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MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa) | ||||
CARD18 | Caspase recruitment domain family member 18. (92 aa) | ||||
NLRX1 | NLR family member X1. (794 aa) | ||||
NEK6 | NIMA related kinase 6; Belongs to the protein kinase superfamily. (347 aa) | ||||
ARHGEF33 | Rho guanine nucleotide exchange factor 33. (837 aa) | ||||
NLRC4 | NLR family CARD domain containing 4. (1024 aa) | ||||
CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa) | ||||
NLRP14 | NLR family pyrin domain containing 14. (1092 aa) | ||||
NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) | ||||
PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa) | ||||
RHOC | Ras homolog family member C. (193 aa) | ||||
CARD9 | Caspase recruitment domain family member 9. (535 aa) | ||||
ATG12 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa) | ||||
PKN2 | Protein kinase N2. (983 aa) | ||||
TP53BP1 | Tumor protein p53 binding protein 1. (1979 aa) | ||||
ATG5 | Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa) | ||||
RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) | ||||
IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa) | ||||
LOC105596237 | C-X-C motif chemokine. (154 aa) | ||||
NOD2 | Nucleotide binding oligomerization domain containing 2. (1044 aa) | ||||
CASP12 | Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. (408 aa) | ||||
NLRP13 | NLR family pyrin domain containing 13. (1044 aa) | ||||
CXCL1 | C-X-C motif chemokine. (107 aa) | ||||
ENSCATP00000016773 | Uncharacterized protein. (304 aa) | ||||
TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) | ||||
PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa) | ||||
MNDA | Myeloid cell nuclear differentiation antigen. (407 aa) | ||||
MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) | ||||
IFI16 | Interferon gamma inducible protein 16. (729 aa) | ||||
FCHO1 | FCH domain only 1. (882 aa) | ||||
LOC105574562 | DEFSN domain-containing protein. (64 aa) | ||||
ARHGEF17 | Rho guanine nucleotide exchange factor 17. (2068 aa) | ||||
ANTXR1 | ANTXR cell adhesion molecule 1. (564 aa) | ||||
MAVS | Mitochondrial antiviral signaling protein. (541 aa) | ||||
VDAC1 | Uncharacterized protein. (279 aa) | ||||
IRF7 | Interferon regulatory factor 7. (517 aa) | ||||
LOC105595226 | FIIND domain-containing protein. (349 aa) | ||||
ENSCATP00000014897 | Uncharacterized protein. (280 aa) | ||||
ENSCATP00000014557 | Uncharacterized protein. (288 aa) | ||||
URGCP | Upregulator of cell proliferation. (931 aa) | ||||
PKN1 | Protein kinase N1. (949 aa) | ||||
CASP1 | Caspase 1; Belongs to the peptidase C14A family. (441 aa) | ||||
ATL2 | Atlastin GTPase 2. (583 aa) | ||||
MEFV | MEFV innate immuity regulator, pyrin. (783 aa) | ||||
RNF144B | RBR-type E3 ubiquitin transferase. (303 aa) | ||||
IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa) | ||||
ENSCATP00000013117 | Defensin_propep domain-containing protein; Belongs to the alpha-defensin family. (76 aa) | ||||
TRAF6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa) | ||||
LOC105594209 | Defensin_propep domain-containing protein; Belongs to the alpha-defensin family. (76 aa) | ||||
PYHIN1 | Pyrin and HIN domain family member 1. (492 aa) | ||||
MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa) | ||||
ENSCATP00000011488 | Uncharacterized protein. (91 aa) | ||||
LRRC31 | Leucine rich repeat containing 31. (552 aa) | ||||
XIAP | X-linked inhibitor of apoptosis. (497 aa) | ||||
RNH1 | Ribonuclease/angiogenin inhibitor 1. (456 aa) | ||||
GAS7 | Growth arrest specific 7. (512 aa) | ||||
NLRP2 | NLR family pyrin domain containing 2. (1048 aa) | ||||
TRIM14 | Tripartite motif containing 14. (442 aa) | ||||
OTUD7A | OTU deubiquitinase 7A. (924 aa) | ||||
LOC105594210 | DEFENSIN domain-containing protein. (96 aa) | ||||
NLRP3 | NLR family pyrin domain containing 3. (1035 aa) | ||||
GABARAPL2 | GABA type A receptor associated protein like 2. (117 aa) | ||||
MFN2 | Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa) | ||||
DHX33 | DEAH-box helicase 33. (707 aa) | ||||
MAPK11 | Mitogen-activated protein kinase. (366 aa) | ||||
TXNDC2 | Thioredoxin domain-containing protein. (367 aa) | ||||
BIRC3 | Baculoviral IAP repeat containing 3. (604 aa) | ||||
LOC105584795 | AIG1-type G domain-containing protein. (251 aa) | ||||
CAMP | Cathelicidin antimicrobial peptide. (173 aa) | ||||
ENSCATP00000008179 | Uncharacterized protein. (269 aa) | ||||
NEK7 | NIMA related kinase 7; Belongs to the protein kinase superfamily. (302 aa) | ||||
IFNA6 | Interferon alpha 6. (190 aa) | ||||
BRCC3 | MPN domain-containing protein. (293 aa) | ||||
TRPV2 | Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (760 aa) | ||||
MAPK13 | Mitogen-activated protein kinase. (365 aa) | ||||
IFNB1 | Interferon beta 1. (187 aa) | ||||
TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (571 aa) | ||||
IFNAR2 | Interfer-bind domain-containing protein. (419 aa) | ||||
LOC105595225 | FIIND domain-containing protein. (515 aa) | ||||
RHOA | Ras homolog family member A. (193 aa) | ||||
ENSCATP00000005496 | Uncharacterized protein. (107 aa) | ||||
DNM1L | Dynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (802 aa) | ||||
NLRP7 | NLR family pyrin domain containing 7. (935 aa) | ||||
ARIH1 | RBR-type E3 ubiquitin transferase. (551 aa) | ||||
GBP6 | Guanylate binding protein family member 6. (633 aa) | ||||
NLRP12 | NLR family pyrin domain containing 12. (941 aa) | ||||
RNF31 | Uncharacterized protein. (1072 aa) | ||||
ENSCATP00000004161 | Uncharacterized protein. (107 aa) | ||||
LOC105579060 | HATPase_c domain-containing protein. (641 aa) | ||||
GIMAP8 | GTPase, IMAP family member 8. (665 aa) | ||||
ARRDC3 | Arrestin domain containing 3. (414 aa) | ||||
ENSCATP00000002884 | HATPase_c domain-containing protein. (680 aa) | ||||
ENSCATP00000002799 | Thioredoxin; Belongs to the thioredoxin family. (101 aa) | ||||
ARHGEF10 | Rho guanine nucleotide exchange factor 10. (1345 aa) | ||||
NUGGC | Nuclear GTPase, germinal center associated. (807 aa) | ||||
GABARAP | Uncharacterized protein. (117 aa) | ||||
P2RX7 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa) | ||||
LRRC71 | Leucine rich repeat containing 71. (559 aa) | ||||
MAPK8 | Mitogen-activated protein kinase. (384 aa) | ||||
PYDC2 | Pyrin domain containing 2. (139 aa) | ||||
NAIP | NLR family apoptosis inhibitory protein. (1403 aa) | ||||
TNF | Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa) | ||||
TYK2 | Tyrosine-protein kinase. (1164 aa) | ||||
PSTPIP1 | Proline-serine-threonine phosphatase interacting protein 1. (416 aa) | ||||
PANX1 | Pannexin; Structural component of the gap junctions and the hemichannels. (426 aa) | ||||
TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa) | ||||
ENSCATP00000018692 | MPN domain-containing protein. (273 aa) | ||||
IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) | ||||
MCUB | Mitochondrial calcium uniporter dominant negative beta subunit. (336 aa) | ||||
RNF19B | RBR-type E3 ubiquitin transferase. (719 aa) | ||||
DEFA6 | Defensin alpha 6. (100 aa) | ||||
CASP5 | Caspase 5; Belongs to the peptidase C14A family. (355 aa) | ||||
MFN1 | Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (741 aa) | ||||
CYBB | Cytochrome b-245 beta chain. (468 aa) | ||||
TXNDC8 | Thioredoxin domain containing 8. (127 aa) | ||||
IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (693 aa) | ||||
TANK | TRAF family member associated NFKB activator. (425 aa) | ||||
MAPK9 | Mitogen-activated protein kinase. (424 aa) | ||||
LOC105574568 | DEFENSIN domain-containing protein. (94 aa) | ||||
PSTPIP2 | Proline-serine-threonine phosphatase interacting protein 2. (334 aa) | ||||
RNF144A | RBR-type E3 ubiquitin transferase. (292 aa) | ||||
TXN | Thioredoxin; Belongs to the thioredoxin family. (105 aa) | ||||
MAPK12 | Mitogen-activated protein kinase. (367 aa) | ||||
ANTXRL | ANTXR like. (555 aa) | ||||
TRPM2 | Transient receptor potential cation channel subfamily M member 2. (1542 aa) | ||||
CASP4 | Caspase 4; Belongs to the peptidase C14A family. (377 aa) | ||||
BCL2L1 | BCL2 like 1. (233 aa) | ||||
ATL3 | Atlastin GTPase 3. (542 aa) | ||||
ENSCATP00000021782 | Uncharacterized protein. (915 aa) | ||||
CYBA | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (195 aa) | ||||
LOC105588756 | Caspase recruitment domain family member 17. (110 aa) | ||||
FCHO2 | FCH domain only 2. (777 aa) | ||||
LOC105594206 | Defensin_propep domain-containing protein; Belongs to the alpha-defensin family. (76 aa) | ||||
ANTXR2 | Anthrax toxin receptor; Belongs to the ATR family. (488 aa) | ||||
PRKCD | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa) | ||||
OAS3 | 2'-5'-oligoadenylate synthetase 3. (1088 aa) | ||||
AIM2 | Absent in melanoma 2. (343 aa) | ||||
PYDC1 | Pyrin domain containing 1. (87 aa) | ||||
TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa) | ||||
HSP90AB1 | Heat shock protein 90 alpha family class B member 1. (724 aa) | ||||
NLRP9 | NLR family pyrin domain containing 9. (992 aa) | ||||
FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) | ||||
ENSCATP00000024323 | Uncharacterized protein. (271 aa) | ||||
GBP7 | Guanylate binding protein 7. (623 aa) | ||||
MCU | Mitochondrial calcium uniporter. (351 aa) | ||||
ZRANB1 | Zinc finger RANBP2-type containing 1. (734 aa) | ||||
LOC105596241 | C-X-C motif chemokine. (107 aa) | ||||
XKRX | XK-related protein. (449 aa) | ||||
IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) | ||||
TXNIP | Thioredoxin interacting protein. (391 aa) | ||||
ENSCATP00000025219 | Thioredoxin domain-containing protein. (94 aa) | ||||
NLRP1 | NLR family pyrin domain containing 1. (1506 aa) | ||||
TONSL | Tonsoku like, DNA repair protein. (1390 aa) | ||||
LOC105574565 | DEFENSIN domain-containing protein. (94 aa) | ||||
SHARPIN | SHANK associated RH domain interactor. (383 aa) | ||||
PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa) | ||||
CUL9 | Cullin 9; Belongs to the cullin family. (2509 aa) | ||||
CTSB | Cathepsin B; Belongs to the peptidase C1 family. (339 aa) | ||||
CEP78 | Centrosomal protein 78. (801 aa) | ||||
CASP8 | Caspase 8; Belongs to the peptidase C14A family. (515 aa) | ||||
ANKIB1 | RBR-type E3 ubiquitin transferase. (1089 aa) | ||||
ENSCATP00000027360 | AIG1-type G domain-containing protein. (272 aa) | ||||
NME9 | NME/NM23 family member 9; Belongs to the NDK family. (330 aa) | ||||
PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1161 aa) | ||||
ENSCATP00000028019 | HATPase_c domain-containing protein. (647 aa) | ||||
CASR | Calcium sensing receptor. (1078 aa) | ||||
ARHGEF10L | Rho guanine nucleotide exchange factor 10 like. (1230 aa) | ||||
RNF19A | RBR-type E3 ubiquitin transferase. (838 aa) | ||||
ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3. (2568 aa) | ||||
NLRP10 | NLR family pyrin domain containing 10. (663 aa) | ||||
DEFA5 | Defensin_propep domain-containing protein; Belongs to the alpha-defensin family. (76 aa) | ||||
ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa) | ||||
CARD6 | Caspase recruitment domain family member 6. (1037 aa) | ||||
GIMAP6 | GTPase, IMAP family member 6. (322 aa) | ||||
GBP3 | Guanylate binding protein 3. (595 aa) | ||||
TICAM1 | Toll like receptor adaptor molecule 1. (519 aa) | ||||
GIMAP7 | GTPase, IMAP family member 7. (279 aa) | ||||
IFNAR1 | Interferon alpha and beta receptor subunit 1. (489 aa) | ||||
SGIP1 | SH3 domain GRB2 like endophilin interacting protein 1. (859 aa) | ||||
ARRDC5 | Arrestin domain containing 5. (319 aa) | ||||
TRPM7 | Transient receptor potential cation channel subfamily M member 7. (1865 aa) | ||||
OAS1 | 2'-5'-oligoadenylate synthetase 1. (452 aa) | ||||
ENSCATP00000030836 | Uncharacterized protein. (149 aa) | ||||
NOD1 | Nucleotide binding oligomerization domain containing 1. (953 aa) | ||||
NAMPT | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (499 aa) | ||||
GIMAP4 | GTPase, IMAP family member 4. (329 aa) | ||||
ATG16L1 | Autophagy related 16 like 1. (624 aa) | ||||
NLRP6 | NLR family pyrin domain containing 6. (1044 aa) | ||||
GPRC6A | G protein-coupled receptor class C group 6 member A. (928 aa) | ||||
RNASEL | Ribonuclease L. (741 aa) | ||||
GBP1 | Guanylate binding protein 1. (590 aa) | ||||
VDAC2 | Voltage dependent anion channel 2. (308 aa) | ||||
OTUD7B | OTU deubiquitinase 7B. (843 aa) | ||||
STAT1 | Signal transducer and activator of transcription. (780 aa) | ||||
ERBIN | Erbb2 interacting protein. (1418 aa) | ||||
BIRC2 | Baculoviral IAP repeat containing 2. (618 aa) | ||||
PYCARD | PYD and CARD domain containing. (195 aa) | ||||
RNF217 | RBR-type E3 ubiquitin transferase. (542 aa) | ||||
CXCL2 | C-X-C motif chemokine. (107 aa) | ||||
GSDMD | Gasdermin D. (532 aa) | ||||
LOC105574567 | DEFENSIN domain-containing protein. (94 aa) | ||||
LPP | LIM domain containing preferred translocation partner in lipoma. (613 aa) | ||||
VDAC3 | Voltage dependent anion channel 3. (284 aa) | ||||
ARRDC1 | Arrestin domain containing 1. (440 aa) | ||||
ENSCATP00000034400 | DEFENSIN domain-containing protein. (90 aa) | ||||
IRF3 | Interferon regulatory factor 3. (422 aa) | ||||
STAT2 | Signal transducer and activator of transcription. (852 aa) | ||||
GIMAP2 | GTPase, IMAP family member 2. (337 aa) | ||||
LOC105574560 | Uncharacterized protein. (67 aa) | ||||
TXN2 | Thioredoxin 2. (166 aa) | ||||
LOC105576880 | C-X-C motif chemokine. (107 aa) | ||||
ENSCATP00000036022 | Thioredoxin; Belongs to the thioredoxin family. (106 aa) | ||||
RELA | RELA proto-oncogene, NF-kB subunit. (550 aa) | ||||
OAS2 | 2'-5'-oligoadenylate synthetase 2. (718 aa) | ||||
JAK1 | Tyrosine-protein kinase. (1159 aa) | ||||
NFKBIA | NFKB inhibitor alpha. (317 aa) | ||||
IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (214 aa) | ||||
RBCK1 | RANBP2-type and C3HC4-type zinc finger containing 1. (510 aa) | ||||
NLRC5 | NLR family CARD domain containing 5. (1774 aa) | ||||
TNFAIP3 | TNF alpha induced protein 3. (790 aa) | ||||
ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1. (2745 aa) | ||||
TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa) | ||||
HSP90AA1 | Heat shock protein 90 alpha family class A member 1. (831 aa) | ||||
TBK1 | TANK binding kinase 1. (729 aa) | ||||
MAPK14 | Mitogen-activated protein kinase. (360 aa) | ||||
LRRC34 | Leucine rich repeat containing 34. (464 aa) | ||||
ARRDC4 | Arrestin domain containing 4. (418 aa) | ||||
ARRDC2 | Arrestin domain containing 2. (417 aa) | ||||
LRRC7 | Leucine rich repeat containing 7. (1542 aa) | ||||
RIPK3 | Receptor interacting serine/threonine kinase 3. (518 aa) | ||||
ATL1 | Atlastin GTPase 1. (558 aa) | ||||
GBP2 | Guanylate binding protein 2. (591 aa) | ||||
SUGT1 | SGT1 homolog, MIS12 kinetochore complex assembly cochaperone. (363 aa) | ||||
YWHAE | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa) | ||||
TRIP6 | Thyroid hormone receptor interactor 6. (476 aa) | ||||
CCL5 | C-C motif chemokine. (91 aa) | ||||
ENSCATP00000040576 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (196 aa) | ||||
RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) | ||||
NFKBIB | NFKB inhibitor beta. (356 aa) | ||||
TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa) | ||||
IRF9 | Uncharacterized protein. (195 aa) | ||||
ENSCATP00000041990 | Uncharacterized protein. (114 aa) | ||||
MAPK10 | Mitogen-activated protein kinase. (474 aa) | ||||
GABARAPL1 | GABA type A receptor associated protein like 1. (145 aa) | ||||
CCL2 | C-C motif chemokine. (99 aa) | ||||
LRRC74A | Leucine rich repeat containing 74A. (488 aa) | ||||
IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) | ||||
VCPIP1 | Valosin containing protein interacting protein 1. (1221 aa) | ||||
CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) | ||||
TAB3 | TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa) | ||||
MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (586 aa) | ||||
STING1 | Transmembrane protein 173. (379 aa) | ||||
ENSCATP00000042953 | IRF tryptophan pentad repeat domain-containing protein. (50 aa) | ||||
BCL2 | BCL2 apoptosis regulator. (239 aa) | ||||
NLRC3 | NLR family CARD domain containing 3. (1106 aa) |