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| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (486 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (584 aa) |
| | ENSCATP00000000260 | FHA domain-containing protein. (142 aa) |
| | ENSCATP00000000450 | Uncharacterized protein. (276 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (910 aa) |
| | H2BC1 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | H2BC9 | Histone H2B; Belongs to the histone H2B family. (149 aa) |
| | LOC105572638 | Histone domain-containing protein; Belongs to the histone H2B family. (127 aa) |
| | LOC105572658 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (352 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (905 aa) |
| | LOC105572655 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | EXO1 | Exonuclease 1. (846 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | PARP2 | Poly [ADP-ribose] polymerase. (581 aa) |
| | H2BW1 | H2B histone family member W, testis specific; Belongs to the histone H2B family. (175 aa) |
| | HUS1B | Checkpoint protein; Belongs to the HUS1 family. (277 aa) |
| | LOC105572666 | Histone H4. (103 aa) |
| | H2BC5 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2286 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (384 aa) |
| | LOC105572652 | Histone H4. (103 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | LOC105572651 | Histone H4. (103 aa) |
| | H2BC3 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC105572676 | Histone H4. (103 aa) |
| | RFC5 | Replication factor C subunit 5. (343 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1365 aa) |
| | H2BC8 | Histone H2B type 1. (126 aa) |
| | MEIOB | Meiosis specific with OB-fold. (471 aa) |
| | LOC105572671 | Histone H4. (103 aa) |
| | POLK | DNA polymerase kappa. (845 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1352 aa) |
| | POLQ | DNA polymerase theta. (2703 aa) |
| | LOC105585120 | Histone H4. (103 aa) |
| | SPIDR | Scaffold protein involved in DNA repair. (924 aa) |
| | LOC105593194 | Histone H4. (103 aa) |
| | H3-4 | Histone cluster 3 H3. (136 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (323 aa) |
| | LOC105572665 | Histone H4. (103 aa) |
| | RFC1 | Replication factor C subunit 1. (1113 aa) |
| | H2BC7 | Histone H2B type 1. (126 aa) |
| | UBE2NL | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa) |
| | LOC105597697 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC105593174 | Histone H4. (103 aa) |
| | SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (1070 aa) |
| | H4C11 | Histone H4. (103 aa) |
| | LOC105593167 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC11 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSCATP00000005896 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (292 aa) |
| | ENSCATP00000005937 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa) |
| | LOC105573053 | IBB domain-containing protein. (407 aa) |
| | RMI2 | RecQ mediated genome instability 2. (147 aa) |
| | LOC105576738 | Ubiquitin-like domain-containing protein. (134 aa) |
| | ENSCATP00000006241 | Uncharacterized protein. (269 aa) |
| | POLM | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (494 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (390 aa) |
| | CHEK1 | Checkpoint kinase 1. (493 aa) |
| | ENSCATP00000006726 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa) |
| | H2BC21 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | LOC105593172 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC105579396 | Ubiquitin-like domain-containing protein. (156 aa) |
| | BRCC3 | MPN domain-containing protein. (293 aa) |
| | LOC105595668 | Ubiquitin-like domain-containing protein. (126 aa) |
| | TDP2 | Tyrosyl-DNA phosphodiesterase 2. (388 aa) |
| | ENSCATP00000007798 | Uncharacterized protein. (258 aa) |
| | LOC105593181 | Histone H2B type 1-M. (126 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (539 aa) |
| | H2BC13 | Histone H2B; Belongs to the histone H2B family. (136 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | EYA3 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa) |
| | ENSCATP00000009428 | Rad60-SLD domain-containing protein. (91 aa) |
| | ENSCATP00000009666 | Uncharacterized protein. (121 aa) |
| | TDRD3 | Tudor domain containing 3. (744 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | ENSCATP00000010735 | Ubiquitin-like domain-containing protein. (132 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa) |
| | POLD1 | DNA polymerase. (1107 aa) |
| | RFC4 | Replication factor C subunit 4. (349 aa) |
| | ENSCATP00000011808 | Ubiquitin-like domain-containing protein. (130 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | APBB1 | Amyloid beta precursor protein binding family B member 1. (738 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (620 aa) |
| | PAXIP1 | PAX interacting protein 1. (1079 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa) |
| | RECQL4 | RecQ like helicase 4. (1208 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | LOC105583935 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (87 aa) |
| | ENSCATP00000013712 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (140 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (415 aa) |
| | H2BC15 | Histone H2B; Belongs to the histone H2B family. (166 aa) |
| | NHEJ1 | Non-homologous end joining factor 1. (299 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (334 aa) |
| | PPP5C | Serine/threonine-protein phosphatase. (501 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3419 aa) |
| | ENSCATP00000015553 | Histone H2B; Belongs to the histone H2B family. (129 aa) |
| | RAD51B | RAD51 paralog B. (425 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (329 aa) |
| | KPNA2 | Importin subunit alpha; Functions in nuclear protein import. (469 aa) |
| | UBA52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa) |
| | SLC23A3 | Solute carrier family 23 member 3. (610 aa) |
| | ABL1 | Tyrosine-protein kinase. (1149 aa) |
| | PWWP2A | PWWP domain containing 2A. (755 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1979 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | ENSCATP00000018692 | MPN domain-containing protein. (273 aa) |
| | RIF1 | Replication timing regulatory factor 1. (2466 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (117 aa) |
| | RCBTB2 | RCC1 and BTB domain containing protein 2. (556 aa) |
| | RAD51 | RAD51 recombinase; Belongs to the RecA family. (309 aa) |
| | LOC105587115 | Ku domain-containing protein. (501 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1056 aa) |
| | RAD51D | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (346 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2573 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (379 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | ENSCATP00000022492 | Uncharacterized protein. (65 aa) |
| | ENSCATP00000022567 | Rad60-SLD domain-containing protein. (78 aa) |
| | TMEM182 | Transmembrane protein 182. (229 aa) |
| | ATRIP | ATR interacting protein. (711 aa) |
| | ENSCATP00000022935 | IBB domain-containing protein. (73 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa) |
| | CHEK2 | Checkpoint kinase 2. (589 aa) |
| | APBB2 | Amyloid beta precursor protein binding family B member 2. (759 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (412 aa) |
| | POLD4 | Uncharacterized protein. (107 aa) |
| | SUMO1 | Ubiquitin-like domain-containing protein. (146 aa) |
| | LOC105593170 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (101 aa) |
| | TIMELESS | Timeless circadian regulator. (1208 aa) |
| | ENSCATP00000024775 | Uncharacterized protein. (90 aa) |
| | RNF4 | Ring finger protein 4. (190 aa) |
| | ENSCATP00000025399 | Histone H2B; Belongs to the histone H2B family. (134 aa) |
| | CNPPD1 | Cyclin Pas1/PHO80 domain containing 1. (410 aa) |
| | BAP1 | Ubiquitin carboxyl-terminal hydrolase. (736 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (561 aa) |
| | UBXN1 | UBX domain protein 1. (297 aa) |
| | TDP1 | Tyrosyl-DNA phosphodiesterase 1. (603 aa) |
| | ENSCATP00000027939 | Uncharacterized protein. (240 aa) |
| | ENSCATP00000029205 | Rad60-SLD domain-containing protein. (74 aa) |
| | UBE2I | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (237 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (559 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (537 aa) |
| | ENSCATP00000030652 | Ubiquitin-like domain-containing protein. (136 aa) |
| | EYA2 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (538 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (515 aa) |
| | ENSCATP00000031033 | Ubiquitin-like domain-containing protein. (149 aa) |
| | ENSCATP00000031206 | Ubiquitin-like domain-containing protein. (128 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (643 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (465 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3073 aa) |
| | SIRT6 | Sirtuin 6. (355 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (643 aa) |
| | ENSCATP00000032866 | Uncharacterized protein. (66 aa) |
| | BAZ1B | Bromodomain adjacent to zinc finger domain 1B. (1469 aa) |
| | ENSCATP00000033184 | Importin subunit alpha; Functions in nuclear protein import. (467 aa) |
| | ENSCATP00000034029 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (581 aa) |
| | RAD51C | RAD51 paralog C. (367 aa) |
| | ENSCATP00000034768 | Ubiquitin-like domain-containing protein. (144 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (307 aa) |
| | ENSCATP00000035134 | Ubiquitin-like domain-containing protein. (146 aa) |
| | WRN | WRN RecQ like helicase. (1418 aa) |
| | BLM | BLM RecQ like helicase. (1416 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (504 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (684 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (304 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (397 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa) |
| | LOC105599742 | Zinc-hook domain-containing protein. (1192 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa) |
| | ENSCATP00000036401 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (262 aa) |
| | DCLRE1C | DNA cross-link repair 1C. (653 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (799 aa) |
| | KDM4B | Lysine demethylase 4B. (1198 aa) |
| | HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4801 aa) |
| | POLH | DNA polymerase eta. (712 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1217 aa) |
| | SIRT7 | Sirtuin 7. (400 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1192 aa) |
| | ENSCATP00000039008 | Uncharacterized protein. (112 aa) |
| | XRCC6 | X-ray repair cross complementing 6. (609 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | LOC105597804 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (132 aa) |
| | DNTT | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (510 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (417 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (280 aa) |
| | LOC105598099 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (777 aa) |
| | RNF169 | Ring finger protein 169. (708 aa) |
| | EYA4 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (639 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (381 aa) |
| | H2BU1 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | POLD3 | Uncharacterized protein. (466 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (147 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (156 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (474 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (240 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (307 aa) |
| | PPP4R2 | Uncharacterized protein. (417 aa) |
| | CLSPN | Claspin. (1342 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (280 aa) |
| | ENSCATP00000043644 | Ubiquitin-like domain-containing protein. (120 aa) |
| | UBE2N | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1813 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (994 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1871 aa) |
| | LIG3 | DNA ligase. (1009 aa) |
| | KDM4A | Uncharacterized protein. (1063 aa) |
| | SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1059 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1527 aa) |
