STRINGSTRING
PSPN PSPN NXPE1 NXPE1 ENSCATP00000044421 ENSCATP00000044421 GFRA3 GFRA3 PRKACA PRKACA LDB3 LDB3 FNDC3A FNDC3A GRB2 GRB2 SHC3 SHC3 DOK2 DOK2 PRKACB PRKACB GRB7 GRB7 PIK3CD PIK3CD GFRA4 GFRA4 DOK6 DOK6 GDNF GDNF NRTN NRTN IRS2 IRS2 DOK4 DOK4 PIK3R1 PIK3R1 FRS2 FRS2 PIK3R3 PIK3R3 SHC1 SHC1 PIK3CA PIK3CA RET RET LOC105585293 LOC105585293 PIK3CB PIK3CB PIK3R2 PIK3R2 PLCG1 PLCG1 GFRA1 GFRA1 GAB2 GAB2 MAPK7 MAPK7 NXPE4 NXPE4 PTPN11 PTPN11 RAP1GAP RAP1GAP PRKCA PRKCA GAB4 GAB4 ARTN ARTN GFRA2 GFRA2 DOK5 DOK5 GRB10 GRB10 PDLIM7 PDLIM7 PDLIM5 PDLIM5 ENSCATP00000007407 ENSCATP00000007407 SHANK3 SHANK3 GAB1 GAB1 ENSCATP00000005869 ENSCATP00000005869 FNDC3B FNDC3B SRC SRC SOS1 SOS1 DOK1 DOK1 NXPE2 NXPE2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSPNPersephin. (156 aa)
NXPE1Neurexophilin and PC-esterase domain family member 1. (503 aa)
ENSCATP00000044421Uncharacterized protein. (441 aa)
GFRA3GDNF family receptor alpha 3. (403 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
LDB3LIM domain binding 3. (735 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
SHC3SHC adaptor protein 3. (598 aa)
DOK2Docking protein 2. (412 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GRB7Growth factor receptor bound protein 7. (558 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GFRA4GDNF family receptor alpha 4. (268 aa)
DOK6Docking protein 6. (331 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
NRTNNeurturin. (197 aa)
IRS2Insulin receptor substrate 2. (1338 aa)
DOK4Docking protein 4. (326 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
SHC1SHC adaptor protein 1. (584 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1115 aa)
LOC105585293Uncharacterized protein. (290 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
PIK3R2Uncharacterized protein. (624 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
GFRA1GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. (481 aa)
GAB2GRB2 associated binding protein 2. (676 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
NXPE4Neurexophilin and PC-esterase domain family member 4. (544 aa)
PTPN11Protein tyrosine phosphatase non-receptor type 11. (552 aa)
RAP1GAPRAP1 GTPase activating protein. (754 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
GAB4GRB2 associated binding protein family member 4. (536 aa)
ARTNArtemin. (220 aa)
GFRA2GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. (464 aa)
DOK5Docking protein 5. (306 aa)
GRB10Growth factor receptor bound protein 10. (593 aa)
PDLIM7PDZ and LIM domain 7. (485 aa)
PDLIM5PDZ and LIM domain 5. (566 aa)
ENSCATP00000007407PID domain-containing protein. (502 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1739 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
ENSCATP00000005869Uncharacterized protein. (526 aa)
FNDC3BFibronectin type III domain containing 3B. (1158 aa)
SRCTyrosine-protein kinase. (644 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
DOK1Docking protein 1. (553 aa)
NXPE2Neurexophilin and PC-esterase domain family member 2. (559 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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