STRINGSTRING
ERBB2 ERBB2 MGST3 MGST3 BIRC3 BIRC3 GSTA4 GSTA4 ABCC2 ABCC2 CASP3 CASP3 TOP2B TOP2B XIAP XIAP MAPK3 MAPK3 TOP2A TOP2A ATP7B ATP7B ENSCATP00000013584 ENSCATP00000013584 ENSCATP00000015662 ENSCATP00000015662 MAPK1 MAPK1 BIRC5 BIRC5 ENSCATP00000017016 ENSCATP00000017016 BID BID GSTP1 GSTP1 PDPK1 PDPK1 BAD BAD GSTA2 GSTA2 LOC105572981 LOC105572981 AKT3 AKT3 MSH3 MSH3 GSTO2 GSTO2 FASLG FASLG BCL2L1 BCL2L1 ENSCATP00000023486 ENSCATP00000023486 PIK3R2 PIK3R2 PIK3CB PIK3CB FADD FADD ENSCATP00000024396 ENSCATP00000024396 ENSCATP00000024481 ENSCATP00000024481 GSTT2B GSTT2B PIK3CA PIK3CA CASP8 CASP8 PIK3R3 PIK3R3 GSTT4 GSTT4 PIK3R1 PIK3R1 PPP1R14B PPP1R14B GSTM1 GSTM1 BAK1 BAK1 ENSCATP00000031483 ENSCATP00000031483 TP53 TP53 AKT2 AKT2 ENSCATP00000032552 ENSCATP00000032552 BIRC2 BIRC2 ATM ATM MGST1 MGST1 ENSCATP00000035097 ENSCATP00000035097 SLC31A1 SLC31A1 MLH1 MLH1 MSH2 MSH2 GSTM3 GSTM3 POLH POLH PMAIP1 PMAIP1 PIK3CD PIK3CD ENSCATP00000038453 ENSCATP00000038453 XPA XPA FAS FAS APAF1 APAF1 LOC105571593 LOC105571593 GSTM2 GSTM2 ENSCATP00000041581 ENSCATP00000041581 BCL2 BCL2 BBC3 BBC3 BRCA1 BRCA1 MGST2 MGST2 MDM2 MDM2 LOC105589984 LOC105589984 AKT1 AKT1 LOC105588083 LOC105588083 GSTO1 GSTO1 MAP3K5 MAP3K5 CASP9 CASP9 ENSCATP00000005174 ENSCATP00000005174 CDKN1A CDKN1A ERCC1 ERCC1 BAX BAX ATP7A ATP7A ENSCATP00000004066 ENSCATP00000004066 C7orf31 C7orf31 LOC105599377 LOC105599377 CDKN2A CDKN2A ENSCATP00000002218 ENSCATP00000002218 ENSCATP00000001452 ENSCATP00000001452 LOC105595720 LOC105595720 ENSCATP00000000152 ENSCATP00000000152
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERBB2Receptor protein-tyrosine kinase. (1399 aa)
MGST3Microsomal glutathione S-transferase 3. (166 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
GSTA4Glutathione S-transferase alpha 4. (222 aa)
ABCC2ATP binding cassette subfamily C member 2. (1545 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1626 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1530 aa)
ATP7BATPase copper transporting beta. (1468 aa)
ENSCATP00000013584DNA_pol_B domain-containing protein. (383 aa)
ENSCATP00000015662Uncharacterized protein. (175 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
BIRC5Uncharacterized protein. (147 aa)
ENSCATP00000017016Uncharacterized protein; Belongs to the GST superfamily. (202 aa)
BIDBH3 interacting domain death agonist. (244 aa)
GSTP1Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (534 aa)
BADBCL2 associated agonist of cell death. (167 aa)
GSTA2Glutathione S-transferase alpha 2; Belongs to the GST superfamily. (222 aa)
LOC105572981Uncharacterized protein. (132 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1135 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (243 aa)
FASLGTumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa)
BCL2L1BCL2 like 1. (233 aa)
ENSCATP00000023486PWWP domain-containing protein. (150 aa)
PIK3R2Uncharacterized protein. (624 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
ENSCATP00000024396DNA_MISMATCH_REPAIR_2 domain-containing protein. (311 aa)
ENSCATP00000024481Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (95 aa)
GSTT2BUncharacterized protein; Belongs to the GST superfamily. (250 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (515 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
GSTT4Glutathione S-transferase theta 4; Belongs to the GST superfamily. (241 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PPP1R14BUncharacterized protein. (207 aa)
GSTM1Glutathione S-transferase mu 1; Belongs to the GST superfamily. (236 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
ENSCATP00000031483Uncharacterized protein. (171 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSCATP00000032552Cytochrome c domain-containing protein; Belongs to the cytochrome c family. (109 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3073 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
ENSCATP00000035097Uncharacterized protein. (213 aa)
SLC31A1Solute carrier family 31 member 1. (191 aa)
MLH1MutL homolog 1. (756 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (933 aa)
GSTM3Glutathione S-transferase. (225 aa)
POLHDNA polymerase eta. (712 aa)
PMAIP1Uncharacterized protein. (133 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ENSCATP00000038453Uncharacterized protein; Belongs to the peptidase C14A family. (262 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
FASTumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). (331 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
LOC105571593Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
GSTM2Glutathione S-transferase. (222 aa)
ENSCATP00000041581Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
BBC3BCL2 binding component 3. (261 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1871 aa)
MGST2Microsomal glutathione S-transferase 2. (147 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
LOC105589984Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC105588083Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
GSTO1Glutathione S-transferase omega 1; Belongs to the GST superfamily. (241 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (416 aa)
ENSCATP00000005174Uncharacterized protein. (224 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (323 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
ENSCATP00000004066Uncharacterized protein. (189 aa)
C7orf31Chromosome 7 open reading frame 31. (590 aa)
LOC105599377Uncharacterized protein. (266 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (159 aa)
ENSCATP00000002218Uncharacterized protein. (228 aa)
ENSCATP00000001452Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (98 aa)
LOC105595720Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSCATP00000000152Uncharacterized protein. (64 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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