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| | SGK1 | Non-specific serine/threonine protein kinase. (529 aa) |
| | SNAPIN | SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa) |
| | TSSK3 | Testis specific serine kinase 3. (268 aa) |
| | GRB2 | Growth factor receptor bound protein 2. (217 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | GABARAPL1 | GABA type A receptor associated protein like 1. (145 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (474 aa) |
| | KLF2 | Kruppel like factor 2. (355 aa) |
| | EP300 | E1A binding protein p300. (2411 aa) |
| | ENSCATP00000041990 | Uncharacterized protein. (114 aa) |
| | IGF1 | Insulin like growth factor 1. (208 aa) |
| | S1PR1 | Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa) |
| | PLK1 | Serine/threonine-protein kinase PLK. (603 aa) |
| | BCL2L11 | Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | PRKAG3 | Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa) |
| | CCNB1 | Cyclin B1; Belongs to the cyclin family. (433 aa) |
| | FBXO25 | F-box protein 25. (367 aa) |
| | ATG12 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa) |
| | PRKAG2 | Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa) |
| | MYO9B | Myosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2157 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1327 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | SLC35E3 | Solute carrier family 35 member E3. (313 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | SOD2 | Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (232 aa) |
| | ENSCATP00000037667 | Protein kinase domain-containing protein. (365 aa) |
| | PLK3 | Serine/threonine-protein kinase PLK. (673 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa) |
| | REM1 | GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (214 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa) |
| | GADD45G | Growth arrest and DNA damage inducible gamma. (159 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | HOMER1 | Homer scaffold protein 1. (358 aa) |
| | PRMT1 | Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | PRMT3 | Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (531 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (366 aa) |
| | GABARAPL2 | GABA type A receptor associated protein like 2. (117 aa) |
| | ENSCATP00000010452 | Uncharacterized protein. (596 aa) |
| | PRKAB1 | Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa) |
| | TMEM232 | Transmembrane protein 232. (655 aa) |
| | CDKN2D | Cyclin dependent kinase inhibitor 2D. (166 aa) |
| | ENSCATP00000011488 | Uncharacterized protein. (91 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa) |
| | PMEPA1 | Prostate transmembrane protein, androgen induced 1. (287 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | ENSCATP00000011714 | Uncharacterized protein. (288 aa) |
| | LDLRAD4 | Low density lipoprotein receptor class A domain containing 4. (259 aa) |
| | IRS1 | Insulin receptor substrate 1. (1241 aa) |
| | ENSCATP00000012291 | Uncharacterized protein; Belongs to the cyclin family. (349 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | SETD7 | Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. (366 aa) |
| | ARAF | A-Raf proto-oncogene, serine/threonine kinase. (606 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | USP7 | Uncharacterized protein; Belongs to the peptidase C19 family. (1093 aa) |
| | PLK2 | Serine/threonine-protein kinase PLK. (685 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | PLK5 | Polo like kinase 5. (336 aa) |
| | CCNG2 | Cyclin G2; Belongs to the cyclin family. (334 aa) |
| | STK4 | Serine/threonine kinase 4. (495 aa) |
| | RASGEF1B | RasGEF domain family member 1B. (560 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | STAT3 | Signal transducer and activator of transcription. (777 aa) |
| | FOXJ2 | Forkhead box J2. (574 aa) |
| | GEM | GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (534 aa) |
| | RAG1 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1065 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | FOXJ3 | Forkhead box J3. (623 aa) |
| | FOXO4 | Forkhead box O4. (505 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | RASGEF1A | RasGEF domain family member 1A. (489 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (367 aa) |
| | CAT | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa) |
| | SKP2 | S-phase kinase associated protein 2. (437 aa) |
| | BRAF | B-Raf proto-oncogene, serine/threonine kinase. (762 aa) |
| | FASLG | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa) |
| | RRAD | GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa) |
| | PRKAG1 | Protein kinase AMP-activated non-catalytic subunit gamma 1. (333 aa) |
| | RASL11B | RAS like family 11 member B. (248 aa) |
| | PIK3R2 | Uncharacterized protein. (624 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa) |
| | RNF6 | Ring finger protein 6. (701 aa) |
| | RAF1 | Uncharacterized protein. (668 aa) |
| | IL7R | Interleukin 7 receptor. (459 aa) |
| | CDKN2B | Cyclin dependent kinase inhibitor 2B. (138 aa) |
| | TSSK4 | Testis specific serine kinase 4. (338 aa) |
| | FBXO32 | F-box protein 32. (355 aa) |
| | PLK4 | Polo like kinase 4. (970 aa) |
| | IRS4 | Insulin receptor substrate 4. (1222 aa) |
| | HOMER2 | Homer scaffold protein 2. (356 aa) |
| | HOMER3 | WH1 domain-containing protein. (361 aa) |
| | CCND2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa) |
| | FOXO1 | Forkhead box O1. (655 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa) |
| | CSDE1 | Cold shock domain containing E1. (844 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase regulatory subunit 3. (461 aa) |
| | CCNB2 | Cyclin B2; Belongs to the cyclin family. (398 aa) |
| | SGK2 | Serum/glucocorticoid regulated kinase 2. (413 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | IRS2 | Insulin receptor substrate 2. (1338 aa) |
| | BCL6 | BCL6 transcription repressor. (706 aa) |
| | PCK2 | Phosphoenolpyruvate carboxykinase 2, mitochondrial. (645 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (344 aa) |
| | ENSCATP00000030673 | Uncharacterized protein. (652 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | FOXO3 | Forkhead box O3. (672 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3073 aa) |
| | GADD45B | Growth arrest and DNA damage inducible beta. (160 aa) |
| | CDKN1B | Cyclin dependent kinase inhibitor 1B. (198 aa) |
| | CREBBP | CREB binding protein. (2442 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1210 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (574 aa) |
| | G6PC3 | Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | SLC2A4 | Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (522 aa) |
| | SIRT1 | Sirtuin 1. (744 aa) |
| | PRKAA2 | Non-specific serine/threonine protein kinase. (552 aa) |
| | GADD45A | Growth arrest and DNA damage inducible alpha. (165 aa) |
| | ENSCATP00000000090 | Uncharacterized protein. (233 aa) |
| | PRKAB2 | Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa) |
| | ENSCATP00000000560 | C2 tensin-type domain-containing protein. (165 aa) |
| | TSSK6 | Testis specific serine kinase 6; Belongs to the protein kinase superfamily. (273 aa) |
| | G6PC | Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa) |
| | BCL6B | BCL6B transcription repressor. (474 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (429 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (384 aa) |
| | RBL2 | RB transcriptional corepressor like 2. (1139 aa) |
| | GABARAP | Uncharacterized protein. (117 aa) |
| | PRMT8 | Protein arginine methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (394 aa) |
| | NLK | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa) |
| | REM2 | GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (340 aa) |
| | AGAP2 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1192 aa) |
| | GRM1 | Glutamate metabotropic receptor 1. (1195 aa) |
| | TPTE2 | Uncharacterized protein. (550 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa) |
| | ERAS | ES cell expressed Ras. (233 aa) |
| | SGK3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (438 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (164 aa) |
| | ENSCATP00000004979 | Protein kinase domain-containing protein. (393 aa) |
| | FOXG1 | Forkhead box G1. (489 aa) |
| | S1PR4 | Sphingosine-1-phosphate receptor 4. (384 aa) |
| | RAG2 | Recombination activating 2. (532 aa) |
| | TSSK2 | Testis specific serine kinase 2; Belongs to the protein kinase superfamily. (362 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (365 aa) |
| | PCK1 | Phosphoenolpyruvate carboxykinase 1. (622 aa) |
| | CNTD2 | Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (304 aa) |
| | GRAP | GRB2 related adaptor protein. (217 aa) |
| | INSR | Tyrosine-protein kinase receptor. (1339 aa) |
| | CCNB3 | Cyclin B3; Belongs to the cyclin family. (1357 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | IGF1R | Tyrosine-protein kinase receptor. (1366 aa) |
| | FOXO6 | Forkhead box O6. (626 aa) |
| | SUCO | SUN domain containing ossification factor. (1374 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa) |
| | TNFSF10 | Tumor necrosis factor ligand superfamily member. (281 aa) |
| | BNIP3 | BCL2 interacting protein 3. (194 aa) |
| | MYO9A | Myosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2626 aa) |
| | INS | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa) |
