STRINGSTRING
PROSER1 PROSER1 ERCC4 ERCC4 ATR ATR FANCE FANCE EME2 EME2 FANCB FANCB ATRIP ATRIP DCLRE1A DCLRE1A CENPX CENPX FAAP24 FAAP24 FANCI FANCI ENSCATP00000029234 ENSCATP00000029234 POLN POLN MUS81 MUS81 FANCD2 FANCD2 ENSCATP00000031033 ENSCATP00000031033 WDR48 WDR48 SLX4 SLX4 ENSCATP00000043644 ENSCATP00000043644 RPS27A RPS27A ENSCATP00000041476 ENSCATP00000041476 ENSCATP00000036401 ENSCATP00000036401 SLX1A SLX1A ENSCATP00000035134 ENSCATP00000035134 ENSCATP00000034768 ENSCATP00000034768 FAAP20 FAAP20 FANCL FANCL UBE2T UBE2T EME1 EME1 ENSCATP00000000544 ENSCATP00000000544 MEIOB MEIOB USP1 USP1 DCLRE1B DCLRE1B ERCC1 ERCC1 LOC105576738 LOC105576738 LOC105579396 LOC105579396 LOC105595668 LOC105595668 FAAP100 FAAP100 NUTF2 NUTF2 RPA3 RPA3 FANCA FANCA FANCG FANCG ENSCATP00000011808 ENSCATP00000011808 FANCC FANCC ENSCATP00000014233 ENSCATP00000014233 FANCM FANCM UBA52 UBA52 FAN1 FAN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PROSER1Proline and serine rich 1. (936 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2573 aa)
FANCEFA complementation group E. (536 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (379 aa)
FANCBFA complementation group B. (858 aa)
ATRIPATR interacting protein. (711 aa)
DCLRE1ADNA cross-link repair 1A. (1040 aa)
CENPXCentromere protein X. (133 aa)
FAAP24FA core complex associated protein 24. (215 aa)
FANCIFA complementation group I. (1328 aa)
ENSCATP00000029234NTF2 domain-containing protein. (113 aa)
POLNDNA polymerase nu. (869 aa)
MUS81MUS81 structure-specific endonuclease subunit. (559 aa)
FANCD2Uncharacterized protein. (1382 aa)
ENSCATP00000031033Ubiquitin-like domain-containing protein. (149 aa)
WDR48WD repeat domain 48. (679 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1813 aa)
ENSCATP00000043644Ubiquitin-like domain-containing protein. (120 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
ENSCATP00000041476NTF2 domain-containing protein. (119 aa)
ENSCATP00000036401Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (262 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (304 aa)
ENSCATP00000035134Ubiquitin-like domain-containing protein. (146 aa)
ENSCATP00000034768Ubiquitin-like domain-containing protein. (144 aa)
FAAP20Uncharacterized protein. (184 aa)
FANCLFA complementation group L. (380 aa)
UBE2TUbiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (197 aa)
EME1Essential meiotic structure-specific endonuclease 1. (584 aa)
ENSCATP00000000544NTF2 domain-containing protein. (120 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
USP1Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (785 aa)
DCLRE1BDNA cross-link repair 1B. (532 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (323 aa)
LOC105576738Ubiquitin-like domain-containing protein. (134 aa)
LOC105579396Ubiquitin-like domain-containing protein. (156 aa)
LOC105595668Ubiquitin-like domain-containing protein. (126 aa)
FAAP100FA core complex associated protein 100. (881 aa)
NUTF2NTF2 domain-containing protein. (127 aa)
RPA3Replication protein A3. (121 aa)
FANCAFA complementation group A. (1430 aa)
FANCGFA complementation group G. (622 aa)
ENSCATP00000011808Ubiquitin-like domain-containing protein. (130 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (558 aa)
ENSCATP00000014233Uncharacterized protein. (276 aa)
FANCMFA complementation group M. (2050 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1016 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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