STRINGSTRING
BRCA1 BRCA1 EME1 EME1 ENSCATP00000000450 ENSCATP00000000450 RBBP8 RBBP8 FICD FICD MEIOB MEIOB ABRAXAS2 ABRAXAS2 SEM1-2 SEM1-2 FAM9A FAM9A ENSCATP00000006241 ENSCATP00000006241 UNC93A UNC93A ENSCATP00000034029 ENSCATP00000034029 RAD51C RAD51C BLM BLM POLD2 POLD2 UIMC1 UIMC1 RAD52 RAD52 LOC105599742 LOC105599742 MRE11 MRE11 ENSCATP00000036401 ENSCATP00000036401 SYCP3 SYCP3 DDX52 DDX52 C12orf66 C12orf66 YJU2 YJU2 BRIP1 BRIP1 PALB2 PALB2 FAM9C FAM9C PTGDR2 PTGDR2 BARD1 BARD1 HELB HELB STN1 STN1 GTF3C6 GTF3C6 XRCC3 XRCC3 POLD3 POLD3 XRCC2 XRCC2 TOP3A TOP3A RPA2 RPA2 MPHOSPH9 MPHOSPH9 SLF1 SLF1 TOPBP1 TOPBP1 N4BP2 N4BP2 ATM ATM MUS81 MUS81 TM6SF2 TM6SF2 UNC93B1 UNC93B1 FAM9B FAM9B DMC1 DMC1 SLC4A1AP SLC4A1AP N4BP2L1 N4BP2L1 TOP3B TOP3B SSBP1 SSBP1 POLD4 POLD4 ABRAXAS1 ABRAXAS1 ENSCATP00000023349 ENSCATP00000023349 N4BP2L2 N4BP2L2 LOC105571810 LOC105571810 LURAP1 LURAP1 HELQ HELQ CNP CNP ENSCATP00000020770 ENSCATP00000020770 RAD51D RAD51D PRKRIP1 PRKRIP1 RAD51 RAD51 ENSCATP00000019568 ENSCATP00000019568 ENSCATP00000019356 ENSCATP00000019356 ENSCATP00000018692 ENSCATP00000018692 SAP130 SAP130 SUGP1 SUGP1 NBN NBN PWWP2A PWWP2A SASS6 SASS6 BABAM1 BABAM1 MCPH1 MCPH1 RAD51B RAD51B BRCA2 BRCA2 PITHD1 PITHD1 PPIL3 PPIL3 BABAM2 BABAM2 RECQL4 RECQL4 PIF1 PIF1 RAD54B RAD54B RAD54L RAD54L POLD1 POLD1 RECQL5 RECQL5 SUGP2 SUGP2 ENSCATP00000010284 ENSCATP00000010284 ENSCATP00000009666 ENSCATP00000009666 RPA3 RPA3 MCFD2 MCFD2 ENSCATP00000007798 ENSCATP00000007798 BRCC3 BRCC3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1871 aa)
EME1Essential meiotic structure-specific endonuclease 1. (584 aa)
ENSCATP00000000450Uncharacterized protein. (276 aa)
RBBP8RB binding protein 8, endonuclease. (905 aa)
FICDFIC domain containing. (460 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
ABRAXAS2Abraxas 2, BRISC complex subunit. (404 aa)
SEM1-2Uncharacterized protein. (89 aa)
FAM9AFamily with sequence similarity 9 member A. (286 aa)
ENSCATP00000006241Uncharacterized protein. (269 aa)
UNC93AUnc-93 homolog A. (457 aa)
ENSCATP00000034029Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (581 aa)
RAD51CRAD51 paralog C. (367 aa)
BLMBLM RecQ like helicase. (1416 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
UIMC1Ubiquitin interaction motif containing 1. (684 aa)
RAD52RAD52 homolog, DNA repair protein. (397 aa)
LOC105599742Zinc-hook domain-containing protein. (1192 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
ENSCATP00000036401Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (262 aa)
SYCP3Cor1 domain-containing protein. (236 aa)
DDX52DExD-box helicase 52. (599 aa)
C12orf66Chromosome 12 open reading frame 66. (468 aa)
YJU2YJU2 splicing factor homolog. (323 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1217 aa)
PALB2Partner and localizer of BRCA2. (1192 aa)
FAM9CFamily with sequence similarity 9 member C. (166 aa)
PTGDR2Prostaglandin D2 receptor 2; Belongs to the G-protein coupled receptor 1 family. (396 aa)
BARD1BRCA1 associated RING domain 1. (777 aa)
HELBDNA helicase B. (1087 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
GTF3C6General transcription factor IIIC subunit 6. (212 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (381 aa)
POLD3Uncharacterized protein. (466 aa)
XRCC2X-ray repair cross complementing 2. (280 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (994 aa)
RPA2Replication protein A2. (270 aa)
MPHOSPH9M-phase phosphoprotein 9. (1180 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1059 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1527 aa)
N4BP2NEDD4 binding protein 2. (1722 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3073 aa)
MUS81MUS81 structure-specific endonuclease subunit. (559 aa)
TM6SF2Transmembrane 6 superfamily member 2. (377 aa)
UNC93B1Unc-93 homolog B1, TLR signaling regulator. (597 aa)
FAM9BFamily with sequence similarity 9 member B. (226 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (319 aa)
SLC4A1APSolute carrier family 4 member 1 adaptor protein. (786 aa)
N4BP2L1NEDD4 binding protein 2 like 1. (246 aa)
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa)
SSBP1Single stranded DNA binding protein 1. (148 aa)
POLD4Uncharacterized protein. (107 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (412 aa)
ENSCATP00000023349Uncharacterized protein. (136 aa)
N4BP2L2NEDD4 binding protein 2 like 2. (745 aa)
LOC105571810Cor1 domain-containing protein. (221 aa)
LURAP1Leucine rich adaptor protein 1. (239 aa)
HELQHelicase, POLQ like. (1101 aa)
CNP2',3'-cyclic nucleotide 3' phosphodiesterase. (423 aa)
ENSCATP00000020770Uncharacterized protein. (94 aa)
RAD51DDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (346 aa)
PRKRIP1PRKR interacting protein 1. (185 aa)
RAD51RAD51 recombinase; Belongs to the RecA family. (309 aa)
ENSCATP00000019568G-patch domain-containing protein. (533 aa)
ENSCATP00000019356RPA_C domain-containing protein. (276 aa)
ENSCATP00000018692MPN domain-containing protein. (273 aa)
SAP130Sin3A associated protein 130. (1089 aa)
SUGP1SURP and G-patch domain containing 1. (645 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
PWWP2APWWP domain containing 2A. (755 aa)
SASS6SAS-6 centriolar assembly protein. (657 aa)
BABAM1BRISC and BRCA1 A complex member 1. (329 aa)
MCPH1Microcephalin 1. (891 aa)
RAD51BRAD51 paralog B. (425 aa)
BRCA2BRCA2 DNA repair associated. (3419 aa)
PITHD1PITH domain containing 1. (211 aa)
PPIL3Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (161 aa)
BABAM2BRISC and BRCA1 A complex member 2. (415 aa)
RECQL4RecQ like helicase 4. (1208 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (691 aa)
RAD54BUncharacterized protein. (908 aa)
RAD54LRAD54 like. (747 aa)
POLD1DNA polymerase. (1107 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (991 aa)
SUGP2SURP and G-patch domain containing 2. (1084 aa)
ENSCATP00000010284Uncharacterized protein. (164 aa)
ENSCATP00000009666Uncharacterized protein. (121 aa)
RPA3Replication protein A3. (121 aa)
MCFD2Multiple coagulation factor deficiency 2. (146 aa)
ENSCATP00000007798Uncharacterized protein. (258 aa)
BRCC3MPN domain-containing protein. (293 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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