STRINGSTRING
ENSCATP00000002799 ENSCATP00000002799 RBL2 RBL2 SMAD3 SMAD3 BCL6B BCL6B SMAD2 SMAD2 G6PC G6PC SFN SFN GDF11 GDF11 INS INS HDAC1 HDAC1 KLF2 KLF2 EP300 EP300 BCL2L11 BCL2L11 SIRT3 SIRT3 HDAC2 HDAC2 NFYB NFYB ENSCATP00000039607 ENSCATP00000039607 AGRP AGRP SOD2 SOD2 ENSCATP00000037714 ENSCATP00000037714 NR3C1 NR3C1 MSTN MSTN SREBF1 SREBF1 STK11 STK11 SMAD4 SMAD4 POMC POMC YWHAB YWHAB GADD45A GADD45A SIRT1 SIRT1 ENSCATP00000036022 ENSCATP00000036022 PLXNA4 PLXNA4 CREBBP CREBBP CDKN1B CDKN1B FOXO3 FOXO3 AKT2 AKT2 ENSCATP00000031520 ENSCATP00000031520 YWHAG YWHAG GCK GCK BCL6 BCL6 RETN RETN ABCA6 ABCA6 ATXN3 ATXN3 FOXO1 FOXO1 IGFBP1 IGFBP1 FBXO32 FBXO32 ENSCATP00000025219 ENSCATP00000025219 TXNIP TXNIP ENSCATP00000023795 ENSCATP00000023795 FASLG FASLG CAT CAT TXN TXN SIN3A SIN3A ENSCATP00000020093 ENSCATP00000020093 TRIM63 TRIM63 AKT3 AKT3 FOXO4 FOXO4 KAT2B KAT2B NFYC NFYC PPARGC1A PPARGC1A NFYA NFYA CITED2 CITED2 PCBP4 PCBP4 CCNG2 CCNG2 ENSCATP00000012820 ENSCATP00000012820 BTG1 BTG1 PINK1 PINK1 FOXO6 FOXO6 DDIT3 DDIT3 YWHAZ YWHAZ YWHAQ YWHAQ ENSCATP00000007492 ENSCATP00000007492 PCK1 PCK1 AKT1 AKT1 KLF4 KLF4 FOXG1 FOXG1 CDKN1A CDKN1A ENSCATP00000003364 ENSCATP00000003364
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCATP00000002799Thioredoxin; Belongs to the thioredoxin family. (101 aa)
RBL2RB transcriptional corepressor like 2. (1139 aa)
SMAD3Mothers against decapentaplegic homolog. (429 aa)
BCL6BBCL6B transcription repressor. (474 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
GDF11Growth differentiation factor 11. (406 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
KLF2Kruppel like factor 2. (355 aa)
EP300E1A binding protein p300. (2411 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (399 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
NFYBCBFD_NFYB_HMF domain-containing protein. (208 aa)
ENSCATP00000039607CBFD_NFYB_HMF domain-containing protein. (280 aa)
AGRPAgouti related neuropeptide. (132 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (232 aa)
ENSCATP0000003771414_3_3 domain-containing protein; Belongs to the 14-3-3 family. (232 aa)
NR3C1Nuclear receptor subfamily 3 group C member 1. (778 aa)
MSTNMyostatin. (376 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
POMCProopiomelanocortin. (265 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
SIRT1Sirtuin 1. (744 aa)
ENSCATP00000036022Thioredoxin; Belongs to the thioredoxin family. (106 aa)
PLXNA4Plexin A4. (1894 aa)
CREBBPCREB binding protein. (2442 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
FOXO3Forkhead box O3. (672 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSCATP00000031520CBFD_NFYB_HMF domain-containing protein. (193 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
GCKPhosphotransferase. (480 aa)
BCL6BCL6 transcription repressor. (706 aa)
RETNResistin. (108 aa)
ABCA6ATP binding cassette subfamily A member 6. (1600 aa)
ATXN3Ataxin 3. (366 aa)
FOXO1Forkhead box O1. (655 aa)
IGFBP1Insulin like growth factor binding protein 1. (281 aa)
FBXO32F-box protein 32. (355 aa)
ENSCATP00000025219Thioredoxin domain-containing protein. (94 aa)
TXNIPThioredoxin interacting protein. (391 aa)
ENSCATP0000002379514_3_3 domain-containing protein; Belongs to the 14-3-3 family. (238 aa)
FASLGTumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
SIN3ASIN3 transcription regulator family member A. (1273 aa)
ENSCATP00000020093Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (433 aa)
TRIM63Tripartite motif containing 63. (383 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
FOXO4Forkhead box O4. (505 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (832 aa)
NFYCNuclear transcription factor Y subunit gamma. (439 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
NFYANuclear transcription factor Y subunit alpha. (347 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
PCBP4Poly(rC) binding protein 4. (435 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (334 aa)
ENSCATP0000001282014_3_3 domain-containing protein; Belongs to the 14-3-3 family. (208 aa)
BTG1BTG anti-proliferation factor 1. (171 aa)
PINK1PTEN induced kinase 1. (581 aa)
FOXO6Forkhead box O6. (626 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
YWHAZ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa)
YWHAQ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (248 aa)
ENSCATP00000007492Anti_prolifrtn domain-containing protein. (171 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
KLF4Kruppel like factor 4. (479 aa)
FOXG1Forkhead box G1. (489 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ENSCATP0000000336414_3_3 domain-containing protein; Belongs to the 14-3-3 family. (217 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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