STRINGSTRING
TNFAIP3 TNFAIP3 TRAF2 TRAF2 TNF TNF ENSCATP00000001233 ENSCATP00000001233 MAPK6 MAPK6 MAPK8 MAPK8 ENSCATP00000002884 ENSCATP00000002884 LOC105579060 LOC105579060 ENSCATP00000004013 ENSCATP00000004013 MAPK4 MAPK4 HSP90B1 HSP90B1 TRAF3 TRAF3 MAPK13 MAPK13 CEBPB CEBPB IL25 IL25 ENSCATP00000007830 ENSCATP00000007830 MAPK11 MAPK11 IL17D IL17D CASP3 CASP3 CCL20 CCL20 MMP9 MMP9 MAPK3 MAPK3 TRADD TRADD TRAF6 TRAF6 IKBKG IKBKG IL13 IL13 MUC5B MUC5B LOC105574562 LOC105574562 IL17B IL17B MAPK1 MAPK1 ELAVL1 ELAVL1 TAB2 TAB2 IL5 IL5 MMP10 MMP10 CXCL1 CXCL1 IL17RC IL17RC LOC105596237 LOC105596237 IL1B IL1B IKBKB IKBKB IKBKE IKBKE MAPK9 MAPK9 FOSL1 FOSL1 MAPK7 MAPK7 MAPK12 MAPK12 PTGS2 PTGS2 GSK3B GSK3B S100A7L2 S100A7L2 IFNG IFNG S100A7A S100A7A CSF3 CSF3 IL17RE IL17RE HSP90AB1 HSP90AB1 LCN2 LCN2 FADD FADD LOC105596240 LOC105596240 CXCL10 CXCL10 LOC105596241 LOC105596241 TRAF3IP2 TRAF3IP2 IL17A IL17A CASP8 CASP8 MMP13 MMP13 ENSCATP00000028019 ENSCATP00000028019 ENSCATP00000028909 ENSCATP00000028909 CCL11 CCL11 CCL7 CCL7 ANAPC5 ANAPC5 CXCL2 CXCL2 MMP3 MMP3 LOC105576880 LOC105576880 RELA RELA JUND JUND NFKBIA NFKBIA IL6 IL6 IL17F IL17F TRAF5 TRAF5 S100A9 S100A9 HSP90AA1 HSP90AA1 TBK1 TBK1 MAPK15 MAPK15 ENSCATP00000038453 ENSCATP00000038453 CCL17 CCL17 MAPK14 MAPK14 S100A8 S100A8 CSF2 CSF2 SRSF1 SRSF1 IL17RB IL17RB FOSB FOSB IL4 IL4 MAPK10 MAPK10 CCL2 CCL2 CHUK CHUK TAB3 TAB3 MAP3K7 MAP3K7 MMP1 MMP1 IL17C IL17C IL17RA IL17RA CXCL8 CXCL8 USP25 USP25 FOS FOS NFKB1 NFKB1 CXCL6 CXCL6 TRAF4 TRAF4 LOC105576878 LOC105576878
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNFAIP3TNF alpha induced protein 3. (790 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
ENSCATP00000001233RRM domain-containing protein. (118 aa)
MAPK6Mitogen-activated protein kinase 6. (721 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
ENSCATP00000002884HATPase_c domain-containing protein. (680 aa)
LOC105579060HATPase_c domain-containing protein. (641 aa)
ENSCATP00000004013Uncharacterized protein. (711 aa)
MAPK4Mitogen-activated protein kinase 4. (587 aa)
HSP90B1Heat shock protein 90 beta family member 1. (804 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (571 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CEBPBCCAAT/enhancer-binding protein. (344 aa)
IL25Interleukin 25. (161 aa)
ENSCATP00000007830Uncharacterized protein. (436 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
IL17DInterleukin 17D. (202 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
CCL20C-C motif chemokine. (96 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
TRADDTNFRSF1A associated via death domain. (308 aa)
TRAF6TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
IL13Interleukin 13. (146 aa)
MUC5BMucin 5B, oligomeric mucus/gel-forming. (5052 aa)
LOC105574562DEFSN domain-containing protein. (64 aa)
IL17BInterleukin 17B. (180 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
MMP10Matrix metallopeptidase 10. (476 aa)
CXCL1C-X-C motif chemokine. (107 aa)
IL17RCInterleukin 17 receptor C. (780 aa)
LOC105596237C-X-C motif chemokine. (154 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (693 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (440 aa)
S100A7L2S100 calcium binding protein A7 like 2. (86 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
S100A7AProtein S100; Belongs to the S-100 family. (101 aa)
CSF3Colony stimulating factor 3. (204 aa)
IL17REInterleukin 17 receptor E. (698 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
LCN2Lipocalin 2; Belongs to the calycin superfamily. Lipocalin family. (200 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
LOC105596240C-X-C motif chemokine. (114 aa)
CXCL10C-X-C motif chemokine. (98 aa)
LOC105596241C-X-C motif chemokine. (107 aa)
TRAF3IP2TRAF3 interacting protein 2. (580 aa)
IL17AInterleukin 17A. (155 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (515 aa)
MMP13Matrix metallopeptidase 13. (501 aa)
ENSCATP00000028019HATPase_c domain-containing protein. (647 aa)
ENSCATP00000028909Protein kinase domain-containing protein. (238 aa)
CCL11C-C motif chemokine. (97 aa)
CCL7C-C motif chemokine. (109 aa)
ANAPC5Anaphase promoting complex subunit 5. (679 aa)
CXCL2C-X-C motif chemokine. (107 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
LOC105576880C-X-C motif chemokine. (107 aa)
RELARELA proto-oncogene, NF-kB subunit. (550 aa)
JUNDBZIP domain-containing protein. (296 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (214 aa)
IL17FInterleukin 17F. (163 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
S100A9Protein S100; Belongs to the S-100 family. (114 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (831 aa)
TBK1TANK binding kinase 1. (729 aa)
MAPK15Mitogen-activated protein kinase. (544 aa)
ENSCATP00000038453Uncharacterized protein; Belongs to the peptidase C14A family. (262 aa)
CCL17C-C motif chemokine. (91 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
S100A8Protein S100; Belongs to the S-100 family. (93 aa)
CSF2Colony stimulating factor 2. (144 aa)
SRSF1Uncharacterized protein. (253 aa)
IL17RBInterleukin 17 receptor B. (502 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (153 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
CCL2C-C motif chemokine. (99 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (586 aa)
MMP1Matrix metallopeptidase 1. (469 aa)
IL17CInterleukin 17C. (197 aa)
IL17RAInterleukin 17 receptor A. (837 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
USP25Ubiquitin specific peptidase 25; Belongs to the peptidase C19 family. (1125 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
CXCL6C-X-C motif chemokine. (123 aa)
TRAF4TNF receptor-associated factor. (470 aa)
LOC105576878SCY domain-containing protein. (114 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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