(19 nodes) Guanine nucleotide exchange factor for Ras-like GTPases network (Cercocebus atys)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RAPGEF2	Rap guanine nucleotide exchange factor 2. (1591 aa)
	RAPGEF4	Rap guanine nucleotide exchange factor 4. (1011 aa)
	RASGEF1B	RasGEF domain family member 1B. (560 aa)
	RGL2	Ral guanine nucleotide dissociation stimulator like 2. (777 aa)
	KNDC1	Kinase non-catalytic C-lobe domain containing 1. (1748 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1327 aa)
	RASGRP2	RAS guanyl releasing protein 2. (610 aa)
	RAPGEF5	Rap guanine nucleotide exchange factor 5. (730 aa)
	RGL1	Ral guanine nucleotide dissociation stimulator like 1. (803 aa)
	RASGRF2	Ras protein specific guanine nucleotide releasing factor 2. (1237 aa)
	RAPGEF3	Rap guanine nucleotide exchange factor 3. (925 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor 1. (1303 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
	RALGDS	Uncharacterized protein. (912 aa)
	RASGRP1	RAS guanyl releasing protein 1. (837 aa)
	RASGEF1A	RasGEF domain family member 1A. (489 aa)
	RASGRP3	RAS guanyl releasing protein 3. (689 aa)
	RAPGEF6	Uncharacterized protein. (1609 aa)
	RASGRF1	Ras protein specific guanine nucleotide releasing factor 1. (1273 aa)

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RAPGEF2	RAPGEF6	ENSCATP00000038330	ENSCATP00000035171	Rap guanine nucleotide exchange factor 2.	Uncharacterized protein.	0.945
RAPGEF2	RASGEF1A	ENSCATP00000038330	ENSCATP00000020729	Rap guanine nucleotide exchange factor 2.	RasGEF domain family member 1A.	0.467
RAPGEF2	RASGEF1B	ENSCATP00000038330	ENSCATP00000015659	Rap guanine nucleotide exchange factor 2.	RasGEF domain family member 1B.	0.469
RAPGEF3	RAPGEF4	ENSCATP00000011459	ENSCATP00000019651	Rap guanine nucleotide exchange factor 3.	Rap guanine nucleotide exchange factor 4.	0.895
RAPGEF4	RAPGEF3	ENSCATP00000019651	ENSCATP00000011459	Rap guanine nucleotide exchange factor 4.	Rap guanine nucleotide exchange factor 3.	0.895
RAPGEF6	RAPGEF2	ENSCATP00000035171	ENSCATP00000038330	Uncharacterized protein.	Rap guanine nucleotide exchange factor 2.	0.945
RASGEF1A	RAPGEF2	ENSCATP00000020729	ENSCATP00000038330	RasGEF domain family member 1A.	Rap guanine nucleotide exchange factor 2.	0.467
RASGEF1A	SOS1	ENSCATP00000020729	ENSCATP00000004020	RasGEF domain family member 1A.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.424
RASGEF1B	RAPGEF2	ENSCATP00000015659	ENSCATP00000038330	RasGEF domain family member 1B.	Rap guanine nucleotide exchange factor 2.	0.469
RASGRF1	RASGRF2	ENSCATP00000038616	ENSCATP00000012877	Ras protein specific guanine nucleotide releasing factor 1.	Ras protein specific guanine nucleotide releasing factor 2.	0.902
RASGRF1	SOS1	ENSCATP00000038616	ENSCATP00000004020	Ras protein specific guanine nucleotide releasing factor 1.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.435
RASGRF1	SOS2	ENSCATP00000038616	ENSCATP00000039379	Ras protein specific guanine nucleotide releasing factor 1.	SOS Ras/Rho guanine nucleotide exchange factor 2.	0.436
RASGRF2	RASGRF1	ENSCATP00000012877	ENSCATP00000038616	Ras protein specific guanine nucleotide releasing factor 2.	Ras protein specific guanine nucleotide releasing factor 1.	0.902
RASGRF2	SOS1	ENSCATP00000012877	ENSCATP00000004020	Ras protein specific guanine nucleotide releasing factor 2.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.421
RASGRF2	SOS2	ENSCATP00000012877	ENSCATP00000039379	Ras protein specific guanine nucleotide releasing factor 2.	SOS Ras/Rho guanine nucleotide exchange factor 2.	0.436
RASGRP1	RASGRP2	ENSCATP00000043175	ENSCATP00000040131	RAS guanyl releasing protein 1.	RAS guanyl releasing protein 2.	0.896
RASGRP1	RASGRP3	ENSCATP00000043175	ENSCATP00000025908	RAS guanyl releasing protein 1.	RAS guanyl releasing protein 3.	0.756
RASGRP1	SOS1	ENSCATP00000043175	ENSCATP00000004020	RAS guanyl releasing protein 1.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.900
RASGRP1	SOS2	ENSCATP00000043175	ENSCATP00000039379	RAS guanyl releasing protein 1.	SOS Ras/Rho guanine nucleotide exchange factor 2.	0.900
RASGRP2	RASGRP1	ENSCATP00000040131	ENSCATP00000043175	RAS guanyl releasing protein 2.	RAS guanyl releasing protein 1.	0.896