STRINGSTRING
ENSCATP00000030178 ENSCATP00000030178 FGFR4 FGFR4 IRS2 IRS2 ATP6V0C ATP6V0C FGFR2 FGFR2 ATP6V0A2 ATP6V0A2 PIK3R1 PIK3R1 FRS2 FRS2 SHC1 SHC1 PIK3CA PIK3CA FGF6 FGF6 ATP6V0E1 ATP6V0E1 ATP6V1H ATP6V1H ATP6V1G2 ATP6V1G2 TRIB3 TRIB3 LOC105585293 LOC105585293 PIK3CB PIK3CB PIK3R2 PIK3R2 FGF4 FGF4 LIM2 LIM2 GAB2 GAB2 FGFR3 FGFR3 PTPN11 PTPN11 ATP6V1C2 ATP6V1C2 ATP6V1A ATP6V1A ATP6V1F ATP6V1F ATP6V0D1 ATP6V0D1 PDPK1 PDPK1 ATP6V0D2 ATP6V0D2 THEM4 THEM4 FGF1 FGF1 ATP6V1B1 ATP6V1B1 FGF8 FGF8 MAPK1 MAPK1 ATP6V0A1 ATP6V0A1 ATP6V1G1 ATP6V1G1 TCIRG1 TCIRG1 HRAS HRAS GAB4 GAB4 FGF16 FGF16 CTSD CTSD IRS1 IRS1 KRAS KRAS MAPK3 MAPK3 FGF9 FGF9 SPEM2 SPEM2 GRB10 GRB10 KLB KLB FGF3 FGF3 INSR INSR ENSCATP00000007407 ENSCATP00000007407 GAB1 GAB1 ENSCATP00000005869 ENSCATP00000005869 ERAS ERAS SOS1 SOS1 ATP6V1E2 ATP6V1E2 FLT3 FLT3 ATP6V1G3 ATP6V1G3 ENSCATP00000002233 ENSCATP00000002233 FGF20 FGF20 FGF2 FGF2 ATP6V0B ATP6V0B ATP6V1C1 ATP6V1C1 FGF22 FGF22 PIK3C3 PIK3C3 PTPRF PTPRF TLR9 TLR9 ATP6V0A4 ATP6V0A4 FGF7 FGF7 FGFR1 FGFR1 ENSCATP00000041601 ENSCATP00000041601 ATP6V1D ATP6V1D GRB2 GRB2 SPEM1 SPEM1 INS INS FLT3LG FLT3LG ENSCATP00000044421 ENSCATP00000044421 KL KL ATP6V0E2 ATP6V0E2 ATP6V1B2 ATP6V1B2 FGF17 FGF17 FGF5 FGF5 CNST CNST ENSCATP00000036888 ENSCATP00000036888 NRAS NRAS ATP6AP1L ATP6AP1L FGF18 FGF18 ATP6V1E1 ATP6V1E1 PTPN1 PTPN1 ATP6AP1 ATP6AP1 IDE IDE AKT2 AKT2 FGF23 FGF23 FGF10 FGF10 FGF19 FGF19 NRDC NRDC PIK3R4 PIK3R4 PDE3B PDE3B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCATP00000030178Uncharacterized protein. (218 aa)
FGFR4Fibroblast growth factor receptor. (802 aa)
IRS2Insulin receptor substrate 2. (1338 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
SHC1SHC adaptor protein 1. (584 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
ATP6V0E1V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (472 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (158 aa)
TRIB3Tribbles pseudokinase 3. (385 aa)
LOC105585293Uncharacterized protein. (290 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
PIK3R2Uncharacterized protein. (624 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
LIM2Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. (215 aa)
GAB2GRB2 associated binding protein 2. (676 aa)
FGFR3Fibroblast growth factor receptor. (809 aa)
PTPN11Protein tyrosine phosphatase non-receptor type 11. (552 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (437 aa)
ATP6V1AATPase H+ transporting V1 subunit A. (617 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (134 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (392 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (534 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
THEM4Thioesterase superfamily member 4. (240 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (803 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
GAB4GRB2 associated binding protein family member 4. (536 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
CTSDCathepsin D; Belongs to the peptidase A1 family. (603 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SPEM2SPEM family member 2. (505 aa)
GRB10Growth factor receptor bound protein 10. (593 aa)
KLBKlotho beta. (1044 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
INSRTyrosine-protein kinase receptor. (1339 aa)
ENSCATP00000007407PID domain-containing protein. (502 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
ENSCATP00000005869Uncharacterized protein. (526 aa)
ERASES cell expressed Ras. (233 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
ATP6V1E2ATPase H+ transporting V1 subunit E2. (226 aa)
FLT3Fms related tyrosine kinase 3. (741 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (124 aa)
ENSCATP00000002233Uncharacterized protein. (198 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (259 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (891 aa)
PTPRFProtein tyrosine phosphatase receptor type F. (1963 aa)
TLR9TIR domain-containing protein. (1033 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (838 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
ENSCATP00000041601V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
ATP6V1DATPase H+ transporting V1 subunit D. (249 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
SPEM1Spermatid maturation 1. (309 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
FLT3LGFms related tyrosine kinase 3 ligand. (236 aa)
ENSCATP00000044421Uncharacterized protein. (441 aa)
KLKlotho. (1001 aa)
ATP6V0E2ATPase H+ transporting V0 subunit e2. (212 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (540 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
CNSTConsortin, connexin sorting protein. (726 aa)
ENSCATP00000036888Uncharacterized protein. (179 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ATP6AP1LATPase H+ transporting accessory protein 1 like. (341 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ATP6V1E1ATPase H+ transporting V1 subunit E1. (226 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (470 aa)
IDEInsulin degrading enzyme; Belongs to the peptidase M16 family. (1019 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
NRDCNardilysin convertase. (1219 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
PDE3BPhosphodiesterase. (1117 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.