STRINGSTRING
CGAS CGAS POLR2H POLR2H ENSCATP00000045271 ENSCATP00000045271 NFKB1 NFKB1 POLR3G POLR3G POLR3K POLR3K POLR1C POLR1C STING1 STING1 CHUK CHUK IL18 IL18 NFKBIB NFKBIB ENSCATP00000040988 ENSCATP00000040988 CCL5 CCL5 RIPK3 RIPK3 TBK1 TBK1 IL33 IL33 POLR2L POLR2L IL6 IL6 NFKBIA NFKBIA POLR2F POLR2F RELA RELA POLR3E POLR3E DDX58 DDX58 POLR3C POLR3C IRF3 IRF3 PIWIL2 PIWIL2 PYCARD PYCARD ENSCATP00000030836 ENSCATP00000030836 POLR3A POLR3A CXCL10 CXCL10 POLR3B POLR3B AIM2 AIM2 ENSCATP00000021744 ENSCATP00000021744 IKBKE IKBKE IKBKB IKBKB RIPK1 RIPK1 IL1B IL1B ENSCATP00000015538 ENSCATP00000015538 MAVS MAVS IRF7 IRF7 CASP1 CASP1 IKBKG IKBKG LOC105597053 LOC105597053 POLR3GL POLR3GL ADAR ADAR POLR3D POLR3D ENSCATP00000007727 ENSCATP00000007727 IFNA6 IFNA6 POLR3F POLR3F IFNB1 IFNB1 POLR3H POLR3H ENSCATP00000004161 ENSCATP00000004161 ZBP1 ZBP1 POLR2E POLR2E POLR2K POLR2K
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CGASCyclic GMP-AMP synthase. (522 aa)
POLR2HRNA polymerase II subunit H. (169 aa)
ENSCATP00000045271Uncharacterized protein. (201 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
POLR3GUncharacterized protein. (179 aa)
POLR3KDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa)
POLR1CRNA polymerase I and III subunit C. (350 aa)
STING1Transmembrane protein 173. (379 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
ENSCATP00000040988SCY domain-containing protein. (81 aa)
CCL5C-C motif chemokine. (91 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
TBK1TANK binding kinase 1. (729 aa)
IL33Interleukin 33. (270 aa)
POLR2LRNA polymerase II subunit L. (67 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (214 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
POLR2FRNA polymerase II subunit F. (158 aa)
RELARELA proto-oncogene, NF-kB subunit. (550 aa)
POLR3ERNA polymerase III subunit E. (709 aa)
DDX58DExD/H-box helicase 58. (925 aa)
POLR3CRNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (534 aa)
IRF3Interferon regulatory factor 3. (422 aa)
PIWIL2Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (973 aa)
PYCARDPYD and CARD domain containing. (195 aa)
ENSCATP00000030836Uncharacterized protein. (149 aa)
POLR3ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1390 aa)
CXCL10C-X-C motif chemokine. (98 aa)
POLR3BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1148 aa)
AIM2Absent in melanoma 2. (343 aa)
ENSCATP00000021744Uncharacterized protein. (68 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (693 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
ENSCATP00000015538C-C motif chemokine. (89 aa)
MAVSMitochondrial antiviral signaling protein. (541 aa)
IRF7Interferon regulatory factor 7. (517 aa)
CASP1Caspase 1; Belongs to the peptidase C14A family. (441 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
LOC105597053RNA_pol_L_2 domain-containing protein. (133 aa)
POLR3GLDNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (218 aa)
ADARAdenosine deaminase RNA specific. (1316 aa)
POLR3DRNA polymerase III subunit D. (397 aa)
ENSCATP00000007727RNA_pol_L_2 domain-containing protein. (126 aa)
IFNA6Interferon alpha 6. (190 aa)
POLR3FDNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (316 aa)
IFNB1Interferon beta 1. (187 aa)
POLR3HRNA polymerase III subunit H. (204 aa)
ENSCATP00000004161Uncharacterized protein. (107 aa)
ZBP1Z-DNA binding protein 1. (420 aa)
POLR2ERNA polymerase II subunit E. (210 aa)
POLR2KRNA polymerase II subunit K. (58 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
Server load: medium (66%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.