STRINGSTRING
IKBKE IKBKE ENSCATP00000000090 ENSCATP00000000090 FCER1G FCER1G TNF TNF RRAS RRAS CBLB CBLB SYK SYK MAPK8 MAPK8 CLEC7A CLEC7A CEACAM6 CEACAM6 CLEC4A CLEC4A PPP3CA PPP3CA SRC SRC CLEC1A CLEC1A ERAS ERAS RHOA RHOA RELB RELB ENSCATP00000005869 ENSCATP00000005869 AKT1 AKT1 MAPK13 MAPK13 CALML3 CALML3 TMEM52B TMEM52B PVALEF PVALEF KSR1 KSR1 ENSCATP00000008427 ENSCATP00000008427 CYLD CYLD CEACAM3 CEACAM3 MAPK11 MAPK11 NLRP3 NLRP3 IL17D IL17D NFATC1 NFATC1 ENSCATP00000010452 ENSCATP00000010452 IL23A IL23A MAPK3 MAPK3 KRAS KRAS LSP1 LSP1 IKBKG IKBKG EGR3 EGR3 CASP1 CASP1 HRAS HRAS PLK5 PLK5 MAPK1 MAPK1 PAK1 PAK1 PPP3CB PPP3CB GEM GEM IL1B IL1B IKBKB IKBKB BCL10 BCL10 CLEC4D CLEC4D AKT3 AKT3 PTPN11 PTPN11 NFKB2 NFKB2 MAPK9 MAPK9 CLEC4E CLEC4E CALM2 CALM2 PLCG2 PLCG2 MAPK12 MAPK12 PTGS2 PTGS2 NFATC4 NFATC4 RRAD RRAD IL2 IL2 LOC105598068 LOC105598068 ENSCATP00000022311 ENSCATP00000022311 EFCAB3 EFCAB3 CEACAM4 CEACAM4 PRKCD PRKCD CEACAM16 CEACAM16 PIK3R2 PIK3R2 PIK3CB PIK3CB RAF1 RAF1 ARHGEF12 ARHGEF12 IL12B IL12B CEACAM8 CEACAM8 EGR2 EGR2 PPP3R1 PPP3R1 IRF1 IRF1 IL10 IL10 CALM3 CALM3 PIK3CA PIK3CA CEACAM1 CEACAM1 CSDE1 CSDE1 CASP8 CASP8 PIK3R3 PIK3R3 PIK3R1 PIK3R1 MAP3K14 MAP3K14 ITPR3 ITPR3 ITPR2 ITPR2 NFATC3 NFATC3 LOC105598067 LOC105598067 AKT2 AKT2 CLEC1B CLEC1B ENSCATP00000032242 ENSCATP00000032242 STAT1 STAT1 PYCARD PYCARD CALM1 CALM1 MAPKAPK2 MAPKAPK2 PPP3CC PPP3CC CD209 CD209 CEACAM7 CEACAM7 CALML4 CALML4 STAT2 STAT2 MALT1 MALT1 CLEC6A CLEC6A RELA RELA NRAS NRAS CCL22 CCL22 NFKBIA NFKBIA IL6 IL6 REM1 REM1 ITPR1 ITPR1 PLK3 PLK3 BCL3 BCL3 IL12A IL12A PIK3CD PIK3CD CCL17 CCL17 MAPK14 MAPK14 CLEC4G CLEC4G ENSCATP00000040020 ENSCATP00000040020 NFATC2 NFATC2 RRAS2 RRAS2 IRF9 IRF9 MRAS MRAS MAPK10 MAPK10 CHUK CHUK ENSCATP00000042953 ENSCATP00000042953 ENSCATP00000043586 ENSCATP00000043586 ENSCATP00000044421 ENSCATP00000044421 CALML6 CALML6 NFKB1 NFKB1 EFCAB13 EFCAB13 CLEC9A CLEC9A RHOC RHOC MDM2 MDM2 CARD9 CARD9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (693 aa)
ENSCATP00000000090Uncharacterized protein. (233 aa)
FCER1GFc fragment of IgE receptor Ig. (111 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
RRASRAS related. (218 aa)
CBLBCbl proto-oncogene B. (1027 aa)
SYKNon-specific protein-tyrosine kinase. (637 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
CLEC7AC-type lectin domain containing 7A. (256 aa)
CEACAM6Uncharacterized protein. (344 aa)
CLEC4AC-type lectin domain family 4 member A. (237 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
SRCTyrosine-protein kinase. (644 aa)
CLEC1AC-type lectin domain family 1 member A. (280 aa)
ERASES cell expressed Ras. (233 aa)
RHOARas homolog family member A. (193 aa)
RELBRELB proto-oncogene, NF-kB subunit. (574 aa)
ENSCATP00000005869Uncharacterized protein. (526 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
TMEM52BTransmembrane protein 52B. (191 aa)
PVALEFParvalbumin like EF-hand containing. (133 aa)
KSR1Kinase suppressor of ras 1. (932 aa)
ENSCATP00000008427Uncharacterized protein. (282 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
CEACAM3IGv domain-containing protein. (252 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
NLRP3NLR family pyrin domain containing 3. (1035 aa)
IL17DInterleukin 17D. (202 aa)
NFATC1Nuclear factor of activated T cells 1. (973 aa)
ENSCATP00000010452Uncharacterized protein. (596 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
LSP1Lymphocyte specific protein 1. (453 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
EGR3Early growth response 3. (387 aa)
CASP1Caspase 1; Belongs to the peptidase C14A family. (441 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PLK5Polo like kinase 5. (336 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
BCL10BCL10 immune signaling adaptor. (311 aa)
CLEC4DC-type lectin domain family 4 member D. (215 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PTPN11Protein tyrosine phosphatase non-receptor type 11. (552 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CLEC4EC-type lectin domain family 4 member E. (219 aa)
CALM2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1236 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
NFATC4Nuclear factor of activated T cells 4. (961 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
LOC105598068Uncharacterized protein. (427 aa)
ENSCATP00000022311Uncharacterized protein. (425 aa)
EFCAB3EF-hand calcium binding domain 3. (470 aa)
CEACAM4Carcinoembryonic antigen related cell adhesion molecule 4. (249 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
CEACAM16Carcinoembryonic antigen related cell adhesion molecule 16. (425 aa)
PIK3R2Uncharacterized protein. (624 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
RAF1Uncharacterized protein. (668 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (328 aa)
CEACAM8Carcinoembryonic antigen related cell adhesion molecule 8. (349 aa)
EGR2Early growth response 2. (476 aa)
PPP3R1Uncharacterized protein. (189 aa)
IRF1Interferon regulatory factor. (325 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
CALM3Calmodulin 3. (149 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
CEACAM1Uncharacterized protein. (525 aa)
CSDE1Cold shock domain containing E1. (844 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (515 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2568 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
NFATC3Nuclear factor of activated T cells 3. (1064 aa)
LOC105598067Uncharacterized protein. (425 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CLEC1BC-type lectin domain family 1 member B. (229 aa)
ENSCATP00000032242Uncharacterized protein; Belongs to the calmodulin family. (128 aa)
STAT1Signal transducer and activator of transcription. (780 aa)
PYCARDPYD and CARD domain containing. (195 aa)
CALM1Calmodulin 1. (149 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PPP3CCSerine/threonine-protein phosphatase. (438 aa)
CD209CD209 molecule. (404 aa)
CEACAM7Carcinoembryonic antigen related cell adhesion molecule 7. (264 aa)
CALML4Calmodulin like 4. (193 aa)
STAT2Signal transducer and activator of transcription. (852 aa)
MALT1MALT1 paracaspase. (824 aa)
CLEC6AC-type lectin domain containing 6A. (209 aa)
RELARELA proto-oncogene, NF-kB subunit. (550 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
CCL22C-C motif chemokine ligand 22. (93 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (214 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2745 aa)
PLK3Serine/threonine-protein kinase PLK. (673 aa)
BCL3BCL3 transcription coactivator. (454 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CCL17C-C motif chemokine. (91 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CLEC4GC-type lectin domain family 4 member G. (293 aa)
ENSCATP00000040020Uncharacterized protein; Belongs to the calmodulin family. (91 aa)
NFATC2Nuclear factor of activated T cells 2. (921 aa)
RRAS2RAS related 2. (204 aa)
IRF9Uncharacterized protein. (195 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
ENSCATP00000042953IRF tryptophan pentad repeat domain-containing protein. (50 aa)
ENSCATP00000043586Uncharacterized protein; Belongs to the calmodulin family. (128 aa)
ENSCATP00000044421Uncharacterized protein. (441 aa)
CALML6Calmodulin like 6. (181 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
EFCAB13EF-hand calcium binding domain 13. (972 aa)
CLEC9AC-type lectin domain containing 9A. (216 aa)
RHOCRas homolog family member C. (193 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
CARD9Caspase recruitment domain family member 9. (535 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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