STRINGSTRING
GPER1 GPER1 MDM2 MDM2 FOS FOS HBEGF HBEGF PRKACA PRKACA BCL2 BCL2 GRB2 GRB2 MAPK10 MAPK10 SHC3 SHC3 NOTCH3 NOTCH3 IGF1 IGF1 SOS2 SOS2 PRKACB PRKACB MAPK14 MAPK14 ENSCATP00000038535 ENSCATP00000038535 PIK3CD PIK3CD NOTCH2 NOTCH2 ENSCATP00000037667 ENSCATP00000037667 NRAS NRAS MTOR MTOR JAG1 JAG1 CCND1 CCND1 SHC4 SHC4 E2F3 E2F3 EGFR EGFR CDKN1B CDKN1B E2F1 E2F1 AKT2 AKT2 TP53 TP53 GNAS GNAS DLL1 DLL1 NOTCH4 NOTCH4 ENSCATP00000030673 ENSCATP00000030673 PPP1R14B PPP1R14B MAP2K1 MAP2K1 DLL4 DLL4 PIK3R1 PIK3R1 PIK3R3 PIK3R3 CSDE1 CSDE1 SHC1 SHC1 PIK3CA PIK3CA LOC105573227 LOC105573227 ADCY5 ADCY5 ESR2 ESR2 ENSCATP00000025923 ENSCATP00000025923 NCOA3 NCOA3 RAF1 RAF1 LOC105585293 LOC105585293 PIK3CB PIK3CB PIK3R2 PIK3R2 CARM1 CARM1 BRAF BRAF ADCY8 ADCY8 MAPK12 MAPK12 ADCY2 ADCY2 MAPK9 MAPK9 PTRHD1 PTRHD1 AKT3 AKT3 LOC105572981 LOC105572981 BAD BAD NCOR1 NCOR1 MAPK1 MAPK1 MED1 MED1 ADCY6 ADCY6 CCDC170 CCDC170 HRAS HRAS RPS6KB2 RPS6KB2 MAP2K2 MAP2K2 ADCY9 ADCY9 ENSCATP00000012945 ENSCATP00000012945 ARAF ARAF DLL3 DLL3 ESR1 ESR1 ABCB11 ABCB11 KRAS KRAS E2F2 E2F2 MAPK3 MAPK3 MMP9 MMP9 BIK BIK ENSCATP00000010452 ENSCATP00000010452 RPS6KB1 RPS6KB1 MAPK11 MAPK11 CDKN2C CDKN2C IGF1R IGF1R ERBB2 ERBB2 NOTCH1 NOTCH1 ADCY7 ADCY7 ENSCATP00000007407 ENSCATP00000007407 ENSCATP00000006855 ENSCATP00000006855 MAPK13 MAPK13 AKT1 AKT1 JAG2 JAG2 RB1 RB1 CDK4 CDK4 SP1 SP1 PTK2 PTK2 CDKN1A CDKN1A ERAS ERAS BAX BAX SRC SRC SOS1 SOS1 MMP2 MMP2 CEP152 CEP152 LOC105585318 LOC105585318 MAPK8 MAPK8 CDKN2A CDKN2A GPSM3 GPSM3 LOC105572143 LOC105572143 ADCY3 ADCY3 ADCY4 ADCY4 ADCY1 ADCY1 ENSCATP00000000152 ENSCATP00000000152
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
SHC3SHC adaptor protein 3. (598 aa)
NOTCH3Notch receptor 3. (2321 aa)
IGF1Insulin like growth factor 1. (208 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1327 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ENSCATP00000038535E2F_CC-MB domain-containing protein. (193 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NOTCH2Notch receptor 2. (2610 aa)
ENSCATP00000037667Protein kinase domain-containing protein. (365 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
SHC4SHC adaptor protein 4. (630 aa)
E2F3E2F transcription factor 3. (467 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
E2F1E2F transcription factor 1. (437 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
GNASGNAS complex locus. (1028 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
NOTCH4Notch receptor 4. (2000 aa)
ENSCATP00000030673Uncharacterized protein. (652 aa)
PPP1R14BUncharacterized protein. (207 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (344 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (713 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
CSDE1Cold shock domain containing E1. (844 aa)
SHC1SHC adaptor protein 1. (584 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
LOC105573227Uncharacterized protein; Belongs to the cytochrome P450 family. (508 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
ESR2Estrogen receptor 2. (530 aa)
ENSCATP00000025923Uncharacterized protein. (618 aa)
NCOA3Nuclear receptor coactivator. (1428 aa)
RAF1Uncharacterized protein. (668 aa)
LOC105585293Uncharacterized protein. (290 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
PIK3R2Uncharacterized protein. (624 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (661 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (762 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (139 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC105572981Uncharacterized protein. (132 aa)
BADBCL2 associated agonist of cell death. (167 aa)
NCOR1Nuclear receptor corepressor 1. (2442 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1570 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
CCDC170Coiled-coil domain containing 170. (709 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (497 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1372 aa)
ENSCATP00000012945Protein kinase domain-containing protein. (101 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
DLL3Delta like canonical Notch ligand 3. (618 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
ABCB11ATP binding cassette subfamily B member 11. (1317 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
E2F2E2F transcription factor 2. (437 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
BIKBCL2 interacting killer. (156 aa)
ENSCATP00000010452Uncharacterized protein. (596 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
IGF1RTyrosine-protein kinase receptor. (1366 aa)
ERBB2Receptor protein-tyrosine kinase. (1399 aa)
NOTCH1Notch receptor 1. (2547 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1114 aa)
ENSCATP00000007407PID domain-containing protein. (502 aa)
ENSCATP00000006855Uncharacterized protein. (519 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1162 aa)
RB1RB transcriptional corepressor 1. (926 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
SP1Sp1 transcription factor. (786 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1068 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ERASES cell expressed Ras. (233 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
SRCTyrosine-protein kinase. (644 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
CEP152Centrosomal protein 152. (1706 aa)
LOC105585318Uncharacterized protein. (246 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (159 aa)
GPSM3G protein signaling modulator 3. (160 aa)
LOC105572143Uncharacterized protein; Belongs to the cytochrome P450 family. (501 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1115 aa)
ENSCATP00000000152Uncharacterized protein. (64 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.