STRINGSTRING
SOS1 SOS1 FGF2 FGF2 FGF20 FGF20 ERAS ERAS ENSCATP00000007407 ENSCATP00000007407 FGF3 FGF3 FGF9 FGF9 KRAS KRAS HRAS HRAS FGF8 FGF8 FGF1 FGF1 FGF4 FGF4 LOC105585293 LOC105585293 FGF6 FGF6 SHC1 SHC1 CSDE1 CSDE1 FGF10 FGF10 FGF23 FGF23 NRAS NRAS FGF22 FGF22 FGFR1 FGFR1 GRB2 GRB2 KL KL FGF17 FGF17 FGF5 FGF5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
ERASES cell expressed Ras. (233 aa)
ENSCATP00000007407PID domain-containing protein. (502 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
LOC105585293Uncharacterized protein. (290 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
SHC1SHC adaptor protein 1. (584 aa)
CSDE1Cold shock domain containing E1. (844 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
KLKlotho. (1001 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.