STRINGSTRING
RPA3 RPA3 TDRD3 TDRD3 RFC4 RFC4 RFC2 RFC2 EXD2 EXD2 ENSCATP00000012820 ENSCATP00000012820 RECQL4 RECQL4 LOC105583935 LOC105583935 CDC25C CDC25C ENSCATP00000013712 ENSCATP00000013712 BABAM2 BABAM2 H2BC15 H2BC15 ENSCATP00000015553 ENSCATP00000015553 BABAM1 BABAM1 TP53BP1 TP53BP1 NBN NBN ENSCATP00000018692 ENSCATP00000018692 WEE1 WEE1 DNA2 DNA2 ATR ATR HUS1 HUS1 ENSCATP00000022492 ENSCATP00000022492 ATRIP ATRIP CHEK2 CHEK2 ABRAXAS1 ABRAXAS1 YWHAQ YWHAQ LOC105593181 LOC105593181 BRCC3 BRCC3 LOC105593172 LOC105593172 H2BC21 H2BC21 ENSCATP00000006726 ENSCATP00000006726 CHEK1 CHEK1 RAD9A RAD9A ENSCATP00000006421 ENSCATP00000006421 RMI2 RMI2 ENSCATP00000005937 ENSCATP00000005937 H2BC11 H2BC11 LOC105593167 LOC105593167 H4C11 H4C11 LOC105593174 LOC105593174 LOC105597697 LOC105597697 UBE2NL UBE2NL ENSCATP00000023795 ENSCATP00000023795 H2BC1 H2BC1 H2BC9 H2BC9 LOC105572638 LOC105572638 LOC105572658 LOC105572658 RBBP8 RBBP8 LOC105572655 LOC105572655 EXO1 EXO1 SFN SFN WEE2 WEE2 H2BW1 H2BW1 HUS1B HUS1B LOC105572666 LOC105572666 H2BC5 H2BC5 LOC105572652 LOC105572652 RFC3 RFC3 ENSCATP00000003364 ENSCATP00000003364 LOC105572651 LOC105572651 TOPBP1 TOPBP1 SLF1 SLF1 BRCA1 BRCA1 TOP3A TOP3A UBE2N UBE2N RHNO1 RHNO1 H2BU1 H2BU1 RNF8 RNF8 RNF169 RNF169 BARD1 BARD1 LOC105598099 LOC105598099 RAD1 RAD1 RAD9B RAD9B ENSCATP00000040576 ENSCATP00000040576 CCNB1 CCNB1 YWHAH YWHAH YWHAE YWHAE LOC105597804 LOC105597804 ENSCATP00000039008 ENSCATP00000039008 BRIP1 BRIP1 ENSCATP00000037714 ENSCATP00000037714 HERC2 HERC2 YWHAB YWHAB ENSCATP00000036401 ENSCATP00000036401 MRE11 MRE11 LOC105599742 LOC105599742 UIMC1 UIMC1 BLM BLM WRN WRN ENSCATP00000034029 ENSCATP00000034029 ATM ATM TP53 TP53 RAD17 RAD17 YWHAG YWHAG PIAS4 PIAS4 KAT5 KAT5 CDK1 CDK1 RNF168 RNF168 ENSCATP00000025399 ENSCATP00000025399 LOC105593170 LOC105593170 H2BC3 H2BC3 LOC105572676 LOC105572676 RFC5 RFC5 NSD2 NSD2 H2BC8 H2BC8 MEIOB MEIOB LOC105572671 LOC105572671 LOC105585120 LOC105585120 LOC105593194 LOC105593194 H3-4 H3-4 LOC105572665 LOC105572665 H2BC7 H2BC7 YWHAZ YWHAZ H2BC13 H2BC13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPA3Replication protein A3. (121 aa)
TDRD3Tudor domain containing 3. (744 aa)
RFC4Replication factor C subunit 4. (349 aa)
RFC2Replication factor C subunit 2. (352 aa)
EXD2Exonuclease 3'-5' domain containing 2. (620 aa)
ENSCATP0000001282014_3_3 domain-containing protein; Belongs to the 14-3-3 family. (208 aa)
RECQL4RecQ like helicase 4. (1208 aa)
LOC105583935UBIQUITIN_CONJUGAT_2 domain-containing protein. (87 aa)
CDC25CCell division cycle 25C. (471 aa)
ENSCATP00000013712UBIQUITIN_CONJUGAT_2 domain-containing protein. (140 aa)
BABAM2BRISC and BRCA1 A complex member 2. (415 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (166 aa)
ENSCATP00000015553Histone H2B; Belongs to the histone H2B family. (129 aa)
BABAM1BRISC and BRCA1 A complex member 1. (329 aa)
TP53BP1Tumor protein p53 binding protein 1. (1979 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
ENSCATP00000018692MPN domain-containing protein. (273 aa)
WEE1Wee1-like protein kinase. (646 aa)
DNA2DNA replication helicase/nuclease 2. (1056 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2573 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
ENSCATP00000022492Uncharacterized protein. (65 aa)
ATRIPATR interacting protein. (711 aa)
CHEK2Checkpoint kinase 2. (589 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (412 aa)
YWHAQ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (248 aa)
LOC105593181Histone H2B type 1-M. (126 aa)
BRCC3MPN domain-containing protein. (293 aa)
LOC105593172Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSCATP00000006726UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa)
CHEK1Checkpoint kinase 1. (493 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (390 aa)
ENSCATP00000006421Protein kinase domain-containing protein. (297 aa)
RMI2RecQ mediated genome instability 2. (147 aa)
ENSCATP00000005937UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105593167Histone H2B; Belongs to the histone H2B family. (126 aa)
H4C11Histone H4. (103 aa)
LOC105593174Histone H4. (103 aa)
LOC105597697Histone H2B; Belongs to the histone H2B family. (126 aa)
UBE2NLUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa)
ENSCATP0000002379514_3_3 domain-containing protein; Belongs to the 14-3-3 family. (238 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
H2BC9Histone H2B; Belongs to the histone H2B family. (149 aa)
LOC105572638Histone domain-containing protein; Belongs to the histone H2B family. (127 aa)
LOC105572658Histone H2B; Belongs to the histone H2B family. (126 aa)
RBBP8RB binding protein 8, endonuclease. (905 aa)
LOC105572655Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
EXO1Exonuclease 1. (846 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
WEE2Wee1-like protein kinase. (568 aa)
H2BW1H2B histone family member W, testis specific; Belongs to the histone H2B family. (175 aa)
HUS1BCheckpoint protein; Belongs to the HUS1 family. (277 aa)
LOC105572666Histone H4. (103 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105572652Histone H4. (103 aa)
RFC3Replication factor C subunit 3. (356 aa)
ENSCATP0000000336414_3_3 domain-containing protein; Belongs to the 14-3-3 family. (217 aa)
LOC105572651Histone H4. (103 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1527 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1059 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1871 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (994 aa)
UBE2NUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (240 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (486 aa)
RNF169Ring finger protein 169. (708 aa)
BARD1BRCA1 associated RING domain 1. (777 aa)
LOC105598099UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
RAD1RAD1 checkpoint DNA exonuclease. (280 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (417 aa)
ENSCATP0000004057614_3_3 domain-containing protein; Belongs to the 14-3-3 family. (196 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (433 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
LOC105597804UBIQUITIN_CONJUGAT_2 domain-containing protein. (132 aa)
ENSCATP00000039008Uncharacterized protein. (112 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1217 aa)
ENSCATP0000003771414_3_3 domain-containing protein; Belongs to the 14-3-3 family. (232 aa)
HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4801 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
ENSCATP00000036401Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (262 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
LOC105599742Zinc-hook domain-containing protein. (1192 aa)
UIMC1Ubiquitin interaction motif containing 1. (684 aa)
BLMBLM RecQ like helicase. (1416 aa)
WRNWRN RecQ like helicase. (1418 aa)
ENSCATP00000034029Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (581 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3073 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
RAD17RAD17 checkpoint clamp loader component. (643 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
PIAS4Protein inhibitor of activated STAT 4. (515 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (537 aa)
CDK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (561 aa)
ENSCATP00000025399Histone H2B; Belongs to the histone H2B family. (134 aa)
LOC105593170Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (101 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105572676Histone H4. (103 aa)
RFC5Replication factor C subunit 5. (343 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1365 aa)
H2BC8Histone H2B type 1. (126 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
LOC105572671Histone H4. (103 aa)
LOC105585120Histone H4. (103 aa)
LOC105593194Histone H4. (103 aa)
H3-4Histone cluster 3 H3. (136 aa)
LOC105572665Histone H4. (103 aa)
H2BC7Histone H2B type 1. (126 aa)
YWHAZ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa)
H2BC13Histone H2B; Belongs to the histone H2B family. (136 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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