STRINGSTRING
GRM2 GRM2 KRAS KRAS RUFY4 RUFY4 ENSCATP00000012908 ENSCATP00000012908 ADCY9 ADCY9 PIP5K1B PIP5K1B PIK3R1 PIK3R1 SRMS SRMS TSC2 TSC2 RHEBL1 RHEBL1 MAP2K1 MAP2K1 F2 F2 AGPAT5 AGPAT5 CYTH1 CYTH1 DGKG DGKG RGL4 RGL4 DNM3 DNM3 DNM2 DNM2 DGKQ DGKQ PLD2 PLD2 AVP AVP GNAS GNAS AKT2 AKT2 PTK6 PTK6 RALB RALB CYTH4 CYTH4 GRM7 GRM7 ENSCATP00000032953 ENSCATP00000032953 GRM5 GRM5 EGFR EGFR SPHK1 SPHK1 SHC4 SHC4 PIK3CG PIK3CG AGPAT2 AGPAT2 DGKA DGKA SPHK2 SPHK2 PLA2G4D PLA2G4D MTOR MTOR DGKD DGKD NRAS NRAS EGF EGF ENSCATP00000037667 ENSCATP00000037667 PIK3CD PIK3CD PIK3R5 PIK3R5 SOS2 SOS2 GRM6 GRM6 AVPR1A AVPR1A PDGFB PDGFB AGTR1 AGTR1 AVPR1B AVPR1B LPAR4 LPAR4 RRAS2 RRAS2 PLPP2 PLPP2 SHC3 SHC3 MRAS MRAS GNA12 GNA12 GRB2 GRB2 ENSCATP00000043907 ENSCATP00000043907 INS INS ENSCATP00000044421 ENSCATP00000044421 CXCL8 CXCL8 PDGFRB PDGFRB PLCB1 PLCB1 RHOC RHOC MAP2K2 MAP2K2 GAB4 GAB4 PRKCA PRKCA HRAS HRAS ENSCATP00000015134 ENSCATP00000015134 ADCY6 ADCY6 ENSCATP00000015421 ENSCATP00000015421 DGKK DGKK MAPK1 MAPK1 PLCB3 PLCB3 LPAR3 LPAR3 PDGFD PDGFD TSC1 TSC1 DGKI DGKI RGL4-2 RGL4-2 PLA2G4B PLA2G4B PTK2B PTK2B DGKH DGKH GNA13 GNA13 ENSCATP00000009482 ENSCATP00000009482 RALA RALA AGPAT3 AGPAT3 CYTH2 CYTH2 PLA2G4A PLA2G4A GRM4 GRM4 INSR INSR ADCY7 ADCY7 ENSCATP00000007407 ENSCATP00000007407 ENSCATP00000007240 ENSCATP00000007240 ENSCATP00000006855 ENSCATP00000006855 ENSCATP00000006715 ENSCATP00000006715 KITLG KITLG AKT1 AKT1 PDGFRA PDGFRA GAB1 GAB1 ENSCATP00000005869 ENSCATP00000005869 LOC105574050 LOC105574050 RHOA RHOA GPR55 GPR55 ENSCATP00000005024 ENSCATP00000005024 ERAS ERAS CYTH3 CYTH3 LPAR6 LPAR6 SOS1 SOS1 GRM1 GRM1 CEP152 CEP152 PLA2G4C PLA2G4C LOC105575634 LOC105575634 ENSCATP00000003016 ENSCATP00000003016 AGPAT4 AGPAT4 LOC105585318 LOC105585318 RALGDS RALGDS ARF6 ARF6 SYK SYK ENSCATP00000001613 ENSCATP00000001613 RRAS RRAS ADCY3 ADCY3 LPAR5 LPAR5 DGKB DGKB ADCY4 ADCY4 KIT KIT LOC105574081 LOC105574081 PLPP3 PLPP3 F2R F2R ADCY1 ADCY1 PDGFA PDGFA FCER1G FCER1G LPAR1 LPAR1 LOC105575857 LOC105575857 PLCG1 PLCG1 ENSCATP00000022023 ENSCATP00000022023 ENSCATP00000021227 ENSCATP00000021227 ADCY8 ADCY8 GAB2 GAB2 ARF1 ARF1 PIP5K1C PIP5K1C ADCY2 ADCY2 PLCG2 PLCG2 FCER1A FCER1A PLD1 PLD1 LOC105577130 LOC105577130 PIK3R6 PIK3R6 PTRHD1 PTRHD1 PTPN11 PTPN11 RAPGEF4 RAPGEF4 JMJD7 JMJD7 AKT3 AKT3 PIP5K1A PIP5K1A GRM8 GRM8 PLPP1 PLPP1 ENSCATP00000010452 ENSCATP00000010452 MS4A2 MS4A2 PLA2G4E PLA2G4E LOC105575920 LOC105575920 RAPGEF3 RAPGEF3 MAPK3 MAPK3 PLCB2 PLCB2 PTGFR PTGFR DGKZ DGKZ PIK3R3 PIK3R3 CSDE1 CSDE1 SHC1 SHC1 PIK3CA PIK3CA RHEB RHEB AGT AGT PLCB4 PLCB4 ADCY5 ADCY5 AGPAT1 AGPAT1 PLA2G4F PLA2G4F AVPR2 AVPR2 LPAR2 LPAR2 DGKE DGKE PDGFC PDGFC RAF1 RAF1 ZNF408 ZNF408 LOC105585293 LOC105585293 PIK3CB PIK3CB GRM3 GRM3 PIK3R2 PIK3R2 FYN FYN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GRM2Glutamate metabotropic receptor 2. (872 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
RUFY4RUN and FYVE domain containing 4. (602 aa)
ENSCATP00000012908Ig-like domain-containing protein. (144 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1372 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (540 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
SRMSTyrosine-protein kinase. (492 aa)
TSC2TSC complex subunit 2. (1807 aa)
RHEBL1RHEB like 1. (187 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (344 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
AGPAT51-acylglycerol-3-phosphate O-acyltransferase 5. (364 aa)
CYTH1Cytohesin 1. (411 aa)
DGKGDiacylglycerol kinase. (791 aa)
RGL4Ral guanine nucleotide dissociation stimulator like 4. (532 aa)
DNM3Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (869 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
DGKQDiacylglycerol kinase. (955 aa)
PLD2Phospholipase. (933 aa)
AVPArginine vasopressin. (164 aa)
GNASGNAS complex locus. (1028 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PTK6Tyrosine-protein kinase. (507 aa)
RALBRAS like proto-oncogene B. (212 aa)
CYTH4Cytohesin 4. (394 aa)
GRM7Glutamate metabotropic receptor 7. (922 aa)
ENSCATP00000032953PIPK domain-containing protein. (487 aa)
GRM5Glutamate metabotropic receptor 5. (1212 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
SPHK1Sphingosine kinase 1. (470 aa)
SHC4SHC adaptor protein 4. (630 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
AGPAT21-acylglycerol-3-phosphate O-acyltransferase 2. (269 aa)
DGKADiacylglycerol kinase. (735 aa)
SPHK2Sphingosine kinase 2. (653 aa)
PLA2G4DPhospholipase A2. (817 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
DGKDDiacylglycerol kinase. (1216 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa)
ENSCATP00000037667Protein kinase domain-containing protein. (365 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (880 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1327 aa)
GRM6Glutamate metabotropic receptor 6. (877 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (421 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (424 aa)
LPAR4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa)
RRAS2RAS related 2. (204 aa)
PLPP2Phospholipid phosphatase 2. (303 aa)
SHC3SHC adaptor protein 3. (598 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
GNA12G protein subunit alpha 12. (381 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ENSCATP00000043907Uncharacterized protein. (193 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ENSCATP00000044421Uncharacterized protein. (441 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
RHOCRas homolog family member C. (193 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
GAB4GRB2 associated binding protein family member 4. (536 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ENSCATP00000015134Ig-like domain-containing protein. (173 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
ENSCATP00000015421Ig-like domain-containing protein. (140 aa)
DGKKDiacylglycerol kinase. (1281 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (353 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
TSC1TSC complex subunit 1. (1167 aa)
DGKIDiacylglycerol kinase. (1079 aa)
RGL4-2Ras-GEF domain-containing protein. (560 aa)
PLA2G4BPhospholipase A2. (781 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
DGKHDiacylglycerol kinase. (1220 aa)
GNA13G protein subunit alpha 13. (377 aa)
ENSCATP00000009482Ig-like domain-containing protein. (139 aa)
RALARAS like proto-oncogene A. (206 aa)
AGPAT31-acylglycerol-3-phosphate O-acyltransferase 3. (376 aa)
CYTH2Uncharacterized protein. (400 aa)
PLA2G4APhospholipase A2. (749 aa)
GRM4Glutamate metabotropic receptor 4. (912 aa)
INSRTyrosine-protein kinase receptor. (1339 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1114 aa)
ENSCATP00000007407PID domain-containing protein. (502 aa)
ENSCATP00000007240PIPK domain-containing protein. (467 aa)
ENSCATP00000006855Uncharacterized protein. (519 aa)
ENSCATP00000006715Ig-like domain-containing protein. (140 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1024 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
ENSCATP00000005869Uncharacterized protein. (526 aa)
LOC105574050Ig-like domain-containing protein. (138 aa)
RHOARas homolog family member A. (193 aa)
GPR55G protein-coupled receptor 55; Belongs to the G-protein coupled receptor 1 family. (319 aa)
ENSCATP00000005024Ig-like domain-containing protein. (150 aa)
ERASES cell expressed Ras. (233 aa)
CYTH3Cytohesin 3. (399 aa)
LPAR6Lysophosphatidic acid receptor 6; Belongs to the G-protein coupled receptor 1 family. (344 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
GRM1Glutamate metabotropic receptor 1. (1195 aa)
CEP152Centrosomal protein 152. (1706 aa)
PLA2G4CPhospholipase A2 group IVC. (531 aa)
LOC105575634Ras-GEF domain-containing protein. (577 aa)
ENSCATP00000003016Ras-GEF domain-containing protein. (500 aa)
AGPAT41-acylglycerol-3-phosphate O-acyltransferase 4. (378 aa)
LOC105585318Uncharacterized protein. (246 aa)
RALGDSUncharacterized protein. (912 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
SYKNon-specific protein-tyrosine kinase. (637 aa)
ENSCATP00000001613Ras-GEF domain-containing protein. (602 aa)
RRASRAS related. (218 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
LPAR5Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (372 aa)
DGKBDiacylglycerol kinase. (803 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
LOC105574081Ig-like domain-containing protein. (132 aa)
PLPP3acidPPc domain-containing protein. (311 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1115 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
FCER1GFc fragment of IgE receptor Ig. (111 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
LOC105575857Ras-GEF domain-containing protein. (591 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
ENSCATP00000022023Ras-GEF domain-containing protein. (466 aa)
ENSCATP00000021227Uncharacterized protein. (212 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
GAB2GRB2 associated binding protein 2. (676 aa)
ARF1Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (181 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (700 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1236 aa)
FCER1AFc fragment of IgE receptor Ia. (257 aa)
PLD1Phospholipase. (1067 aa)
LOC105577130Ig-like domain-containing protein. (133 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (754 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (139 aa)
PTPN11Protein tyrosine phosphatase non-receptor type 11. (552 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1011 aa)
JMJD7Jumonji domain containing 7. (316 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
GRM8Glutamate metabotropic receptor 8. (908 aa)
PLPP1Phospholipid phosphatase 1. (285 aa)
ENSCATP00000010452Uncharacterized protein. (596 aa)
MS4A2Membrane spanning 4-domains A2. (235 aa)
PLA2G4EPhospholipase A2. (869 aa)
LOC105575920Ig-like domain-containing protein. (140 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (925 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1161 aa)
PTGFRProstaglandin F receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
DGKZDiacylglycerol kinase. (1118 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
CSDE1Cold shock domain containing E1. (844 aa)
SHC1SHC adaptor protein 1. (584 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
RHEBRas homolog, mTORC1 binding. (196 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (283 aa)
PLA2G4FPhospholipase A2. (849 aa)
AVPR2Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (368 aa)
LPAR2Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
DGKEDiacylglycerol kinase. (567 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
RAF1Uncharacterized protein. (668 aa)
ZNF408Zinc finger protein 408. (719 aa)
LOC105585293Uncharacterized protein. (290 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
GRM3Glutamate metabotropic receptor 3. (879 aa)
PIK3R2Uncharacterized protein. (624 aa)
FYNTyrosine-protein kinase. (537 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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