor bound protein 2.	0.605
CSDE1	NRAS	ENSCATP00000027187	ENSCATP00000036364	Cold shock domain containing E1.	NRAS proto-oncogene, GTPase.	0.409
CSDE1	PIK3CA	ENSCATP00000027187	ENSCATP00000027089	Cold shock domain containing E1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.834
CSDE1	PIK3R1	ENSCATP00000027187	ENSCATP00000027907	Cold shock domain containing E1.	Phosphoinositide-3-kinase regulatory subunit 1.	0.574
CSDE1	SOS1	ENSCATP00000027187	ENSCATP00000004020	Cold shock domain containing E1.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.723
ENSCATP00000005869	ENSCATP00000007407	ENSCATP00000005869	ENSCATP00000007407	Uncharacterized protein.	PID domain-containing protein.	0.567
ENSCATP00000005869	ERAS	ENSCATP00000005869	ENSCATP00000004476	Uncharacterized protein.	ES cell expressed Ras.	0.417
ENSCATP00000005869	FGF1	ENSCATP00000005869	ENSCATP00000016793	Uncharacterized protein.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.412
ENSCATP00000005869	FGF3	ENSCATP00000005869	ENSCATP00000007994	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.445
ENSCATP00000005869	FGF4	ENSCATP00000005869	ENSCATP00000021933	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.445
ENSCATP00000005869	FGF5	ENSCATP00000005869	ENSCATP00000045960	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.442
ENSCATP00000005869	FGF8	ENSCATP00000005869	ENSCATP00000016325	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.423
ENSCATP00000005869	FGFR1	ENSCATP00000005869	ENSCATP00000041327	Uncharacterized protein.	Fibroblast growth factor receptor.	0.462
ENSCATP00000005869	FRS2	ENSCATP00000005869	ENSCATP00000027898	Uncharacterized protein.	Fibroblast growth factor receptor substrate 2.	0.891
ENSCATP00000005869	FRS3	ENSCATP00000005869	ENSCATP00000032560	Uncharacterized protein.	Fibroblast growth factor receptor substrate 3.	0.728
ENSCATP00000005869	GAB1	ENSCATP00000005869	ENSCATP00000005920	Uncharacterized protein.	GRB2 associated binding protein 1.	0.932
ENSCATP00000005869	GRB2	ENSCATP00000005869	ENSCATP00000042750	Uncharacterized protein.	Growth factor receptor bound protein 2.	0.943
ENSCATP00000005869	HRAS	ENSCATP00000005869	ENSCATP00000014290	Uncharacterized protein.	HRas proto-oncogene, GTPase.	0.485