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ENSCATP00000003394 ENSCATP00000003394 ENSCATP00000003644 ENSCATP00000003644 MEIOB MEIOB PSMA1 PSMA1 CDKN1A CDKN1A PSMF1 PSMF1 ENSCATP00000004934 ENSCATP00000004934 POLA2 POLA2 CDK4 CDK4 ORC2 ORC2 E2F6 E2F6 RB1 RB1 LOC105576738 LOC105576738 ENSCATP00000006421 ENSCATP00000006421 AKT1 AKT1 PSMC3 PSMC3 LOC105579396 LOC105579396 LOC105595668 LOC105595668 PSMD7 PSMD7 PSMB8 PSMB8 PPP2R1B PPP2R1B RPA3 RPA3 DBF4 DBF4 ENSCATP00000010330 ENSCATP00000010330 MCM6 MCM6 CCNA2 CCNA2 MCM2 MCM2 PSMA2 PSMA2 ENSCATP00000010732 ENSCATP00000010732 ENSCATP00000011080 ENSCATP00000011080 ENSCATP00000011745 ENSCATP00000011745 ENSCATP00000011808 ENSCATP00000011808 TYMS TYMS ENSCATP00000011971 ENSCATP00000011971 PSMD6 PSMD6 LIN52 LIN52 ENSCATP00000012945 ENSCATP00000012945 PCNA PCNA PSMD4 PSMD4 CDC6 CDC6 PSMC6 PSMC6 MNAT1 MNAT1 RRM2 RRM2 LIN37 LIN37 ENSCATP00000014541 ENSCATP00000014541 PRIM1 PRIM1 PPP2R3C PPP2R3C MCM4 MCM4 MCM3 MCM3 PSMB3 PSMB3 ENSCATP00000015253 ENSCATP00000015253 MAX MAX ENSCATP00000016334 ENSCATP00000016334 ORC5 ORC5 E2F5 E2F5 ENSCATP00000016481 ENSCATP00000016481 CDC7 CDC7 UBA52 UBA52 CDC45 CDC45 LOC105579883 LOC105579883 MCM10 MCM10 PSMB10 PSMB10 PSMD12 PSMD12 CDC25A CDC25A POLE2 POLE2 PSMA5 PSMA5 PSMD10 PSMD10 ENSCATP00000019356 ENSCATP00000019356 POLE4 POLE4 AKT3 AKT3 ENSCATP00000020004 ENSCATP00000020004 ENSCATP00000020093 ENSCATP00000020093 WEE1 WEE1 PSMB7 PSMB7 ENSCATP00000020357 ENSCATP00000020357 PSMC5 PSMC5 ENSCATP00000020493 ENSCATP00000020493 SKP2 SKP2 KIAA2012 KIAA2012 ENSCATP00000021172 ENSCATP00000021172 PSME1 PSME1 PSMD9 PSMD9 LOC105585327 LOC105585327 TK1 TK1 GMNN GMNN PPP4R1 PPP4R1 TFDP2 TFDP2 RELCH RELCH LIN9 LIN9 CDK7 CDK7 PSMB1 PSMB1 ENSCATP00000026110 ENSCATP00000026110 CKS2 CKS2 CCNE1 CCNE1 MCM8 MCM8 ENSCATP00000027386 ENSCATP00000027386 PPP2R3A PPP2R3A CABLES1 CABLES1 PSMD2 PSMD2 ENSCATP00000027778 ENSCATP00000027778 PSMD1 PSMD1 PSMD8 PSMD8 LOC105573488 LOC105573488 MYC MYC PSMA6 PSMA6 CDK1 CDK1 PSMC1 PSMC1 FNBP4 FNBP4 ENSCATP00000031033 ENSCATP00000031033 PPP2R3B PPP2R3B PSMB2 PSMB2 MCM7 MCM7 ENSCATP00000031804 ENSCATP00000031804 AKT2 AKT2 PTK6 PTK6 CCNA1 CCNA1 PSMB4 PSMB4 LOC105575995 LOC105575995 ENSCATP00000000117 ENSCATP00000000117 PSMA3 PSMA3 E2F1 E2F1 POLA1 POLA1 TM4SF19 TM4SF19 CDKN1B CDKN1B PPP2CA PPP2CA PSMC2 PSMC2 MCM9 MCM9 RBL1 RBL1 PPP2R1A PPP2R1A CCND1 CCND1 ENSCATP00000034742 ENSCATP00000034742 ENSCATP00000034768 ENSCATP00000034768 ENSCATP00000035052 ENSCATP00000035052 LIN54 LIN54 ENSCATP00000035134 ENSCATP00000035134 PPP4R4 PPP4R4 CDK3 CDK3 ENSCATP00000036401 ENSCATP00000036401 CUL1 CUL1 PSMD3 PSMD3 ENSCATP00000037470 ENSCATP00000037470 PSMB6 PSMB6 CCNH CCNH LOC105576107 LOC105576107 PSMA4 PSMA4 PSMB9 PSMB9 SKP1 SKP1 PSMD13 PSMD13 ORC6 ORC6 ENSCATP00000039365 ENSCATP00000039365 TFDP1 TFDP1 PSMC4 PSMC4 PSMD14 PSMD14 E2F4 E2F4 CCNB1 CCNB1 ORC1 ORC1 ENSCATP00000040310 ENSCATP00000040310 CDK2 CDK2 ORC3 ORC3 ENSCATP00000041490 ENSCATP00000041490 POLE3 POLE3 RPS27A RPS27A PSME3 PSME3 PSMD11 PSMD11 MCM5 MCM5 PSMB5 PSMB5 CDT1 CDT1 HDAC1 HDAC1 PSMD5 PSMD5 ENSCATP00000043644 ENSCATP00000043644 RBBP4 RBBP4 RPA2 RPA2 ENSCATP00000044566 ENSCATP00000044566 PSME2 PSME2 ORC4 ORC4 CCNE2 CCNE2 FBXO5 FBXO5 ENSCATP00000000278 ENSCATP00000000278 ENSCATP00000000583 ENSCATP00000000583 WEE2 WEE2 CKS1B CKS1B POLE POLE RBL2 RBL2 PPP2CB PPP2CB ENSCATP00000002953 ENSCATP00000002953 PSMA7 PSMA7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCATP00000003394Transcription factor. (393 aa)
ENSCATP00000003644ANK_REP_REGION domain-containing protein. (116 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
PSMA1Proteasome subunit alpha type. (269 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
ENSCATP00000004934ATPase_AAA_core domain-containing protein; Belongs to the AAA ATPase family. (177 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
ORC2Origin recognition complex subunit 2. (577 aa)
E2F6E2F transcription factor 6. (281 aa)
RB1RB transcriptional corepressor 1. (926 aa)
LOC105576738Ubiquitin-like domain-containing protein. (134 aa)
ENSCATP00000006421Protein kinase domain-containing protein. (297 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PSMC3AAA domain-containing protein; Belongs to the AAA ATPase family. (439 aa)
LOC105579396Ubiquitin-like domain-containing protein. (156 aa)
LOC105595668Ubiquitin-like domain-containing protein. (126 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
PSMB8Proteasome subunit beta. (276 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
RPA3Replication protein A3. (121 aa)
DBF4DBF4 zinc finger. (675 aa)
ENSCATP00000010330Uncharacterized protein. (393 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
MCM2DNA helicase; Belongs to the MCM family. (904 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
ENSCATP00000010732CSN8_PSD8_EIF3K domain-containing protein. (249 aa)
ENSCATP00000011080Uncharacterized protein. (77 aa)
ENSCATP00000011745AAA domain-containing protein. (410 aa)
ENSCATP00000011808Ubiquitin-like domain-containing protein. (130 aa)
TYMSThymidylate synthetase. (308 aa)
ENSCATP00000011971Uncharacterized protein. (191 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (442 aa)
LIN52Lin-52 DREAM MuvB core complex component. (116 aa)
ENSCATP00000012945Protein kinase domain-containing protein. (101 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (363 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (599 aa)
PSMC6AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
RRM2Uncharacterized protein. (394 aa)
LIN37Lin-37 DREAM MuvB core complex component. (296 aa)
ENSCATP00000014541Prot_ATP_ID_OB domain-containing protein. (172 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (420 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
MCM3DNA helicase; Belongs to the MCM family. (853 aa)
PSMB3Proteasome subunit beta. (205 aa)
ENSCATP00000015253AAA domain-containing protein. (373 aa)
MAXMYC associated factor X. (160 aa)
ENSCATP00000016334Uncharacterized protein. (338 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
E2F5E2F transcription factor 5. (346 aa)
ENSCATP00000016481AAA domain-containing protein. (370 aa)
CDC7Protein kinase domain-containing protein. (574 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
CDC45Cell division cycle 45. (598 aa)
LOC105579883Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (238 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (877 aa)
PSMB10Proteasome subunit beta. (273 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
CDC25ACell division cycle 25A. (524 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
ENSCATP00000019356RPA_C domain-containing protein. (276 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (117 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSCATP00000020004Uncharacterized protein; Belongs to the SKP1 family. (198 aa)
ENSCATP00000020093Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (433 aa)
WEE1Wee1-like protein kinase. (646 aa)
PSMB7Proteasome subunit beta. (277 aa)
ENSCATP00000020357AAA domain-containing protein; Belongs to the AAA ATPase family. (414 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
ENSCATP00000020493Uncharacterized protein. (150 aa)
SKP2S-phase kinase associated protein 2. (437 aa)
KIAA2012KIAA2012. (1180 aa)
ENSCATP00000021172Uncharacterized protein. (278 aa)
PSME1Proteasome activator subunit 1. (249 aa)
PSMD9PDZ domain-containing protein. (223 aa)
LOC105585327WRNPLPNID domain-containing protein. (954 aa)
TK1Thymidine kinase. (275 aa)
GMNNGeminin DNA replication inhibitor. (211 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (907 aa)
TFDP2Transcription factor. (446 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1216 aa)
LIN9Lin-9 DREAM MuvB core complex component. (558 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
PSMB1Proteasome subunit beta. (241 aa)
ENSCATP00000026110Uncharacterized protein. (222 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
MCM8MCM domain-containing protein; Belongs to the MCM family. (880 aa)
ENSCATP00000027386Uncharacterized protein. (109 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1150 aa)
CABLES1Cdk5 and Abl enzyme substrate 1. (629 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
ENSCATP00000027778WD_REPEATS_REGION domain-containing protein. (356 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (350 aa)
LOC105573488WD_REPEATS_REGION domain-containing protein. (371 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
CDK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
FNBP4Formin binding protein 4. (1017 aa)
ENSCATP00000031033Ubiquitin-like domain-containing protein. (149 aa)
PPP2R3BEF-hand domain-containing protein. (176 aa)
PSMB2Proteasome subunit beta. (201 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
ENSCATP00000031804WD_REPEATS_REGION domain-containing protein. (361 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PTK6Tyrosine-protein kinase. (507 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (274 aa)
LOC105575995WD_REPEATS_REGION domain-containing protein. (430 aa)
ENSCATP00000000117Uncharacterized protein. (93 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
E2F1E2F transcription factor 1. (437 aa)
POLA1DNA polymerase. (1469 aa)
TM4SF19Uncharacterized protein. (209 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (465 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1142 aa)
RBL1RB transcriptional corepressor like 1. (1108 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
ENSCATP00000034742JAB_MPN domain-containing protein. (166 aa)
ENSCATP00000034768Ubiquitin-like domain-containing protein. (144 aa)
ENSCATP00000035052Uncharacterized protein. (211 aa)
LIN54Lin-54 DREAM MuvB core complex component. (749 aa)
ENSCATP00000035134Ubiquitin-like domain-containing protein. (146 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (872 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
ENSCATP00000036401Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (262 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
ENSCATP00000037470AAA domain-containing protein. (389 aa)
PSMB6Proteasome subunit beta. (285 aa)
CCNHCyclin H; Belongs to the cyclin family. (325 aa)
LOC105576107Protein kinase domain-containing protein. (322 aa)
PSMA4Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (307 aa)
PSMB9Proteasome subunit beta. (219 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (165 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (379 aa)
ORC6Origin recognition complex subunit 6. (229 aa)
ENSCATP00000039365WD_REPEATS_REGION domain-containing protein. (253 aa)
TFDP1Transcription factor. (417 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (315 aa)
E2F4E2F transcription factor 4. (427 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (433 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (858 aa)
ENSCATP00000040310ANK_REP_REGION domain-containing protein. (159 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
ORC3Origin recognition complex subunit 3. (716 aa)
ENSCATP00000041490AAA domain-containing protein; Belongs to the AAA ATPase family. (199 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
PSME3Proteasome activator subunit 3. (265 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
PSMB5Proteasome subunit beta. (263 aa)
CDT1Chromatin licensing and DNA replication factor 1. (545 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (508 aa)
ENSCATP00000043644Ubiquitin-like domain-containing protein. (120 aa)
RBBP4WD_REPEATS_REGION domain-containing protein. (424 aa)
RPA2Replication protein A2. (270 aa)
ENSCATP00000044566Protein kinase domain-containing protein. (546 aa)
PSME2Proteasome activator subunit 2. (239 aa)
ORC4Origin recognition complex subunit 4. (339 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
FBXO5F-box protein 5. (448 aa)
ENSCATP00000000278Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (86 aa)
ENSCATP00000000583Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (65 aa)
WEE2Wee1-like protein kinase. (568 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2286 aa)
RBL2RB transcriptional corepressor like 2. (1139 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
ENSCATP00000002953Uncharacterized protein. (85 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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