STRINGSTRING
VAV3 VAV3 MAP2K6 MAP2K6 GRB2 GRB2 MAPK10 MAPK10 IL4 IL4 SOS2 SOS2 CSF2 CSF2 MAPK14 MAPK14 PIK3CD PIK3CD ENSCATP00000037667 ENSCATP00000037667 MAP2K4 MAP2K4 IL3 IL3 NRAS NRAS PLA2G4D PLA2G4D RAC2 RAC2 PTK6 PTK6 AKT2 AKT2 MAP2K1 MAP2K1 SRMS SRMS PIK3R1 PIK3R1 PIK3R3 PIK3R3 CSDE1 CSDE1 PIK3CA PIK3CA PLA2G4F PLA2G4F VAV2 VAV2 RAF1 RAF1 PIK3CB PIK3CB PIK3R2 PIK3R2 FYN FYN PLCG1 PLCG1 LAT LAT GAB2 GAB2 MAPK12 MAPK12 BTK BTK PLCG2 PLCG2 FCER1A FCER1A MAPK9 MAPK9 JMJD7 JMJD7 AKT3 AKT3 VAV1 VAV1 PDPK1 PDPK1 PLA2G4B PLA2G4B IL5 IL5 MAP2K3 MAP2K3 MAPK1 MAPK1 ENSCATP00000015421 ENSCATP00000015421 ENSCATP00000015134 ENSCATP00000015134 HRAS HRAS PRKCA PRKCA GAB4 GAB4 MAP2K2 MAP2K2 IL13 IL13 ENSCATP00000012908 ENSCATP00000012908 RAC1 RAC1 LYN LYN ALOX5 ALOX5 ALOX5AP ALOX5AP KRAS KRAS MAPK3 MAPK3 LOC105575920 LOC105575920 RAC3 RAC3 PLA2G4E PLA2G4E MS4A2 MS4A2 ENSCATP00000010452 ENSCATP00000010452 LOC105577130 LOC105577130 MAPK11 MAPK11 ENSCATP00000009482 ENSCATP00000009482 PLA2G4A PLA2G4A ENSCATP00000006715 ENSCATP00000006715 MAPK13 MAPK13 AKT1 AKT1 LOC105574050 LOC105574050 ENSCATP00000005024 ENSCATP00000005024 ERAS ERAS LCP2 LCP2 INPP5D INPP5D SOS1 SOS1 PLA2G4C PLA2G4C MAP2K7 MAP2K7 MAPK8 MAPK8 SYK SYK TNF TNF LOC105574081 LOC105574081 FCER1G FCER1G ENSCATP00000000012 ENSCATP00000000012
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (153 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1327 aa)
CSF2Colony stimulating factor 2. (144 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ENSCATP00000037667Protein kinase domain-containing protein. (365 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (416 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (151 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PLA2G4DPhospholipase A2. (817 aa)
RAC2Rac family small GTPase 2. (192 aa)
PTK6Tyrosine-protein kinase. (507 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (344 aa)
SRMSTyrosine-protein kinase. (492 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
CSDE1Cold shock domain containing E1. (844 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PLA2G4FPhospholipase A2. (849 aa)
VAV2Vav guanine nucleotide exchange factor 2. (868 aa)
RAF1Uncharacterized protein. (668 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
PIK3R2Uncharacterized protein. (624 aa)
FYNTyrosine-protein kinase. (537 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
LATLinker for activation of T cells. (270 aa)
GAB2GRB2 associated binding protein 2. (676 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
BTKTyrosine-protein kinase. (659 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1236 aa)
FCER1AFc fragment of IgE receptor Ia. (257 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
JMJD7Jumonji domain containing 7. (316 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
VAV1Vav guanine nucleotide exchange factor 1. (856 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (534 aa)
PLA2G4BPhospholipase A2. (781 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ENSCATP00000015421Ig-like domain-containing protein. (140 aa)
ENSCATP00000015134Ig-like domain-containing protein. (173 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
GAB4GRB2 associated binding protein family member 4. (536 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
IL13Interleukin 13. (146 aa)
ENSCATP00000012908Ig-like domain-containing protein. (144 aa)
RAC1Uncharacterized protein. (212 aa)
LYNTyrosine-protein kinase. (507 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
ALOX5APArachidonate 5-lipoxygenase activating protein. (218 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
LOC105575920Ig-like domain-containing protein. (140 aa)
RAC3Rac family small GTPase 3. (205 aa)
PLA2G4EPhospholipase A2. (869 aa)
MS4A2Membrane spanning 4-domains A2. (235 aa)
ENSCATP00000010452Uncharacterized protein. (596 aa)
LOC105577130Ig-like domain-containing protein. (133 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
ENSCATP00000009482Ig-like domain-containing protein. (139 aa)
PLA2G4APhospholipase A2. (749 aa)
ENSCATP00000006715Ig-like domain-containing protein. (140 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC105574050Ig-like domain-containing protein. (138 aa)
ENSCATP00000005024Ig-like domain-containing protein. (150 aa)
ERASES cell expressed Ras. (233 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1184 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
PLA2G4CPhospholipase A2 group IVC. (531 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (517 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
SYKNon-specific protein-tyrosine kinase. (637 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC105574081Ig-like domain-containing protein. (132 aa)
FCER1GFc fragment of IgE receptor Ig. (111 aa)
ENSCATP00000000012Protein kinase domain-containing protein. (231 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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