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| | PSMC6 | AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa) |
| | IL1R2 | Interleukin 1 receptor type 2. (398 aa) |
| | S100A12 | S100 calcium binding protein A12; Belongs to the S-100 family. (90 aa) |
| | PSME4 | Proteasome activator subunit 4. (1792 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | PSME2 | Proteasome activator subunit 2. (239 aa) |
| | NLRX1 | NLR family member X1. (794 aa) |
| | UBE2N | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | ENSCATP00000043644 | Ubiquitin-like domain-containing protein. (120 aa) |
| | NKIRAS2 | NFKB inhibitor interacting Ras like 2. (198 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (721 aa) |
| | PSMD5 | Proteasome 26S subunit, non-ATPase 5. (508 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa) |
| | PSMB5 | Proteasome subunit beta. (263 aa) |
| | IL1R1 | Interleukin 1 receptor type 1. (569 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (586 aa) |
| | TAB3 | TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | LRRC74A | Leucine rich repeat containing 74A. (488 aa) |
| | LOC105598876 | Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa) |
| | PSMD11 | Proteasome 26S subunit, non-ATPase 11. (422 aa) |
| | PSME3 | Proteasome activator subunit 3. (265 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (156 aa) |
| | ENSCATP00000041490 | AAA domain-containing protein; Belongs to the AAA ATPase family. (199 aa) |
| | NFKBIB | NFKB inhibitor beta. (356 aa) |
| | LOC105598099 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | ENSCATP00000040310 | ANK_REP_REGION domain-containing protein. (159 aa) |
| | LOC105597804 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (132 aa) |
| | APP | Amyloid beta precursor protein. (770 aa) |
| | PSMD14 | Proteasome 26S subunit, non-ATPase 14. (315 aa) |
| | PSMC4 | Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa) |
| | LOC105587074 | Uncharacterized protein. (186 aa) |
| | PSMD13 | Proteasome 26S subunit, non-ATPase 13. (379 aa) |
| | LRRC34 | Leucine rich repeat containing 34. (464 aa) |
| | SKP1 | S-phase kinase associated protein 1; Belongs to the SKP1 family. (165 aa) |
| | PSMB9 | Proteasome subunit beta. (219 aa) |
| | PSMA4 | Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (307 aa) |
| | BTRC | Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa) |
| | ENSCATP00000037667 | Protein kinase domain-containing protein. (365 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (416 aa) |
| | PSMB6 | Proteasome subunit beta. (285 aa) |
| | ENSCATP00000037470 | AAA domain-containing protein. (389 aa) |
| | NLRC5 | NLR family CARD domain containing 5. (1774 aa) |
| | NFKBIA | NFKB inhibitor alpha. (317 aa) |
| | PSMD3 | Proteasome 26S subunit, non-ATPase 3. (534 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (776 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (550 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (271 aa) |
| | IL1RN | Interleukin-1. (178 aa) |
| | ENSCATP00000035134 | Ubiquitin-like domain-containing protein. (146 aa) |
| | ENSCATP00000035052 | Uncharacterized protein. (211 aa) |
| | ENSCATP00000034768 | Ubiquitin-like domain-containing protein. (144 aa) |
| | ENSCATP00000034742 | JAB_MPN domain-containing protein. (166 aa) |
| | ENSCATP00000034500 | Uncharacterized protein. (464 aa) |
| | IL1RAP | Interleukin 1 receptor accessory protein. (687 aa) |
| | LRRC45 | Leucine rich repeat containing 45. (670 aa) |
| | PSMA8 | Proteasome subunit alpha type. (250 aa) |
| | PSMC2 | Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (465 aa) |
| | PSMA3 | Proteasome subunit alpha type. (255 aa) |
| | LRRC14 | Leucine rich repeat containing 14. (493 aa) |
| | PSMB4 | Proteasome subunit beta; Belongs to the peptidase T1B family. (274 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa) |
| | MAP3K20 | Mitogen-activated protein kinase kinase kinase 20. (788 aa) |
| | PSMB2 | Proteasome subunit beta. (201 aa) |
| | ALPK1 | Alpha kinase 1. (1244 aa) |
| | NLRP6 | NLR family pyrin domain containing 6. (1044 aa) |
| | ENSCATP00000031033 | Ubiquitin-like domain-containing protein. (149 aa) |
| | NOD1 | Nucleotide binding oligomerization domain containing 1. (953 aa) |
| | PSMC1 | Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (344 aa) |
| | S100B | S_100 domain-containing protein; Belongs to the S-100 family. (94 aa) |
| | PSMA6 | Proteasome subunit alpha type. (246 aa) |
| | PSMD8 | Proteasome 26S subunit, non-ATPase 8. (350 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa) |
| | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (515 aa) |
| | N4BP1 | NEDD4 binding protein 1. (896 aa) |
| | RBX1 | Ring-box 1. (108 aa) |
| | TONSL | Tonsoku like, DNA repair protein. (1390 aa) |
| | PSMB1 | Proteasome subunit beta. (241 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8. (572 aa) |
| | NLRP9 | NLR family pyrin domain containing 9. (992 aa) |
| | AGER | Advanced glycosylation end-product specific receptor. (403 aa) |
| | NKIRAS1 | NFKB inhibitor interacting Ras like 1. (192 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa) |
| | IRAK3 | Interleukin 1 receptor associated kinase 3. (596 aa) |
| | IRAK2 | Interleukin 1 receptor associated kinase 2. (625 aa) |
| | PELI3 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa) |
| | PSMD9 | PDZ domain-containing protein. (223 aa) |
| | PSME1 | Proteasome activator subunit 1. (249 aa) |
| | SQSTM1 | Sequestosome 1. (440 aa) |
| | ENSCATP00000021172 | Uncharacterized protein. (278 aa) |
| | PSMC5 | Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa) |
| | ENSCATP00000020357 | AAA domain-containing protein; Belongs to the AAA ATPase family. (414 aa) |
| | PSMB7 | Proteasome subunit beta. (277 aa) |
| | ENSCATP00000020004 | Uncharacterized protein; Belongs to the SKP1 family. (198 aa) |
| | NFKB2 | Nuclear factor kappa B subunit 2. (900 aa) |
| | LOC105598877 | Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (130 aa) |
| | PSMD10 | Proteasome 26S subunit, non-ATPase 10. (226 aa) |
| | PSMA5 | Proteasome subunit alpha type. (241 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | PSMD12 | Proteasome 26S subunit, non-ATPase 12. (456 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa) |
| | PSMB10 | Proteasome subunit beta. (273 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1044 aa) |
| | NLRP13 | NLR family pyrin domain containing 13. (1044 aa) |
| | LOC105579883 | Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (238 aa) |
| | UBA52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa) |
| | ENSCATP00000016481 | AAA domain-containing protein. (370 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | MFSD1 | Major facilitator superfamily domain containing 1. (514 aa) |
| | ENSCATP00000016334 | Uncharacterized protein. (338 aa) |
| | LOC105598875 | Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa) |
| | ENSCATP00000015253 | AAA domain-containing protein. (373 aa) |
| | TOLLIP | Toll interacting protein. (274 aa) |
| | PSMB3 | Proteasome subunit beta. (205 aa) |
| | PELI1 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa) |
| | PELI2 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (420 aa) |
| | ENSCATP00000014541 | Prot_ATP_ID_OB domain-containing protein. (172 aa) |
| | MAP3K3 | Mitogen-activated protein kinase kinase kinase 3. (657 aa) |
| | ENSCATP00000013712 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (140 aa) |
| | LOC105583935 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (87 aa) |
| | PSMD4 | Proteasome 26S subunit, non-ATPase 4. (363 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa) |
| | TRAF6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa) |
| | PSMD6 | Proteasome 26S subunit, non-ATPase 6. (442 aa) |
| | ENSCATP00000011971 | Uncharacterized protein. (191 aa) |
| | ENSCATP00000011808 | Ubiquitin-like domain-containing protein. (130 aa) |
| | ENSCATP00000011745 | AAA domain-containing protein. (410 aa) |
| | LRRC31 | Leucine rich repeat containing 31. (552 aa) |
| | KHNYN | KH and NYN domain containing. (678 aa) |
| | ENSCATP00000010732 | CSN8_PSD8_EIF3K domain-containing protein. (249 aa) |
| | PSMA2 | Proteasome subunit alpha type. (234 aa) |
| | PSMB8 | Proteasome subunit beta. (276 aa) |
| | ENSCATP00000008212 | Uncharacterized protein. (145 aa) |
| | PSMD7 | Proteasome 26S subunit, non-ATPase 7. (324 aa) |
| | LOC105595668 | Ubiquitin-like domain-containing protein. (126 aa) |
| | LOC105579396 | Ubiquitin-like domain-containing protein. (156 aa) |
| | PSMC3 | AAA domain-containing protein; Belongs to the AAA ATPase family. (439 aa) |
| | LOC105576738 | Ubiquitin-like domain-containing protein. (134 aa) |
| | HMGB1 | High mobility group box 1. (215 aa) |
| | ENSCATP00000004934 | ATPase_AAA_core domain-containing protein; Belongs to the AAA ATPase family. (177 aa) |
| | PSMF1 | Proteasome inhibitor subunit 1. (271 aa) |
| | UBE2NL | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa) |
| | PSMA1 | Proteasome subunit alpha type. (269 aa) |
| | USP14 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (486 aa) |
| | CCDC71L | Coiled-coil domain containing 71 like. (235 aa) |
| | ENSCATP00000003644 | ANK_REP_REGION domain-containing protein. (116 aa) |
| | PSMA7 | Proteasome subunit alpha type. (248 aa) |
| | TNIP2 | CCHC NOA-type domain-containing protein. (346 aa) |
| | MAP3K2 | Mitogen-activated protein kinase kinase kinase 2. (619 aa) |
| | LRRC71 | Leucine rich repeat containing 71. (559 aa) |
| | PSMB11 | Proteasome subunit beta. (300 aa) |
| | LOC105581053 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (147 aa) |
| | VWC2 | Von Willebrand factor C domain containing 2. (325 aa) |
| | ENSCATP00000001061 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (147 aa) |
| | ENSCATP00000000678 | Uncharacterized protein. (211 aa) |
| | TIFA | TRAF interacting protein with forkhead associated domain. (185 aa) |
| | ENSCATP00000000464 | CCHC NOA-type domain-containing protein. (363 aa) |
| | FBXW11 | F-box and WD repeat domain containing 11. (563 aa) |
| | ENSCATP00000000117 | Uncharacterized protein. (93 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa) |
| | ENSCATP00000000012 | Protein kinase domain-containing protein. (231 aa) |
