STRINGSTRING
PIK3CB PIK3CB GRB2 GRB2 PIK3R5 PIK3R5 PIK3CD PIK3CD EPOR EPOR NRAS NRAS PIK3CG PIK3CG CRKL CRKL STAT5A STAT5A PLCG1 PLCG1 PLCG2 PLCG2 VAV1 VAV1 HRAS HRAS LYN LYN KRAS KRAS RAPGEF1 RAPGEF1 JAK2 JAK2 ENSCATP00000007407 ENSCATP00000007407 GAB1 GAB1 ERAS ERAS SOS1 SOS1 STAT5B STAT5B EPO EPO IRS2 IRS2 PIK3R1 PIK3R1 LOC105585293 LOC105585293 PIK3CA PIK3CA SHC1 SHC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (880 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
EPORErythropoietin receptor; Receptor for erythropoietin. (508 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1236 aa)
VAV1Vav guanine nucleotide exchange factor 1. (856 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
LYNTyrosine-protein kinase. (507 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1303 aa)
JAK2Tyrosine-protein kinase. (1137 aa)
ENSCATP00000007407PID domain-containing protein. (502 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
ERASES cell expressed Ras. (233 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
IRS2Insulin receptor substrate 2. (1338 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
LOC105585293Uncharacterized protein. (290 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
SHC1SHC adaptor protein 1. (584 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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