STRINGSTRING
PRKCQ PRKCQ LOC105575603 LOC105575603 TYK2 TYK2 ENSCATP00000001099 ENSCATP00000001099 MAPK8 MAPK8 STAT5B STAT5B TBX21 TBX21 PPP3CA PPP3CA STAT4 STAT4 RUNX3 RUNX3 JAG2 JAG2 IL12RB2 IL12RB2 IL2RA IL2RA MAPK13 MAPK13 JAK3 JAK3 IFNGR2 IFNGR2 NOTCH1 NOTCH1 LOC105575006 LOC105575006 HLA-DPA1 HLA-DPA1 JAK2 JAK2 NFKBIE NFKBIE MAPK11 MAPK11 ENSCATP00000010103 ENSCATP00000010103 NFATC1 NFATC1 MAML3 MAML3 MAPK3 MAPK3 HLA-DQB1 HLA-DQB1 DLL3 DLL3 HLA-DMA HLA-DMA IKBKG IKBKG IL13 IL13 LOC105575604 LOC105575604 ENSCATP00000014761 ENSCATP00000014761 MAPK1 MAPK1 RBPJL RBPJL IL2RG IL2RG PPP3CB PPP3CB IL5 IL5 ENSCATP00000018187 ENSCATP00000018187 IL12RB1 IL12RB1 IKBKB IKBKB LOC105575605 LOC105575605 MAPK9 MAPK9 MAPK12 MAPK12 MAML2 MAML2 LOC105576725 LOC105576725 LAT LAT IL2 IL2 LOC105575013 LOC105575013 PLCG1 PLCG1 IFNG IFNG LOC105600307 LOC105600307 MAML1 MAML1 HLA-DOA HLA-DOA IL12B IL12B HLA-DRA HLA-DRA CD3D CD3D CD247 CD247 NFKB1 NFKB1 FOS FOS LCK LCK RBPJ RBPJ CHUK CHUK MAPK10 MAPK10 NOTCH3 NOTCH3 CD3E CD3E NFKBIB NFKBIB IL4 IL4 NFATC2 NFATC2 TRBV11-1 TRBV11-1 TRBV10-1 TRBV10-1 CD3G CD3G MAPK14 MAPK14 MAF MAF NOTCH2 NOTCH2 IL12A IL12A NFKBIA NFKBIA JAK1 JAK1 RELA RELA LOC105583891 LOC105583891 STAT6 STAT6 JAG1 JAG1 ENSCATP00000034919 ENSCATP00000034919 LOC105600305 LOC105600305 PPP3CC PPP3CC STAT1 STAT1 IL2RB IL2RB DLL1 DLL1 STAT5A STAT5A ZAP70 ZAP70 CD4 CD4 HLA-DPB1 HLA-DPB1 IL4R IL4R DLL4 DLL4 NFATC3 NFATC3 ENSCATP00000028696 ENSCATP00000028696 TRAC TRAC ENSCATP00000025923 ENSCATP00000025923 PPP3R1 PPP3R1 LOC105576724 LOC105576724
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
LOC105575603Ig-like domain-containing protein. (284 aa)
TYK2Tyrosine-protein kinase. (1164 aa)
ENSCATP00000001099Ig-like domain-containing protein. (272 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
TBX21T-box transcription factor 21. (535 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
STAT4Signal transducer and activator of transcription. (710 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1162 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (847 aa)
IL2RAInterleukin 2 receptor subunit alpha. (272 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
JAK3Tyrosine-protein kinase. (1124 aa)
IFNGR2Interferon gamma receptor 2. (340 aa)
NOTCH1Notch receptor 1. (2547 aa)
LOC105575006Ig-like domain-containing protein. (263 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
JAK2Tyrosine-protein kinase. (1137 aa)
NFKBIENFKB inhibitor epsilon. (484 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
ENSCATP00000010103Ig-like domain-containing protein. (273 aa)
NFATC1Nuclear factor of activated T cells 1. (973 aa)
MAML3Mastermind like transcriptional coactivator 3. (1134 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 1. (284 aa)
DLL3Delta like canonical Notch ligand 3. (618 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (290 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
IL13Interleukin 13. (146 aa)
LOC105575604Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
ENSCATP00000014761Ig-like domain-containing protein. (262 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
RBPJLRecombination signal binding protein for immunoglobulin kappa J region like. (522 aa)
IL2RGFibronectin type-III domain-containing protein. (369 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
ENSCATP00000018187Ig-like domain-containing protein. (265 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (629 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
LOC105575605Ig-like domain-containing protein. (263 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
MAML2Mastermind like transcriptional coactivator 2. (1151 aa)
LOC105576725Ig-like domain-containing protein. (283 aa)
LATLinker for activation of T cells. (270 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
LOC105575013Ig-like domain-containing protein. (273 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
LOC105600307Ig-like domain-containing protein. (268 aa)
MAML1Mastermind like transcriptional coactivator 1. (963 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (298 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (328 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
CD3DCD3d molecule. (171 aa)
CD247CD247 molecule. (165 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
LCKTyrosine-protein kinase. (540 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (488 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
NOTCH3Notch receptor 3. (2321 aa)
CD3ECD3e molecule. (198 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (153 aa)
NFATC2Nuclear factor of activated T cells 2. (921 aa)
TRBV11-1T cell receptor beta variable 11-1. (142 aa)
TRBV10-1T cell receptor beta variable 10-1(gene/pseudogene). (131 aa)
CD3GCD3g molecule. (181 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAFMAF bZIP transcription factor; Belongs to the bZIP family. (340 aa)
NOTCH2Notch receptor 2. (2610 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
RELARELA proto-oncogene, NF-kB subunit. (550 aa)
LOC105583891Ig-like domain-containing protein. (339 aa)
STAT6Signal transducer and activator of transcription. (737 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
ENSCATP00000034919Ig-like domain-containing protein. (264 aa)
LOC105600305Ig-like domain-containing protein; Belongs to the MHC class II family. (219 aa)
PPP3CCSerine/threonine-protein phosphatase. (438 aa)
STAT1Signal transducer and activator of transcription. (780 aa)
IL2RBInterleukin 2 receptor subunit beta. (551 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (462 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
IL4RInterleukin 4 receptor. (825 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (713 aa)
NFATC3Nuclear factor of activated T cells 3. (1064 aa)
ENSCATP00000028696Ig-like domain-containing protein. (133 aa)
TRACT cell receptor alpha constant. (110 aa)
ENSCATP00000025923Uncharacterized protein. (618 aa)
PPP3R1Uncharacterized protein. (189 aa)
LOC105576724Ig-like domain-containing protein. (283 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
Server load: low (18%) [HD]