(19 nodes) TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling network (Cercocebus atys)

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Your Input:
	ENSCATP00000034768	Ubiquitin-like domain-containing protein. (144 aa)
	UBA52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
	IRAK4	Interleukin 1 receptor associated kinase 4. (460 aa)
	ENSCATP00000031033	Ubiquitin-like domain-containing protein. (149 aa)
	IRF7	Interferon regulatory factor 7. (517 aa)
	ENSCATP00000013712	UBIQUITIN_CONJUGAT_2 domain-containing protein. (140 aa)
	LOC105583935	UBIQUITIN_CONJUGAT_2 domain-containing protein. (87 aa)
	TRAF6	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa)
	LOC105579396	Ubiquitin-like domain-containing protein. (156 aa)
	UBE2NL	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (156 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (721 aa)
	UBE2N	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
	TLR7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
	LOC105598099	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
	TLR9	TIR domain-containing protein. (1033 aa)
	LOC105597804	UBIQUITIN_CONJUGAT_2 domain-containing protein. (132 aa)
	ENSCATP00000035134	Ubiquitin-like domain-containing protein. (146 aa)

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCATP00000013712	ENSCATP00000031033	ENSCATP00000013712	ENSCATP00000031033	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.653
ENSCATP00000013712	ENSCATP00000034768	ENSCATP00000013712	ENSCATP00000034768	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.653
ENSCATP00000013712	ENSCATP00000035134	ENSCATP00000013712	ENSCATP00000035134	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.653
ENSCATP00000013712	IRAK1	ENSCATP00000013712	ENSCATP00000043465	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Interleukin 1 receptor associated kinase 1.	0.521
ENSCATP00000013712	IRAK4	ENSCATP00000013712	ENSCATP00000025028	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Interleukin 1 receptor associated kinase 4.	0.571
ENSCATP00000013712	LOC105579396	ENSCATP00000013712	ENSCATP00000007127	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.653
ENSCATP00000013712	RPS27A	ENSCATP00000013712	ENSCATP00000041739	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.653
ENSCATP00000013712	TRAF6	ENSCATP00000013712	ENSCATP00000012971	UBIQUITIN_CONJUGAT_2 domain-containing protein.	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]	0.875
ENSCATP00000013712	UBA52	ENSCATP00000013712	ENSCATP00000016767	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.763
ENSCATP00000031033	ENSCATP00000013712	ENSCATP00000031033	ENSCATP00000013712	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.653
ENSCATP00000031033	IRAK1	ENSCATP00000031033	ENSCATP00000043465	Ubiquitin-like domain-containing protein.	Interleukin 1 receptor associated kinase 1.	0.430
ENSCATP00000031033	LOC105583935	ENSCATP00000031033	ENSCATP00000013535	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.653
ENSCATP00000031033	LOC105597804	ENSCATP00000031033	ENSCATP00000039950	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.653
ENSCATP00000031033	LOC105598099	ENSCATP00000031033	ENSCATP00000040839	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.653
ENSCATP00000031033	TRAF6	ENSCATP00000031033	ENSCATP00000012971	Ubiquitin-like domain-containing protein.	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]	0.860
ENSCATP00000031033	UBA52	ENSCATP00000031033	ENSCATP00000016767	Ubiquitin-like domain-containing protein.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.986
ENSCATP00000031033	UBE2N	ENSCATP00000031033	ENSCATP00000043671	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.653
ENSCATP00000031033	UBE2NL	ENSCATP00000031033	ENSCATP00000004609	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.653
ENSCATP00000034768	ENSCATP00000013712	ENSCATP00000034768	ENSCATP00000013712	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.653
ENSCATP00000034768	IRAK1	ENSCATP00000034768	ENSCATP00000043465	Ubiquitin-like domain-containing protein.	Interleukin 1 receptor associated kinase 1.	0.430