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| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (994 aa) |
| | ENSCATP00000000450 | Uncharacterized protein. (276 aa) |
| | H2BC1 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | H2BC9 | Histone H2B; Belongs to the histone H2B family. (149 aa) |
| | LOC105572638 | Histone domain-containing protein; Belongs to the histone H2B family. (127 aa) |
| | LOC105572658 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (905 aa) |
| | LOC105572655 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | EXO1 | Exonuclease 1. (846 aa) |
| | H2BW1 | H2B histone family member W, testis specific; Belongs to the histone H2B family. (175 aa) |
| | HUS1B | Checkpoint protein; Belongs to the HUS1 family. (277 aa) |
| | LOC105572666 | Histone H4. (103 aa) |
| | H2BC5 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC105572652 | Histone H4. (103 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | LOC105572651 | Histone H4. (103 aa) |
| | H2BC3 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC105572676 | Histone H4. (103 aa) |
| | RFC5 | Replication factor C subunit 5. (343 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1365 aa) |
| | H2BC8 | Histone H2B type 1. (126 aa) |
| | LOC105572671 | Histone H4. (103 aa) |
| | LOC105585120 | Histone H4. (103 aa) |
| | LOC105593194 | Histone H4. (103 aa) |
| | H3-4 | Histone cluster 3 H3. (136 aa) |
| | LOC105572665 | Histone H4. (103 aa) |
| | H2BC7 | Histone H2B type 1. (126 aa) |
| | UBE2NL | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa) |
| | LOC105597697 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC105593174 | Histone H4. (103 aa) |
| | H4C11 | Histone H4. (103 aa) |
| | LOC105593167 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC11 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSCATP00000005896 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (292 aa) |
| | ENSCATP00000005937 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa) |
| | RMI2 | RecQ mediated genome instability 2. (147 aa) |
| | ENSCATP00000006241 | Uncharacterized protein. (269 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (390 aa) |
| | CHEK1 | Checkpoint kinase 1. (493 aa) |
| | ENSCATP00000006726 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa) |
| | H2BC21 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC105593172 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC105579396 | Ubiquitin-like domain-containing protein. (156 aa) |
| | BRCC3 | MPN domain-containing protein. (293 aa) |
| | ENSCATP00000007798 | Uncharacterized protein. (258 aa) |
| | LOC105593181 | Histone H2B type 1-M. (126 aa) |
| | H2BC13 | Histone H2B; Belongs to the histone H2B family. (136 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | ENSCATP00000010735 | Ubiquitin-like domain-containing protein. (132 aa) |
| | RFC4 | Replication factor C subunit 4. (349 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | RECQL4 | RecQ like helicase 4. (1208 aa) |
| | LOC105583935 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (87 aa) |
| | ENSCATP00000013712 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (140 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (415 aa) |
| | H2BC15 | Histone H2B; Belongs to the histone H2B family. (166 aa) |
| | ENSCATP00000015553 | Histone H2B; Belongs to the histone H2B family. (129 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (329 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1979 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa) |
| | ENSCATP00000018692 | MPN domain-containing protein. (273 aa) |
| | RCBTB2 | RCC1 and BTB domain containing protein 2. (556 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1056 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2573 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | ENSCATP00000022492 | Uncharacterized protein. (65 aa) |
| | ATRIP | ATR interacting protein. (711 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (412 aa) |
| | LOC105593170 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (101 aa) |
| | TIMELESS | Timeless circadian regulator. (1208 aa) |
| | RNF4 | Ring finger protein 4. (190 aa) |
| | ENSCATP00000025399 | Histone H2B; Belongs to the histone H2B family. (134 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (561 aa) |
| | ENSCATP00000029205 | Rad60-SLD domain-containing protein. (74 aa) |
| | UBE2I | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (237 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (537 aa) |
| | ENSCATP00000030652 | Ubiquitin-like domain-containing protein. (136 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (515 aa) |
| | ENSCATP00000031033 | Ubiquitin-like domain-containing protein. (149 aa) |
| | ENSCATP00000031206 | Ubiquitin-like domain-containing protein. (128 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (643 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (465 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3073 aa) |
| | SIRT6 | Sirtuin 6. (355 aa) |
| | ENSCATP00000032866 | Uncharacterized protein. (66 aa) |
| | ENSCATP00000034029 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (581 aa) |
| | ENSCATP00000034768 | Ubiquitin-like domain-containing protein. (144 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (307 aa) |
| | ENSCATP00000035134 | Ubiquitin-like domain-containing protein. (146 aa) |
| | WRN | WRN RecQ like helicase. (1418 aa) |
| | BLM | BLM RecQ like helicase. (1416 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (684 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa) |
| | LOC105599742 | Zinc-hook domain-containing protein. (1192 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa) |
| | ENSCATP00000036401 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (262 aa) |
| | HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4801 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1217 aa) |
| | ENSCATP00000039008 | Uncharacterized protein. (112 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | LOC105597804 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (132 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (417 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (280 aa) |
| | LOC105598099 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (777 aa) |
| | RNF169 | Ring finger protein 169. (708 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (486 aa) |
| | H2BU1 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (156 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (240 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (307 aa) |
| | PPP4R2 | Uncharacterized protein. (417 aa) |
| | CLSPN | Claspin. (1342 aa) |
| | UBE2N | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1871 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1527 aa) |
| | UBA52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa) |
