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| | TIAM1 | T cell lymphoma invasion and metastasis 1. (1592 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa) |
| | ARHGEF39 | Uncharacterized protein. (335 aa) |
| | ARHGEF26 | Rho guanine nucleotide exchange factor 26. (869 aa) |
| | TNF | Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa) |
| | ENSCATP00000001361 | DUF4203 domain-containing protein. (100 aa) |
| | UBE2D1 | Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (148 aa) |
| | NAIP | NLR family apoptosis inhibitory protein. (1403 aa) |
| | USP2 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (605 aa) |
| | ARHGEF3 | Rho guanine nucleotide exchange factor 3. (558 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (384 aa) |
| | VAV3 | Vav guanine nucleotide exchange factor 3. (875 aa) |
| | OTULINL | OTU deubiquitinase with linear linkage specificity like. (356 aa) |
| | BEX3 | Brain expressed X-linked 3. (123 aa) |
| | ARHGEF10 | Rho guanine nucleotide exchange factor 10. (1345 aa) |
| | SPATA2 | Spermatogenesis associated 2. (520 aa) |
| | MCF2L2 | MCF.2 cell line derived transforming sequence-like 2. (1066 aa) |
| | ENSCATP00000003612 | Uncharacterized protein. (380 aa) |
| | PLEKHG2 | Pleckstrin homology and RhoGEF domain containing G2. (1388 aa) |
| | CCDC71L | Coiled-coil domain containing 71 like. (235 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa) |
| | RNF31 | Uncharacterized protein. (1072 aa) |
| | ARHGEF4 | Uncharacterized protein. (1816 aa) |
| | SMPD2 | Sphingomyelin phosphodiesterase 2. (423 aa) |
| | BIRC7 | Baculoviral IAP repeat containing 7. (328 aa) |
| | NET1 | Neuroepithelial cell transforming 1. (596 aa) |
| | OBSCN | Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF. (7818 aa) |
| | NGF | Nerve growth factor; Belongs to the NGF-beta family. (309 aa) |
| | UBE2L5 | Ubiquitin conjugating enzyme E2 L5; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | HDAC3 | Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa) |
| | LOC105576738 | Ubiquitin-like domain-containing protein. (134 aa) |
| | OTUD1 | OTU deubiquitinase 1. (479 aa) |
| | CASP2 | Caspase 2; Belongs to the peptidase C14A family. (452 aa) |
| | LINGO2 | Leucine rich repeat and Ig domain containing 2. (606 aa) |
| | LOC105579396 | Ubiquitin-like domain-containing protein. (156 aa) |
| | BAG4 | BCL2 associated athanogene 4. (457 aa) |
| | LOC105595668 | Ubiquitin-like domain-containing protein. (126 aa) |
| | TMEM198 | Transmembrane protein 198. (360 aa) |
| | OMG | Oligodendrocyte myelin glycoprotein. (440 aa) |
| | ULK1 | Unc-51 like autophagy activating kinase 1. (1038 aa) |
| | SESTD1 | SEC14 and spectrin domain containing 1. (696 aa) |
| | BIRC3 | Baculoviral IAP repeat containing 3. (604 aa) |
| | FGD4 | FYVE, RhoGEF and PH domain containing 4. (598 aa) |
| | ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor 6. (776 aa) |
| | CYLD | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa) |
| | ENSCATP00000009298 | Ig-like domain-containing protein. (173 aa) |
| | TNFRSF10A | TNF receptor superfamily member 10a. (471 aa) |
| | GNA13 | G protein subunit alpha 13. (377 aa) |
| | CASP3 | Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa) |
| | XIAP | X-linked inhibitor of apoptosis. (497 aa) |
| | ENSCATP00000011232 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (148 aa) |
| | MADD | MAP kinase activating death domain. (1634 aa) |
| | ARHGEF2 | Rho/Rac guanine nucleotide exchange factor 2. (1031 aa) |
| | KALRN | Kalirin RhoGEF kinase. (2942 aa) |
| | TRADD | TNFRSF1A associated via death domain. (308 aa) |
| | ENSCATP00000011808 | Ubiquitin-like domain-containing protein. (130 aa) |
| | RTN4R | Reticulon 4 receptor. (522 aa) |
| | RASGRF2 | Ras protein specific guanine nucleotide releasing factor 2. (1237 aa) |
| | TRAF6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa) |
| | TIAM2 | T cell lymphoma invasion and metastasis 2. (1725 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa) |
| | STUB1 | STIP1 homology and U-box containing protein 1. (303 aa) |
| | NGFR | Nerve growth factor receptor. (427 aa) |
| | UBE2D4 | Ubiquitin conjugating enzyme E2 D4 (putative); Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | APH1B | Aph-1 homolog B, gamma-secretase subunit. (257 aa) |
| | ARHGEF1 | Rho guanine nucleotide exchange factor 1. (968 aa) |
| | ARHGEF17 | Rho guanine nucleotide exchange factor 17. (2068 aa) |
| | CFLAR | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa) |
| | ARHGEF11 | Rho guanine nucleotide exchange factor 11. (1562 aa) |
| | ARHGEF15 | Rho guanine nucleotide exchange factor 15. (841 aa) |
| | ENSCATP00000016131 | Uncharacterized protein. (244 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | UBA52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa) |
| | ECT2L | Epithelial cell transforming 2 like. (904 aa) |
| | ENSCATP00000017535 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (146 aa) |
| | TGM6 | Transglutaminase 6. (706 aa) |
| | ULK2 | Unc-51 like autophagy activating kinase 2. (931 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | PRKCI | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa) |
| | TRAF1 | TNF receptor-associated factor. (416 aa) |
| | VAV1 | Vav guanine nucleotide exchange factor 1. (856 aa) |
| | BAD | BCL2 associated agonist of cell death. (167 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | MIB2 | Mindbomb E3 ubiquitin protein ligase 2. (1070 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (693 aa) |
| | ARHGEF16 | Rho guanine nucleotide exchange factor 16. (709 aa) |
| | ENSCATP00000019889 | Uncharacterized protein. (329 aa) |
| | ARHGEF40 | Rho guanine nucleotide exchange factor 40. (1519 aa) |
| | AKAP13 | A-kinase anchoring protein 13. (2816 aa) |
| | ENSCATP00000020093 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (433 aa) |
| | APH1A | Aph-1 homolog A, gamma-secretase subunit. (265 aa) |
| | SQSTM1 | Sequestosome 1. (440 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (455 aa) |
| | FASLG | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (961 aa) |
| | SPPL2A | Signal peptide peptidase like 2A. (499 aa) |
| | LINGO1 | Leucine rich repeat and Ig domain containing 1. (620 aa) |
| | ARHGEF7 | Rho guanine nucleotide exchange factor 7. (804 aa) |
| | SMPD3 | Sphingomyelin phosphodiesterase 3. (655 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa) |
| | USP21 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (565 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | ARHGEF5 | Rho guanine nucleotide exchange factor 5. (1597 aa) |
| | ARHGEF12 | Rho guanine nucleotide exchange factor 12. (1544 aa) |
| | CLIP3 | CAP-Gly domain containing linker protein 3. (547 aa) |
| | ENSCATP00000025543 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (121 aa) |
| | VAV2 | Vav guanine nucleotide exchange factor 2. (868 aa) |
| | NCSTN | Nicastrin. (721 aa) |
| | FGD1 | FYVE, RhoGEF and PH domain containing 1. (961 aa) |
| | SHARPIN | SHANK associated RH domain interactor. (383 aa) |
| | OTULIN | OTU deubiquitinase with linear linkage specificity. (368 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (515 aa) |
| | ITSN1 | Intersectin 1. (1723 aa) |
| | ADAM17 | ADAM metallopeptidase domain 17. (824 aa) |
| | ARHGEF10L | Rho guanine nucleotide exchange factor 10 like. (1230 aa) |
| | ENSCATP00000028876 | Uncharacterized protein. (89 aa) |
| | ARHGEF19 | Rho guanine nucleotide exchange factor 19. (779 aa) |
| | RACK1 | Receptor for activated C kinase 1. (393 aa) |
| | SPPL2B | Signal peptide peptidase like 2B. (567 aa) |
| | PSENEN | Presenilin enhancer, gamma-secretase subunit. (101 aa) |
| | PREX1 | Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1661 aa) |
| | UBE2D3 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (149 aa) |
| | PLEKHG5 | Pleckstrin homology and RhoGEF domain containing G5. (1076 aa) |
| | NSMAF | Uncharacterized protein. (936 aa) |
| | USP4 | Ubiquitin specific peptidase 4; Belongs to the peptidase C19 family. (952 aa) |
| | ENSCATP00000029838 | Uncharacterized protein. (929 aa) |
| | ENSCATP00000031033 | Ubiquitin-like domain-containing protein. (149 aa) |
| | WDR31 | WD repeat domain 31. (367 aa) |
| | PSEN1 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa) |
| | TNFRSF10B | TNF receptor superfamily member 10b. (445 aa) |
| | MAP3K20 | Mitogen-activated protein kinase kinase kinase 20. (788 aa) |
| | ENSCATP00000031888 | Uncharacterized protein. (417 aa) |
| | OTUD7B | OTU deubiquitinase 7B. (843 aa) |
| | BIRC2 | Baculoviral IAP repeat containing 2. (618 aa) |
| | MAPKAPK2 | MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | ECT2 | Epithelial cell transforming 2. (917 aa) |
| | MCF2 | MCF.2 cell line derived transforming sequence. (1001 aa) |
| | OPTN | Optineurin. (571 aa) |
| | ENSCATP00000034747 | Uncharacterized protein. (1170 aa) |
| | ENSCATP00000034768 | Ubiquitin-like domain-containing protein. (144 aa) |
| | FGD2 | FYVE, RhoGEF and PH domain containing 2. (655 aa) |
| | ENSCATP00000035134 | Ubiquitin-like domain-containing protein. (146 aa) |
| | RTN4 | Reticulon. (1193 aa) |
| | TGM3 | TGc domain-containing protein. (693 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (550 aa) |
| | TAX1BP1 | Tax1 binding protein 1. (787 aa) |
| | ITGB3BP | Integrin subunit beta 3 binding protein. (216 aa) |
| | NFKBIA | NFKB inhibitor alpha. (317 aa) |
| | RBCK1 | RANBP2-type and C3HC4-type zinc finger containing 1. (510 aa) |
| | ARHGEF9 | Cdc42 guanine nucleotide exchange factor 9. (552 aa) |
| | TNFAIP3 | TNF alpha induced protein 3. (790 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | ENSCATP00000038453 | Uncharacterized protein; Belongs to the peptidase C14A family. (262 aa) |
| | TRIO | Trio Rho guanine nucleotide exchange factor. (3096 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1327 aa) |
| | UBE2D2 | Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa) |
| | NGEF | Neuronal guanine nucleotide exchange factor. (712 aa) |
| | YWHAE | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa) |
| | FAS | Tumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). (331 aa) |
| | MCF2L | MCF.2 cell line derived transforming sequence like. (1154 aa) |
| | ENSCATP00000040576 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (196 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | BCL2L11 | Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa) |
| | ARHGEF38 | Rho guanine nucleotide exchange factor 38. (777 aa) |
| | TNFRSF10D | TNF receptor superfamily member 10d. (383 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (156 aa) |
| | AATF | Apoptosis antagonizing transcription factor. (562 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (474 aa) |
| | PSEN2 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (481 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | TAB3 | TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (586 aa) |
| | ARHGEF37 | Rho guanine nucleotide exchange factor 37. (675 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (721 aa) |
| | FGD3 | FYVE, RhoGEF and PH domain containing 3. (737 aa) |
| | ENSCATP00000043644 | Ubiquitin-like domain-containing protein. (120 aa) |
| | ARHGEF33 | Rho guanine nucleotide exchange factor 33. (837 aa) |
| | ABR | ABR activator of RhoGEF and GTPase. (859 aa) |
| | CLIP4 | CAP-Gly domain containing linker protein family member 4. (705 aa) |
| | MAG | Myelin associated glycoprotein. (772 aa) |
| | PRDM4 | PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation. (801 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | TNFSF10 | Tumor necrosis factor ligand superfamily member. (281 aa) |
