STRINGSTRING
RAD51C RAD51C EME1 EME1 GEN1 GEN1 RAD51AP1 RAD51AP1 RBBP8 RBBP8 EXO1 EXO1 HUS1B HUS1B POLE POLE RFC3 RFC3 RFC5 RFC5 MEIOB MEIOB POLK POLK RTEL1 RTEL1 SPIDR SPIDR RFC1 RFC1 RMI2 RMI2 LOC105576738 LOC105576738 RAD9A RAD9A CHEK1 CHEK1 LOC105579396 LOC105579396 LOC105595668 LOC105595668 RPA3 RPA3 TDRD3 TDRD3 POLD1 POLD1 RFC4 RFC4 ENSCATP00000011808 ENSCATP00000011808 RFC2 RFC2 EXD2 EXD2 RECQL4 RECQL4 PCNA PCNA BRCA2 BRCA2 RAD51B RAD51B UBA52 UBA52 NBN NBN POLE2 POLE2 POLE4 POLE4 RCBTB2 RCBTB2 RAD51 RAD51 DNA2 DNA2 RAD51D RAD51D ATR ATR EME2 EME2 HUS1 HUS1 ATRIP ATRIP POLD4 POLD4 MUS81 MUS81 KAT5 KAT5 ENSCATP00000031033 ENSCATP00000031033 RAD17 RAD17 ATM ATM ENSCATP00000034029 ENSCATP00000034029 ENSCATP00000034768 ENSCATP00000034768 ENSCATP00000035134 ENSCATP00000035134 WRN WRN BLM BLM POLD2 POLD2 SLX1A SLX1A LOC105599742 LOC105599742 MRE11 MRE11 ENSCATP00000036401 ENSCATP00000036401 POLH POLH BRIP1 BRIP1 PALB2 PALB2 RCBTB1 RCBTB1 RAD9B RAD9B RAD1 RAD1 BARD1 BARD1 XRCC3 XRCC3 POLD3 POLD3 POLE3 POLE3 RPS27A RPS27A RHNO1 RHNO1 XRCC2 XRCC2 ENSCATP00000043644 ENSCATP00000043644 SLX4 SLX4 TOP3A TOP3A BRCA1 BRCA1 TOPBP1 TOPBP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAD51CRAD51 paralog C. (367 aa)
EME1Essential meiotic structure-specific endonuclease 1. (584 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (910 aa)
RAD51AP1RAD51 associated protein 1. (352 aa)
RBBP8RB binding protein 8, endonuclease. (905 aa)
EXO1Exonuclease 1. (846 aa)
HUS1BCheckpoint protein; Belongs to the HUS1 family. (277 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2286 aa)
RFC3Replication factor C subunit 3. (356 aa)
RFC5Replication factor C subunit 5. (343 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
POLKDNA polymerase kappa. (845 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1352 aa)
SPIDRScaffold protein involved in DNA repair. (924 aa)
RFC1Replication factor C subunit 1. (1113 aa)
RMI2RecQ mediated genome instability 2. (147 aa)
LOC105576738Ubiquitin-like domain-containing protein. (134 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (390 aa)
CHEK1Checkpoint kinase 1. (493 aa)
LOC105579396Ubiquitin-like domain-containing protein. (156 aa)
LOC105595668Ubiquitin-like domain-containing protein. (126 aa)
RPA3Replication protein A3. (121 aa)
TDRD3Tudor domain containing 3. (744 aa)
POLD1DNA polymerase. (1107 aa)
RFC4Replication factor C subunit 4. (349 aa)
ENSCATP00000011808Ubiquitin-like domain-containing protein. (130 aa)
RFC2Replication factor C subunit 2. (352 aa)
EXD2Exonuclease 3'-5' domain containing 2. (620 aa)
RECQL4RecQ like helicase 4. (1208 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
BRCA2BRCA2 DNA repair associated. (3419 aa)
RAD51BRAD51 paralog B. (425 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (117 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (556 aa)
RAD51RAD51 recombinase; Belongs to the RecA family. (309 aa)
DNA2DNA replication helicase/nuclease 2. (1056 aa)
RAD51DDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (346 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2573 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (379 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
ATRIPATR interacting protein. (711 aa)
POLD4Uncharacterized protein. (107 aa)
MUS81MUS81 structure-specific endonuclease subunit. (559 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (537 aa)
ENSCATP00000031033Ubiquitin-like domain-containing protein. (149 aa)
RAD17RAD17 checkpoint clamp loader component. (643 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3073 aa)
ENSCATP00000034029Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (581 aa)
ENSCATP00000034768Ubiquitin-like domain-containing protein. (144 aa)
ENSCATP00000035134Ubiquitin-like domain-containing protein. (146 aa)
WRNWRN RecQ like helicase. (1418 aa)
BLMBLM RecQ like helicase. (1416 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (304 aa)
LOC105599742Zinc-hook domain-containing protein. (1192 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
ENSCATP00000036401Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (262 aa)
POLHDNA polymerase eta. (712 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1217 aa)
PALB2Partner and localizer of BRCA2. (1192 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (417 aa)
RAD1RAD1 checkpoint DNA exonuclease. (280 aa)
BARD1BRCA1 associated RING domain 1. (777 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (381 aa)
POLD3Uncharacterized protein. (466 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (240 aa)
XRCC2X-ray repair cross complementing 2. (280 aa)
ENSCATP00000043644Ubiquitin-like domain-containing protein. (120 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1813 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (994 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1871 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1527 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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