147 items (Cercocebus atys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105595668	Ubiquitin-like domain-containing protein. (126 aa)
	CSNK2A1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
	PSMD11	Proteasome 26S subunit, non-ATPase 11. (422 aa)
	EP300	E1A binding protein p300. (2411 aa)
	PSME3	Proteasome activator subunit 3. (265 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (156 aa)
	ENSCATP00000041490	AAA domain-containing protein; Belongs to the AAA ATPase family. (199 aa)
	PRDX1	Peroxiredoxin 1. (199 aa)
	ENSCATP00000040310	ANK_REP_REGION domain-containing protein. (159 aa)
	PSMD14	Proteasome 26S subunit, non-ATPase 14. (315 aa)
	PSMC4	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
	UFD1	Uncharacterized protein. (309 aa)
	IDH1	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (417 aa)
	PSMD13	Proteasome 26S subunit, non-ATPase 13. (379 aa)
	PALB2	Partner and localizer of BRCA2. (1192 aa)
	ENSCATP00000038840	1-cysPrx_C domain-containing protein. (94 aa)
	SKP1	S-phase kinase associated protein 1; Belongs to the SKP1 family. (165 aa)
	PSMB9	Proteasome subunit beta. (219 aa)
	PSMA4	Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (307 aa)
	BTRC	Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
	PSMB6	Proteasome subunit beta. (285 aa)
	ENSCATP00000037470	AAA domain-containing protein. (389 aa)
	PSMD3	Proteasome 26S subunit, non-ATPase 3. (534 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (776 aa)
	NFE2L1	Nuclear factor, erythroid 2 like 1. (772 aa)
	CSNK2B	Uncharacterized protein. (298 aa)
	SRXN1	Sulfiredoxin. (137 aa)
	ENSCATP00000035134	Ubiquitin-like domain-containing protein. (146 aa)
	NFE2L3	Nuclear factor, erythroid 2 like 3. (694 aa)
	ENSCATP00000035052	Uncharacterized protein. (211 aa)
	ENSCATP00000034768	Ubiquitin-like domain-containing protein. (144 aa)
	ENSCATP00000034742	JAB_MPN domain-containing protein. (166 aa)
	TXNRD3	Thioredoxin reductase 3. (611 aa)
	PSMA8	Proteasome subunit alpha type. (250 aa)
	PSMC2	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (465 aa)
	CREBBP	CREB binding protein. (2442 aa)
	PSMA3	Proteasome subunit alpha type. (255 aa)
	PSMB4	Proteasome subunit beta; Belongs to the peptidase T1B family. (274 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (768 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	PSMB2	Proteasome subunit beta. (201 aa)
	TRIM58	Tripartite motif containing 58. (486 aa)
	ENSCATP00000031033	Ubiquitin-like domain-containing protein. (149 aa)
	PSMC1	Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
	MAFK	MAF bZIP transcription factor K. (156 aa)
	PSMA6	Proteasome subunit alpha type. (246 aa)
	FBXL17	F-box and leucine rich repeat protein 17. (702 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
	PSMD8	Proteasome 26S subunit, non-ATPase 8. (350 aa)
	PSMD1	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
	ENSCATP00000028070	Uncharacterized protein. (293 aa)
	TKT	Transketolase. (631 aa)
	PSMD2	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
	BACH2	BTB domain and CNC homolog 2. (842 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (606 aa)
	NPLOC4	NPL4 homolog, ubiquitin recognition factor. (570 aa)
	SPATA5	Spermatogenesis associated 5. (852 aa)
	RBX1	Ring-box 1. (108 aa)
	PSMB1	Proteasome subunit beta. (241 aa)
	TALDO1	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (337 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (440 aa)
	PSMD9	PDZ domain-containing protein. (223 aa)
	TXNRD1	Thioredoxin reductase 1. (648 aa)
	MAP1LC3B	Uncharacterized protein. (125 aa)
	PSME1	Proteasome activator subunit 1. (249 aa)
	SQSTM1	Sequestosome 1. (440 aa)
	ENSCATP00000021172	Uncharacterized protein. (278 aa)
	KIAA2012	KIAA2012. (1180 aa)
	SKP2	S-phase kinase associated protein 2. (437 aa)
	ENSCATP00000021067	Uncharacterized protein. (111 aa)
	PSMC5	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
	ENSCATP00000020357	AAA domain-containing protein; Belongs to the AAA ATPase family. (414 aa)
	PSMB7	Proteasome subunit beta. (277 aa)
	ENSCATP00000020004	Uncharacterized protein; Belongs to the SKP1 family. (198 aa)
	SPATA5L1	Spermatogenesis associated 5 like 1. (740 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	PSMD10	Proteasome 26S subunit, non-ATPase 10. (226 aa)
	PSMA5	Proteasome subunit alpha type. (241 aa)
	GCLC	Glutamate-cysteine ligase catalytic subunit. (637 aa)
	PSMD12	Proteasome 26S subunit, non-ATPase 12. (456 aa)
	PSMB10	Proteasome subunit beta. (273 aa)
	ENSCATP00000017689	6PGD domain-containing protein. (399 aa)
	LOC105579883	Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (238 aa)
	UBA52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
	ENSCATP00000016481	AAA domain-containing protein. (370 aa)
	ENSCATP00000016334	Uncharacterized protein. (338 aa)
	ME1	Malic enzyme. (572 aa)
	MUL1	Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
	ENSCATP00000015253	AAA domain-containing protein. (373 aa)
	PSMB3	Proteasome subunit beta. (205 aa)
	ENSCATP00000014541	Prot_ATP_ID_OB domain-containing protein. (172 aa)
	TRIM21	Tripartite motif containing 21. (475 aa)
	PSMC6	AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa)
	PSMD4	Proteasome 26S subunit, non-ATPase 4. (363 aa)
	KEAP1	Kelch like ECH associated protein 1. (624 aa)
	ATF4	Activating transcription factor 4. (351 aa)
	PSMD6	Proteasome 26S subunit, non-ATPase 6. (442 aa)
	ENSCATP00000011971	Uncharacterized protein. (191 aa)
	ENSCATP00000011808	Ubiquitin-like domain-containing protein. (130 aa)
	ENSCATP00000011745	AAA domain-containing protein. (410 aa)
	GSR	Glutathione-disulfide reductase. (444 aa)
	ENSCATP00000010748	Thioredoxin domain-containing protein. (193 aa)
	ENSCATP00000010732	CSN8_PSD8_EIF3K domain-containing protein. (249 aa)
	PSMA2	Proteasome subunit alpha type. (234 aa)
	SLC7A11	Solute carrier family 7 member 11. (519 aa)
	NQO1	NAD(P)H quinone dehydrogenase 1. (274 aa)
	SESN1	Sestrin 1. (551 aa)
	VCP	Valosin containing protein; Belongs to the AAA ATPase family. (806 aa)
	PSMB8	Proteasome subunit beta. (276 aa)
	PSMD7	Proteasome 26S subunit, non-ATPase 7. (324 aa)
	NOTCH1	Notch receptor 1. (2547 aa)
	LOC105600325	Uncharacterized protein. (179 aa)
	CSNK2A2	Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (350 aa)
	PSMB5	Proteasome subunit beta. (263 aa)
	LOC105579396	Ubiquitin-like domain-containing protein. (156 aa)
	BACH1	BTB domain and CNC homolog 1. (736 aa)
	PSMC3	AAA domain-containing protein; Belongs to the AAA ATPase family. (439 aa)
	UBXN7	UBX domain-containing protein 7. (491 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	MTFP1	Uncharacterized protein. (161 aa)
	KLHL17	Kelch like family member 17. (641 aa)
	LOC105576738	Ubiquitin-like domain-containing protein. (134 aa)
	LOC105574918	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (806 aa)
	PGD	6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (483 aa)
	SESN2	Sestrin 2. (480 aa)
	ENSCATP00000004934	ATPase_AAA_core domain-containing protein; Belongs to the AAA ATPase family. (177 aa)
	PSMF1	Proteasome inhibitor subunit 1. (271 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	PSMA1	Proteasome subunit alpha type. (269 aa)
	ENSCATP00000003644	ANK_REP_REGION domain-containing protein. (116 aa)
	ENSCATP00000003572	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (433 aa)
	PSMA7	Proteasome subunit alpha type. (248 aa)
	AMER1	APC membrane recruitment protein 1. (1185 aa)
	PSMB11	Proteasome subunit beta. (300 aa)
	G6PD	Glucose-6-phosphate dehydrogenase. (543 aa)
	KLHL18	Kelch like family member 18. (579 aa)
	DPP3	Dipeptidyl peptidase 3; Belongs to the peptidase M49 family. (757 aa)
	ENSCATP00000000117	Uncharacterized protein. (93 aa)
	PSMD5	Proteasome 26S subunit, non-ATPase 5. (508 aa)
	ENSCATP00000043644	Ubiquitin-like domain-containing protein. (120 aa)
	BRCA1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1871 aa)
	MAFG	MAF bZIP transcription factor G. (162 aa)
	HMOX1	Heme oxygenase 1. (311 aa)
	PSME2	Proteasome activator subunit 2. (239 aa)
	GCLM	Glutamate-cysteine ligase modifier subunit. (274 aa)
	PSME4	Proteasome activator subunit 4. (1792 aa)

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT2	ENSCATP00000006645	ENSCATP00000032050	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.972
AKT1	AKT3	ENSCATP00000006645	ENSCATP00000019579	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.920
AKT1	ATF4	ENSCATP00000006645	ENSCATP00000012524	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Activating transcription factor 4.	0.797
AKT1	BACH1	ENSCATP00000006645	ENSCATP00000006831	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BTB domain and CNC homolog 1.	0.461
AKT1	BACH2	ENSCATP00000006645	ENSCATP00000027672	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BTB domain and CNC homolog 2.	0.461
AKT1	BRCA1	ENSCATP00000006645	ENSCATP00000044041	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.969
AKT1	CDKN1A	ENSCATP00000006645	ENSCATP00000004883	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin dependent kinase inhibitor 1A.	0.973
AKT1	CREBBP	ENSCATP00000006645	ENSCATP00000033055	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	CREB binding protein.	0.457
AKT1	CUL1	ENSCATP00000006645	ENSCATP00000036515	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cullin 1; Belongs to the cullin family.	0.411
AKT1	EP300	ENSCATP00000006645	ENSCATP00000042119	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	E1A binding protein p300.	0.789
AKT1	GSK3B	ENSCATP00000006645	ENSCATP00000022071	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.980
AKT1	MYC	ENSCATP00000006645	ENSCATP00000029028	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.521
AKT1	NFE2L1	ENSCATP00000006645	ENSCATP00000035863	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nuclear factor, erythroid 2 like 1.	0.549
AKT1	NFE2L2	ENSCATP00000006645	ENSCATP00000026874	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nuclear factor, erythroid 2 like 2.	0.702
AKT1	NFE2L3	ENSCATP00000006645	ENSCATP00000035076	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nuclear factor, erythroid 2 like 3.	0.549
AKT1	NOTCH1	ENSCATP00000006645	ENSCATP00000007947	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Notch receptor 1.	0.577
AKT1	RBX1	ENSCATP00000006645	ENSCATP00000025654	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Ring-box 1.	0.408
AKT1	SKP2	ENSCATP00000006645	ENSCATP00000021122	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	S-phase kinase associated protein 2.	0.678
AKT2	AKT1	ENSCATP00000032050	ENSCATP00000006645	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.972
AKT2	AKT3	ENSCATP00000032050	ENSCATP00000019579	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.915