STRINGSTRING
ENSCATP00000029485 ENSCATP00000029485 H2AZ2 H2AZ2 H2BC1 H2BC1 H2BC9 H2BC9 LOC105572638 LOC105572638 LOC105572658 LOC105572658 LOC105572655 LOC105572655 FEN1 FEN1 POLR2K POLR2K CENPK CENPK H2BW1 H2BW1 LOC105572666 LOC105572666 H2BC5 H2BC5 POLR2E POLR2E CENPQ CENPQ LOC105572652 LOC105572652 LOC105572669 LOC105572669 H2AC6 H2AC6 RFC3 RFC3 LOC105572651 LOC105572651 H2BC3 H2BC3 NPM1 NPM1 LOC105572676 LOC105572676 RFC5 RFC5 H2BC8 H2BC8 MEIOB MEIOB LOC105572671 LOC105572671 H2AJ H2AJ RTEL1 RTEL1 LOC105585120 LOC105585120 ENSCATP00000003984 ENSCATP00000003984 LOC105593194 LOC105593194 H3-4 H3-4 POLR2A POLR2A LOC105572665 LOC105572665 RFC1 RFC1 NOP10 NOP10 H2BC7 H2BC7 LOC105597697 LOC105597697 LOC105593174 LOC105593174 H2AC4 H2AC4 SMARCA1 SMARCA1 H2AC20 H2AC20 H4C11 H4C11 POLR2I POLR2I POLA2 POLA2 LOC105593167 LOC105593167 H2AX H2AX CENPI CENPI H2BC11 H2BC11 CENPW CENPW H2BC21 H2BC21 CENPH CENPH LOC105593172 LOC105593172 GAR1 GAR1 MIS18BP1 MIS18BP1 LOC105593181 LOC105593181 TERF1 TERF1 H2BC13 H2BC13 RPA3 RPA3 ENSCATP00000010284 ENSCATP00000010284 DSCC1 DSCC1 CCNA2 CCNA2 ENSCATP00000010958 ENSCATP00000010958 POT1 POT1 CTC1 CTC1 POLD1 POLD1 CENPM CENPM RFC4 RFC4 PPP6R2 PPP6R2 RFC2 RFC2 EXD2 EXD2 RUVBL1 RUVBL1 PIF1 PIF1 RECQL4 RECQL4 PCNA PCNA H2BC15 H2BC15 PPP6C PPP6C PRIM1 PRIM1 CENPT CENPT CHTF8 CHTF8 ANKRD28 ANKRD28 ENSCATP00000015553 ENSCATP00000015553 CENPN CENPN TRUB1 TRUB1 DKC1 DKC1 RCBTB2 RCBTB2 HJURP HJURP DNA2 DNA2 ENSCATP00000020493 ENSCATP00000020493 LOC105572092 LOC105572092 CENPC CENPC ANKRD44 ANKRD44 POLR2G POLR2G ENSCATP00000021744 ENSCATP00000021744 ENSCATP00000022164 ENSCATP00000022164 MIS18A MIS18A ENSCATP00000023311 ENSCATP00000023311 POLD4 POLD4 CENPO CENPO LOC105593170 LOC105593170 ENSCATP00000025399 ENSCATP00000025399 H3F3A H3F3A ENSCATP00000025894 ENSCATP00000025894 ENSCATP00000026110 ENSCATP00000026110 TERT TERT POLR2D POLR2D ENSCATP00000026830 ENSCATP00000026830 DAXX DAXX PPP6R3 PPP6R3 POLR2B POLR2B ENSCATP00000027778 ENSCATP00000027778 CENPX CENPX RUVBL2 RUVBL2 CENPA CENPA WRAP53 WRAP53 LOC105573488 LOC105573488 ENSCATP00000029353 ENSCATP00000029353 H3F3B H3F3B TERF2IP TERF2IP KNL1 KNL1 TERF2 TERF2 ENSCATP00000031513 ENSCATP00000031513 ENSCATP00000031804 ENSCATP00000031804 CCNA1 CCNA1 LOC105575995 LOC105575995 POLA1 POLA1 ANKRD66 ANKRD66 WRN WRN BLM BLM POLD2 POLD2 ENSCATP00000035826 ENSCATP00000035826 ENSCATP00000035908 ENSCATP00000035908 POLR2C POLR2C OIP5 OIP5 CDK3 CDK3 ENSCATP00000036401 ENSCATP00000036401 POLR2F POLR2F RSF1 RSF1 ITGB3BP ITGB3BP SHQ1 SHQ1 POLR2L POLR2L LOC105575645 LOC105575645 ENSCATP00000039241 ENSCATP00000039241 CENPU CENPU ENSCATP00000039328 ENSCATP00000039328 ENSCATP00000039365 ENSCATP00000039365 RCBTB1 RCBTB1 LIG1 LIG1 CENPL CENPL RBBP7 RBBP7 ENSCATP00000040578 ENSCATP00000040578 CDK2 CDK2 STN1 STN1 H2BU1 H2BU1 POLD3 POLD3 NHP2 NHP2 TEN1 TEN1 TINF2 TINF2 RBBP4 RBBP4 SMARCA5 SMARCA5 CENPP CENPP CHTF18 CHTF18 POLR2H POLR2H
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCATP00000029485Histone H2A; Belongs to the histone H2A family. (117 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (128 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
H2BC9Histone H2B; Belongs to the histone H2B family. (149 aa)
LOC105572638Histone domain-containing protein; Belongs to the histone H2B family. (127 aa)
LOC105572658Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105572655Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
POLR2KRNA polymerase II subunit K. (58 aa)
CENPKCentromere protein K. (269 aa)
H2BW1H2B histone family member W, testis specific; Belongs to the histone H2B family. (175 aa)
LOC105572666Histone H4. (103 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
POLR2ERNA polymerase II subunit E. (210 aa)
CENPQCentromere protein Q. (268 aa)
LOC105572652Histone H4. (103 aa)
LOC105572669Histone H2A; Belongs to the histone H2A family. (130 aa)
H2AC6Histone H2A; Belongs to the histone H2A family. (130 aa)
RFC3Replication factor C subunit 3. (356 aa)
LOC105572651Histone H4. (103 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
NPM1Nucleophosmin 1. (294 aa)
LOC105572676Histone H4. (103 aa)
RFC5Replication factor C subunit 5. (343 aa)
H2BC8Histone H2B type 1. (126 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
LOC105572671Histone H4. (103 aa)
H2AJHistone H2A; Belongs to the histone H2A family. (129 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1352 aa)
LOC105585120Histone H4. (103 aa)
ENSCATP00000003984Uncharacterized protein. (276 aa)
LOC105593194Histone H4. (103 aa)
H3-4Histone cluster 3 H3. (136 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1970 aa)
LOC105572665Histone H4. (103 aa)
RFC1Replication factor C subunit 1. (1113 aa)
NOP10NOP10 ribonucleoprotein. (64 aa)
H2BC7Histone H2B type 1. (126 aa)
LOC105597697Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105593174Histone H4. (103 aa)
H2AC4Histone H2A type 1. (130 aa)
SMARCA1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (1070 aa)
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
H4C11Histone H4. (103 aa)
POLR2IDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
LOC105593167Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
CENPICentromere protein I. (755 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
CENPWCentromere protein W. (103 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
CENPHCentromere protein H. (247 aa)
LOC105593172Histone H2B; Belongs to the histone H2B family. (126 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (218 aa)
MIS18BP1MIS18 binding protein 1. (1131 aa)
LOC105593181Histone H2B type 1-M. (126 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (437 aa)
H2BC13Histone H2B; Belongs to the histone H2B family. (136 aa)
RPA3Replication protein A3. (121 aa)
ENSCATP00000010284Uncharacterized protein. (164 aa)
DSCC1DNA replication and sister chromatid cohesion 1. (374 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
ENSCATP00000010958Histone H3; Belongs to the histone H3 family. (141 aa)
POT1Protection of telomeres 1. (634 aa)
CTC1CST telomere replication complex component 1. (1217 aa)
POLD1DNA polymerase. (1107 aa)
CENPMCentromere protein M. (180 aa)
RFC4Replication factor C subunit 4. (349 aa)
PPP6R2Protein phosphatase 6 regulatory subunit 2. (958 aa)
RFC2Replication factor C subunit 2. (352 aa)
EXD2Exonuclease 3'-5' domain containing 2. (620 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (691 aa)
RECQL4RecQ like helicase 4. (1208 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (166 aa)
PPP6CSerine/threonine-protein phosphatase. (338 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (420 aa)
CENPTCentromere protein T. (561 aa)
CHTF8Chromosome transmission fidelity factor 8. (121 aa)
ANKRD28Ankyrin repeat domain 28. (1059 aa)
ENSCATP00000015553Histone H2B; Belongs to the histone H2B family. (129 aa)
CENPNCentromere protein N. (293 aa)
TRUB1TruB pseudouridine synthase family member 1. (350 aa)
DKC1Dyskerin pseudouridine synthase 1. (514 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (556 aa)
HJURPHolliday junction recognition protein. (728 aa)
DNA2DNA replication helicase/nuclease 2. (1056 aa)
ENSCATP00000020493Uncharacterized protein. (150 aa)
LOC105572092Histone H2A; Belongs to the histone H2A family. (182 aa)
CENPCCentromere protein C. (945 aa)
ANKRD44Ankyrin repeat domain 44. (1004 aa)
POLR2GRNA polymerase II subunit G. (244 aa)
ENSCATP00000021744Uncharacterized protein. (68 aa)
ENSCATP00000022164Histone H2A; Belongs to the histone H2A family. (113 aa)
MIS18AMIS18 kinetochore protein A. (232 aa)
ENSCATP00000023311Histone H2A; Belongs to the histone H2A family. (92 aa)
POLD4Uncharacterized protein. (107 aa)
CENPOCentromere protein O. (299 aa)
LOC105593170Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (101 aa)
ENSCATP00000025399Histone H2B; Belongs to the histone H2B family. (134 aa)
H3F3AH3 histone, family 3A. (136 aa)
ENSCATP00000025894Histone H2A; Belongs to the histone H2A family. (115 aa)
ENSCATP00000026110Uncharacterized protein. (222 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1123 aa)
POLR2DRNA polymerase II subunit D. (142 aa)
ENSCATP00000026830Uncharacterized protein. (233 aa)
DAXXDeath domain associated protein. (739 aa)
PPP6R3Protein phosphatase 6 regulatory subunit 3. (879 aa)
POLR2BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
ENSCATP00000027778WD_REPEATS_REGION domain-containing protein. (356 aa)
CENPXCentromere protein X. (133 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (465 aa)
CENPACentromere protein A. (138 aa)
WRAP53WD repeat containing antisense to TP53. (549 aa)
LOC105573488WD_REPEATS_REGION domain-containing protein. (371 aa)
ENSCATP00000029353Uncharacterized protein. (77 aa)
H3F3BH3 histone, family 3B. (136 aa)
TERF2IPTERF2 interacting protein. (400 aa)
KNL1Kinetochore scaffold 1. (2303 aa)
TERF2Telomeric repeat binding factor 2. (542 aa)
ENSCATP00000031513Uncharacterized protein. (295 aa)
ENSCATP00000031804WD_REPEATS_REGION domain-containing protein. (361 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
LOC105575995WD_REPEATS_REGION domain-containing protein. (430 aa)
POLA1DNA polymerase. (1469 aa)
ANKRD66Ankyrin repeat domain 66. (250 aa)
WRNWRN RecQ like helicase. (1418 aa)
BLMBLM RecQ like helicase. (1416 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
ENSCATP00000035826Uncharacterized protein. (286 aa)
ENSCATP00000035908Uncharacterized protein. (247 aa)
POLR2CRNA polymerase II subunit C. (275 aa)
OIP5Opa interacting protein 5. (229 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
ENSCATP00000036401Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (262 aa)
POLR2FRNA polymerase II subunit F. (158 aa)
RSF1Remodeling and spacing factor 1. (1441 aa)
ITGB3BPIntegrin subunit beta 3 binding protein. (216 aa)
SHQ1SHQ1, H/ACA ribonucleoprotein assembly factor. (577 aa)
POLR2LRNA polymerase II subunit L. (67 aa)
LOC105575645Nucleoplasmin domain-containing protein. (210 aa)
ENSCATP00000039241Uncharacterized protein. (287 aa)
CENPUCentromere protein U. (419 aa)
ENSCATP00000039328Nucleoplasmin domain-containing protein. (209 aa)
ENSCATP00000039365WD_REPEATS_REGION domain-containing protein. (253 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
LIG1DNA ligase. (918 aa)
CENPLCentromere protein L. (390 aa)
RBBP7RB binding protein 7, chromatin remodeling factor. (469 aa)
ENSCATP00000040578Nucleoplasmin domain-containing protein. (217 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
POLD3Uncharacterized protein. (466 aa)
NHP2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa)
TEN1Uncharacterized protein. (123 aa)
TINF2TERF1 interacting nuclear factor 2. (439 aa)
RBBP4WD_REPEATS_REGION domain-containing protein. (424 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa)
CENPPCentromere protein P. (287 aa)
CHTF18Chromosome transmission fidelity factor 18. (1003 aa)
POLR2HRNA polymerase II subunit H. (169 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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