STRINGSTRING
ENSCATP00000000152 ENSCATP00000000152 ENSCATP00000000560 ENSCATP00000000560 PDGFA PDGFA FGF2 FGF2 CEP152 CEP152 TPTE2 TPTE2 SOS1 SOS1 SRC SRC BAX BAX ERAS ERAS GAB1 GAB1 PDGFRA PDGFRA AKT1 AKT1 ENSCATP00000006855 ENSCATP00000006855 ENSCATP00000007407 ENSCATP00000007407 ENSCATP00000007662 ENSCATP00000007662 ERBB2 ERBB2 JAK2 JAK2 PRKCB PRKCB KDR KDR IGF1R IGF1R RPS6KB1 RPS6KB1 ENSCATP00000010452 ENSCATP00000010452 ERBB3 ERBB3 MAPK3 MAPK3 KRAS KRAS VEGFA VEGFA AXL AXL ARAF ARAF PTEN PTEN MAP2K2 MAP2K2 RPS6KB2 RPS6KB2 PRKCA PRKCA HRAS HRAS MAPK1 MAPK1 PDGFD PDGFD STAT3 STAT3 ENSCATP00000017894 ENSCATP00000017894 BAD BAD LOC105572981 LOC105572981 AKT3 AKT3 LOC105575034 LOC105575034 FGFR3 FGFR3 PLCG2 PLCG2 TBCA TBCA PRKCG PRKCG BRAF BRAF BCL2L1 BCL2L1 GAS6 GAS6 GSK3B GSK3B PLCG1 PLCG1 RPS6 RPS6 EIF4E2 EIF4E2 PIK3R2 PIK3R2 PIK3CB PIK3CB LOC105585293 LOC105585293 RAF1 RAF1 PDGFC PDGFC EIF4E1B EIF4E1B PIK3CA PIK3CA SHC1 SHC1 CSDE1 CSDE1 PIK3R3 PIK3R3 EIF4E EIF4E PIK3R1 PIK3R1 FGFR2 FGFR2 NRG1 NRG1 MET MET IGF1 IGF1 MAP2K1 MAP2K1 SHC3 SHC3 GRB2 GRB2 IL6R IL6R BCL2 BCL2 EIF4EBP1 EIF4EBP1 NRG2 NRG2 PDGFRB PDGFRB PPP1R14B PPP1R14B ENSCATP00000030673 ENSCATP00000030673 ENSCATP00000031901 ENSCATP00000031901 AKT2 AKT2 FOXO3 FOXO3 EGFR EGFR SHC4 SHC4 HGF HGF NF1 NF1 MTOR MTOR NRAS NRAS JAK1 JAK1 IL6 IL6 EGF EGF ENSCATP00000037667 ENSCATP00000037667 PIK3CD PIK3CD SOS2 SOS2 PDGFB PDGFB BCL2L11 BCL2L11 TGFA TGFA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCATP00000000152Uncharacterized protein. (64 aa)
ENSCATP00000000560C2 tensin-type domain-containing protein. (165 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
CEP152Centrosomal protein 152. (1706 aa)
TPTE2Uncharacterized protein. (550 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
SRCTyrosine-protein kinase. (644 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
ERASES cell expressed Ras. (233 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1024 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ENSCATP00000006855Uncharacterized protein. (519 aa)
ENSCATP00000007407PID domain-containing protein. (502 aa)
ENSCATP00000007662Tubulin-specific chaperone A; Belongs to the TBCA family. (108 aa)
ERBB2Receptor protein-tyrosine kinase. (1399 aa)
JAK2Tyrosine-protein kinase. (1137 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
IGF1RTyrosine-protein kinase receptor. (1366 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ENSCATP00000010452Uncharacterized protein. (596 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1349 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (409 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (497 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
STAT3Signal transducer and activator of transcription. (777 aa)
ENSCATP0000001789440S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (204 aa)
BADBCL2 associated agonist of cell death. (167 aa)
LOC105572981Uncharacterized protein. (132 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC10557503440S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (243 aa)
FGFR3Fibroblast growth factor receptor. (809 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1236 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (131 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (762 aa)
BCL2L1BCL2 like 1. (233 aa)
GAS6Growth arrest specific 6. (683 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (440 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (249 aa)
PIK3R2Uncharacterized protein. (624 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
LOC105585293Uncharacterized protein. (290 aa)
RAF1Uncharacterized protein. (668 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (244 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
SHC1SHC adaptor protein 1. (584 aa)
CSDE1Cold shock domain containing E1. (844 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
EIF4EEukaryotic translation initiation factor 4E. (247 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
NRG1Neuregulin 1. (713 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1404 aa)
IGF1Insulin like growth factor 1. (208 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (344 aa)
SHC3SHC adaptor protein 3. (598 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
IL6RInterleukin 6 receptor. (452 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
NRG2Neuregulin 2. (851 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
PPP1R14BUncharacterized protein. (207 aa)
ENSCATP00000030673Uncharacterized protein. (652 aa)
ENSCATP0000003190140S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (224 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
FOXO3Forkhead box O3. (672 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
SHC4SHC adaptor protein 4. (630 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (788 aa)
NF1Neurofibromin 1. (2839 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (214 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa)
ENSCATP00000037667Protein kinase domain-containing protein. (365 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1327 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
TGFATransforming growth factor alpha. (166 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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