STRINGSTRING
DVL2 DVL2 FZD3 FZD3 ENSCATP00000044372 ENSCATP00000044372 NF2 NF2 CTNNA3 CTNNA3 WNT9B WNT9B BMP2 BMP2 WNT7B WNT7B TP53BP2 TP53BP2 TCF7 TCF7 BBC3 BBC3 GDF6 GDF6 FZD4 FZD4 PPP2CB PPP2CB SMAD3 SMAD3 ENSCATP00000002218 ENSCATP00000002218 DLG4 DLG4 ACTG1 ACTG1 PARD6B PARD6B BMP7 BMP7 SMAD2 SMAD2 FZD9 FZD9 FZD7 FZD7 FZD5 FZD5 PARD6G PARD6G FBXW11 FBXW11 WNT16 WNT16 RASSF6 RASSF6 BTRC BTRC ENSCATP00000037714 ENSCATP00000037714 CDH1 CDH1 CCND3 CCND3 SMAD4 SMAD4 WNT10A WNT10A TEAD4 TEAD4 YWHAB YWHAB SMAD1 SMAD1 SERPINE1 SERPINE1 CCND1 CCND1 GDF5 GDF5 ENSCATP00000034500 ENSCATP00000034500 TGFBR2 TGFBR2 WNT2 WNT2 PPP2R1A PPP2R1A PPP1CC PPP1CC BMP6 BMP6 LATS2 LATS2 PPP2R2D PPP2R2D LOC105579900 LOC105579900 DLG2 DLG2 DVL3 DVL3 CTNNA1 CTNNA1 ITGB2 ITGB2 PPP2CA PPP2CA TCF7L1 TCF7L1 BIRC2 BIRC2 PATJ PATJ AXIN1 AXIN1 WWTR1 WWTR1 YWHAG YWHAG SAV1 SAV1 AFP AFP TP73 TP73 BMP5 BMP5 MYC MYC SMAD7 SMAD7 BMP8B BMP8B WNT9A WNT9A WNT8B WNT8B PPP1CB PPP1CB PPP2R2A PPP2R2A ENSCATP00000027386 ENSCATP00000027386 CCND2 CCND2 PRKCZ PRKCZ WNT11 WNT11 AMOT AMOT ACTL8 ACTL8 CCN2 CCN2 MYO15B MYO15B ENSCATP00000023795 ENSCATP00000023795 YAP1 YAP1 AREG AREG LEF1 LEF1 MOB1A MOB1A GSK3B GSK3B GLI2 GLI2 WNT6 WNT6 CTNNB1 CTNNB1 NKD2 NKD2 FZD2 FZD2 PARD3 PARD3 ENSCATP00000019935 ENSCATP00000019935 MPP5 MPP5 WNT7A WNT7A AXIN2 AXIN2 ENSCATP00000019657 ENSCATP00000019657 CTNNA2 CTNNA2 CRB2 CRB2 BMPR1A BMPR1A NKD1 NKD1 SCRIB SCRIB BMPR2 BMPR2 CSNK1D CSNK1D PRKCI PRKCI DLG5 DLG5 DVL1 DVL1 AJUBA AJUBA FGF1 FGF1 BIRC5 BIRC5 WNT5A WNT5A TCF7L2 TCF7L2 ID1 ID1 ENSCATP00000015541 ENSCATP00000015541 FZD6 FZD6 MOB1B MOB1B FZD8 FZD8 MYO15A MYO15A ACTB ACTB WNT3 WNT3 PPP1CA PPP1CA APC APC WNT5B WNT5B LLGL2 LLGL2 CRB1 CRB1 DLG3 DLG3 ENSCATP00000012820 ENSCATP00000012820 TGFB2 TGFB2 WTIP WTIP ID2 ID2 WWC1 WWC1 WNT1 WNT1 TGFBR1 TGFBR1 PPP2R2C PPP2R2C BMPR1B BMPR1B FRMD1 FRMD1 FRMD6 FRMD6 WNT4 WNT4 SNAI2 SNAI2 TGFB1 TGFB1 PPP2R1B PPP2R1B STK3 STK3 BIRC3 BIRC3 LDAH LDAH TGFB3 TGFB3 YWHAZ YWHAZ WNT3A WNT3A SOX1 SOX1 YWHAQ YWHAQ ACTL7B ACTL7B LRRC1 LRRC1 SOX3 SOX3 ACTL7A ACTL7A WNT8A WNT8A FZD10 FZD10 TEAD2 TEAD2 ACTRT1 ACTRT1 LATS1 LATS1 DLG1 DLG1 ENSCATP00000004979 ENSCATP00000004979 SOX2 SOX2 GDF7 GDF7 PARD6A PARD6A WNT2B WNT2B ENSCATP00000003364 ENSCATP00000003364 AMH AMH TEAD3 TEAD3 ENSCATP00000039367 ENSCATP00000039367 BMP4 BMP4 PPP2R2B PPP2R2B RASSF1 RASSF1 WNT10B WNT10B YWHAE YWHAE YWHAH YWHAH ENSCATP00000040576 ENSCATP00000040576 APC2 APC2 LOC105573641 LOC105573641 LLGL1 LLGL1 TEAD1 TEAD1 LIMD1 LIMD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DVL2Dishevelled segment polarity protein 2. (736 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
ENSCATP00000044372Uncharacterized protein. (731 aa)
NF2Neurofibromin 2. (595 aa)
CTNNA3Catenin alpha 3. (895 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
TP53BP2Tumor protein p53 binding protein 2. (1134 aa)
TCF7Transcription factor 7. (481 aa)
BBC3BCL2 binding component 3. (261 aa)
GDF6Growth differentiation factor 6. (455 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
SMAD3Mothers against decapentaplegic homolog. (429 aa)
ENSCATP00000002218Uncharacterized protein. (228 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (767 aa)
ACTG1Actin gamma 1. (377 aa)
PARD6BPar-6 family cell polarity regulator beta. (372 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
PARD6GPar-6 family cell polarity regulator gamma. (376 aa)
FBXW11F-box and WD repeat domain containing 11. (563 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
RASSF6Ras association domain family member 6. (337 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
ENSCATP0000003771414_3_3 domain-containing protein; Belongs to the 14-3-3 family. (232 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
TEAD4TEA domain transcription factor 4. (407 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
GDF5Growth differentiation factor 5. (499 aa)
ENSCATP00000034500Uncharacterized protein. (464 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
PPP1CCSerine/threonine-protein phosphatase. (293 aa)
BMP6Bone morphogenetic protein 6. (520 aa)
LATS2Non-specific serine/threonine protein kinase. (1086 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
LOC105579900Uncharacterized protein. (319 aa)
DLG2Discs large MAGUK scaffold protein 2. (940 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
CTNNA1Catenin alpha 1. (906 aa)
ITGB2Integrin beta. (870 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
TCF7L1Transcription factor 7 like 1. (589 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
PATJPATJ crumbs cell polarity complex component. (1790 aa)
AXIN1Axin 1. (867 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
SAV1Salvador family WW domain containing protein 1. (412 aa)
AFPAlpha fetoprotein. (622 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
SMAD7Mothers against decapentaplegic homolog. (483 aa)
BMP8BTGF_BETA_2 domain-containing protein. (402 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (295 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
ENSCATP00000027386Uncharacterized protein. (109 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
AMOTAngiomotin. (1098 aa)
ACTL8Actin like 8; Belongs to the actin family. (386 aa)
CCN2Cellular communication network factor 2. (349 aa)
MYO15BMyosin XVB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (3022 aa)
ENSCATP0000002379514_3_3 domain-containing protein; Belongs to the 14-3-3 family. (238 aa)
YAP1Yes associated protein 1. (508 aa)
AREGAmphiregulin. (274 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
MOB1AMOB kinase activator 1A. (216 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (440 aa)
GLI2GLI family zinc finger 2. (1586 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
CTNNB1Catenin beta 1. (781 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (577 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (550 aa)
PARD3Par-3 family cell polarity regulator. (1353 aa)
ENSCATP00000019935TGF_BETA_2 domain-containing protein. (383 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
AXIN2Axin 2. (843 aa)
ENSCATP00000019657Uncharacterized protein; Belongs to the actin family. (368 aa)
CTNNA2Catenin alpha 2. (953 aa)
CRB2Crumbs cell polarity complex component 2. (1285 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (470 aa)
SCRIBScribble planar cell polarity protein. (1661 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (997 aa)
CSNK1DCasein kinase 1 delta; Belongs to the protein kinase superfamily. (427 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1868 aa)
DVL1Dishevelled segment polarity protein 1. (695 aa)
AJUBAAjuba LIM protein. (538 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
BIRC5Uncharacterized protein. (147 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (382 aa)
TCF7L2Transcription factor 7 like 2. (666 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
ENSCATP00000015541Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (462 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
MOB1BMOB kinase activator 1B. (221 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (600 aa)
MYO15AMyosin XVA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (3538 aa)
ACTBUncharacterized protein. (375 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
APCAPC regulator of WNT signaling pathway. (2861 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
LLGL2LLGL scribble cell polarity complex component 2. (1008 aa)
CRB1Crumbs cell polarity complex component 1. (1394 aa)
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (863 aa)
ENSCATP0000001282014_3_3 domain-containing protein; Belongs to the 14-3-3 family. (208 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
WTIPWT1 interacting protein. (419 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
WWC1WW and C2 domain containing 1. (1119 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FRMD1FERM domain containing 1. (550 aa)
FRMD6FERM domain containing 6. (622 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
STK3Serine/threonine kinase 3. (519 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
LDAHLipid droplet associated hydrolase. (372 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
YWHAZ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
SOX1SRY-box transcription factor 1. (386 aa)
YWHAQ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (248 aa)
ACTL7BActin like 7B; Belongs to the actin family. (415 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
SOX3SRY-box transcription factor 3. (446 aa)
ACTL7AActin like 7A; Belongs to the actin family. (435 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
TEAD2TEA domain transcription factor 2. (451 aa)
ACTRT1Actin related protein T1; Belongs to the actin family. (375 aa)
LATS1Large tumor suppressor kinase 1. (1179 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (925 aa)
ENSCATP00000004979Protein kinase domain-containing protein. (393 aa)
SOX2SRY-box transcription factor 2. (319 aa)
GDF7Growth differentiation factor 7. (448 aa)
PARD6APar-6 family cell polarity regulator alpha. (345 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
ENSCATP0000000336414_3_3 domain-containing protein; Belongs to the 14-3-3 family. (217 aa)
AMHAnti-Mullerian hormone. (565 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (435 aa)
ENSCATP00000039367Uncharacterized protein. (360 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (586 aa)
RASSF1Ras association domain family member 1. (340 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
ENSCATP0000004057614_3_3 domain-containing protein; Belongs to the 14-3-3 family. (196 aa)
APC2APC regulator of WNT signaling pathway 2. (2301 aa)
LOC105573641Uncharacterized protein; Belongs to the actin family. (323 aa)
LLGL1LLGL scribble cell polarity complex component 1. (1064 aa)
TEAD1TEA domain transcription factor 1. (445 aa)
LIMD1LIM domains containing 1. (676 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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