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RAD51C | RAD51 paralog C. (367 aa) | ||||
EME1 | Essential meiotic structure-specific endonuclease 1. (584 aa) | ||||
GEN1 | GEN1 Holliday junction 5' flap endonuclease. (910 aa) | ||||
RAD51AP1 | RAD51 associated protein 1. (352 aa) | ||||
RBBP8 | RB binding protein 8, endonuclease. (905 aa) | ||||
EXO1 | Exonuclease 1. (846 aa) | ||||
HUS1B | Checkpoint protein; Belongs to the HUS1 family. (277 aa) | ||||
POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2286 aa) | ||||
RFC3 | Replication factor C subunit 3. (356 aa) | ||||
RFC5 | Replication factor C subunit 5. (343 aa) | ||||
MEIOB | Meiosis specific with OB-fold. (471 aa) | ||||
POLK | DNA polymerase kappa. (845 aa) | ||||
RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1352 aa) | ||||
SPIDR | Scaffold protein involved in DNA repair. (924 aa) | ||||
RFC1 | Replication factor C subunit 1. (1113 aa) | ||||
RMI2 | RecQ mediated genome instability 2. (147 aa) | ||||
LOC105576738 | Ubiquitin-like domain-containing protein. (134 aa) | ||||
RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (390 aa) | ||||
CHEK1 | Checkpoint kinase 1. (493 aa) | ||||
LOC105579396 | Ubiquitin-like domain-containing protein. (156 aa) | ||||
LOC105595668 | Ubiquitin-like domain-containing protein. (126 aa) | ||||
RPA3 | Replication protein A3. (121 aa) | ||||
TDRD3 | Tudor domain containing 3. (744 aa) | ||||
POLD1 | DNA polymerase. (1107 aa) | ||||
RFC4 | Replication factor C subunit 4. (349 aa) | ||||
ENSCATP00000011808 | Ubiquitin-like domain-containing protein. (130 aa) | ||||
RFC2 | Replication factor C subunit 2. (352 aa) | ||||
EXD2 | Exonuclease 3'-5' domain containing 2. (620 aa) | ||||
RECQL4 | RecQ like helicase 4. (1208 aa) | ||||
PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) | ||||
BRCA2 | BRCA2 DNA repair associated. (3419 aa) | ||||
RAD51B | RAD51 paralog B. (425 aa) | ||||
UBA52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa) | ||||
NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa) | ||||
POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) | ||||
POLE4 | DNA polymerase epsilon 4, accessory subunit. (117 aa) | ||||
RCBTB2 | RCC1 and BTB domain containing protein 2. (556 aa) | ||||
RAD51 | RAD51 recombinase; Belongs to the RecA family. (309 aa) | ||||
DNA2 | DNA replication helicase/nuclease 2. (1056 aa) | ||||
RAD51D | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (346 aa) | ||||
ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2573 aa) | ||||
EME2 | Essential meiotic structure-specific endonuclease subunit 2. (379 aa) | ||||
HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) | ||||
ATRIP | ATR interacting protein. (711 aa) | ||||
POLD4 | Uncharacterized protein. (107 aa) | ||||
MUS81 | MUS81 structure-specific endonuclease subunit. (559 aa) | ||||
KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (537 aa) | ||||
ENSCATP00000031033 | Ubiquitin-like domain-containing protein. (149 aa) | ||||
RAD17 | RAD17 checkpoint clamp loader component. (643 aa) | ||||
ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3073 aa) | ||||
ENSCATP00000034029 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (581 aa) | ||||
ENSCATP00000034768 | Ubiquitin-like domain-containing protein. (144 aa) | ||||
ENSCATP00000035134 | Ubiquitin-like domain-containing protein. (146 aa) | ||||
WRN | WRN RecQ like helicase. (1418 aa) | ||||
BLM | BLM RecQ like helicase. (1416 aa) | ||||
POLD2 | DNA polymerase delta 2, accessory subunit. (504 aa) | ||||
SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (304 aa) | ||||
LOC105599742 | Zinc-hook domain-containing protein. (1192 aa) | ||||
MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa) | ||||
ENSCATP00000036401 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (262 aa) | ||||
POLH | DNA polymerase eta. (712 aa) | ||||
BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1217 aa) | ||||
PALB2 | Partner and localizer of BRCA2. (1192 aa) | ||||
RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) | ||||
RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (417 aa) | ||||
RAD1 | RAD1 checkpoint DNA exonuclease. (280 aa) | ||||
BARD1 | BRCA1 associated RING domain 1. (777 aa) | ||||
XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (381 aa) | ||||
POLD3 | Uncharacterized protein. (466 aa) | ||||
POLE3 | DNA polymerase epsilon 3, accessory subunit. (147 aa) | ||||
RPS27A | Ubiquitin-like domain-containing protein. (156 aa) | ||||
RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (240 aa) | ||||
XRCC2 | X-ray repair cross complementing 2. (280 aa) | ||||
ENSCATP00000043644 | Ubiquitin-like domain-containing protein. (120 aa) | ||||
SLX4 | SLX4 structure-specific endonuclease subunit. (1813 aa) | ||||
TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (994 aa) | ||||
BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1871 aa) | ||||
TOPBP1 | DNA topoisomerase II binding protein 1. (1527 aa) |