STRINGSTRING
CLDN11 CLDN11 PXN PXN RAP1A RAP1A CTNNA3 CTNNA3 RHOC RHOC CLDN10 CLDN10 CLDN19 CLDN19 ENSCATP00000004469 ENSCATP00000004469 CLDN14 CLDN14 LOC105571986 LOC105571986 VCL VCL MMP2 MMP2 ITGAM ITGAM AFDN AFDN CXCR4 CXCR4 VAV3 VAV3 CXCL12 CXCL12 ACTG1 ACTG1 CLDN24 CLDN24 NCF1 NCF1 CLDN9 CLDN9 JAM2 JAM2 MYL12A MYL12A SIPA1 SIPA1 CTNND1 CTNND1 RAC2 RAC2 TXK TXK LOC105579900 LOC105579900 CTNNA1 CTNNA1 ITGB2 ITGB2 ACTN1 ACTN1 GABPA GABPA ENSCATP00000031894 ENSCATP00000031894 ITGB1 ITGB1 NCF4 NCF4 BCAR1 BCAR1 VCAM1 VCAM1 CD99L2 CD99L2 CDH5 CDH5 PIK3R1 PIK3R1 PIK3R3 PIK3R3 PIK3CA PIK3CA OCLN OCLN ENSCATP00000026377 ENSCATP00000026377 ICAM1 ICAM1 VAV2 VAV2 CLDN1 CLDN1 ACTL8 ACTL8 PIK3CB PIK3CB PIK3R2 PIK3R2 CLDN18 CLDN18 ARHGAP5 ARHGAP5 MSN MSN PLCG1 PLCG1 CLDN7 CLDN7 CYBA CYBA CDC42 CDC42 CTNNB1 CTNNB1 PRKCG PRKCG MAPK12 MAPK12 LPXN LPXN PLCG2 PLCG2 PTPN11 PTPN11 ENSCATP00000019657 ENSCATP00000019657 RAPGEF4 RAPGEF4 CTNNA2 CTNNA2 MYL5 MYL5 CYBB CYBB GNAI1 GNAI1 CLDN15 CLDN15 VAV1 VAV1 PTK2B PTK2B JAM3 JAM3 CLDN16 CLDN16 ENSCATP00000017084 ENSCATP00000017084 MYL10 MYL10 RASSF5 RASSF5 MYL12B MYL12B ROCK1 ROCK1 MYL9 MYL9 THY1 THY1 XG XG ITK ITK PRKCA PRKCA ACTB ACTB GNAI3 GNAI3 ENSCATP00000013162 ENSCATP00000013162 EZR EZR F11R F11R RAC1 RAC1 ACTN4 ACTN4 ENSCATP00000011506 ENSCATP00000011506 RAPGEF3 RAPGEF3 MMP9 MMP9 ITGAL ITGAL ITGA4 ITGA4 MAPK11 MAPK11 PECAM1 PECAM1 ARHGAP35 ARHGAP35 PRKCB PRKCB CD99 CD99 CLDN8 CLDN8 ACTL7B ACTL7B CLDN2 CLDN2 ACTL7A ACTL7A RHOH RHOH CLDN22 CLDN22 MAPK13 MAPK13 CLDN3 CLDN3 ENSCATP00000005869 ENSCATP00000005869 CLDN5 CLDN5 ACTRT1 ACTRT1 CLDN4 CLDN4 RHOA RHOA PTK2 PTK2 NOXA1 NOXA1 PIK3CD PIK3CD MAPK14 MAPK14 ENSCATP00000039367 ENSCATP00000039367 NCF2 NCF2 VASP VASP LOC105573641 LOC105573641 ROCK2 ROCK2 MYL2 MYL2 GNAI2 GNAI2 ENSCATP00000042801 ENSCATP00000042801 MYLPF MYLPF ESAM ESAM RAP1B RAP1B ENSCATP00000044372 ENSCATP00000044372 ENSCATP00000044421 ENSCATP00000044421
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
PXNPaxillin. (1082 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
CTNNA3Catenin alpha 3. (895 aa)
RHOCRas homolog family member C. (193 aa)
CLDN10Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (228 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
ENSCATP00000004469Uncharacterized protein. (191 aa)
CLDN14Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (236 aa)
LOC105571986Uncharacterized protein. (189 aa)
VCLVinculin. (1134 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
AFDNAfadin, adherens junction formation factor. (1834 aa)
CXCR4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (408 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
ACTG1Actin gamma 1. (377 aa)
CLDN24Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
NCF1Neutrophil cytosolic factor 1. (423 aa)
CLDN9Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
JAM2Junctional adhesion molecule 2. (312 aa)
MYL12AMyosin light chain 12A. (177 aa)
SIPA1Signal-induced proliferation-associated 1. (1042 aa)
CTNND1Catenin delta 1. (971 aa)
RAC2Rac family small GTPase 2. (192 aa)
TXKTyrosine-protein kinase. (527 aa)
LOC105579900Uncharacterized protein. (319 aa)
CTNNA1Catenin alpha 1. (906 aa)
ITGB2Integrin beta. (870 aa)
ACTN1Actinin alpha 1. (914 aa)
GABPAGA binding protein transcription factor subunit alpha. (454 aa)
ENSCATP00000031894Uncharacterized protein. (39 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
NCF4Neutrophil cytosolic factor 4. (366 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
CD99L2CD99 molecule like 2. (261 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (785 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (505 aa)
ENSCATP00000026377Uncharacterized protein. (170 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
VAV2Vav guanine nucleotide exchange factor 2. (868 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
ACTL8Actin like 8; Belongs to the actin family. (386 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
PIK3R2Uncharacterized protein. (624 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
ARHGAP5Rho GTPase activating protein 5. (1502 aa)
MSNMoesin. (577 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
CLDN7Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (195 aa)
CDC42Uncharacterized protein. (191 aa)
CTNNB1Catenin beta 1. (781 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (386 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1236 aa)
PTPN11Protein tyrosine phosphatase non-receptor type 11. (552 aa)
ENSCATP00000019657Uncharacterized protein; Belongs to the actin family. (368 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1011 aa)
CTNNA2Catenin alpha 2. (953 aa)
MYL5Myosin light chain 5. (173 aa)
CYBBCytochrome b-245 beta chain. (468 aa)
GNAI1G protein subunit alpha i1. (330 aa)
CLDN15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (228 aa)
VAV1Vav guanine nucleotide exchange factor 1. (856 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
JAM3Junctional adhesion molecule 3. (329 aa)
CLDN16Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (235 aa)
ENSCATP00000017084Uncharacterized protein. (185 aa)
MYL10Myosin light chain 10. (226 aa)
RASSF5Ras association domain family member 5. (418 aa)
MYL12BMyosin light chain 12B. (172 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1337 aa)
MYL9Myosin light chain 9. (172 aa)
THY1Thy-1 cell surface antigen. (161 aa)
XGXg glycoprotein (Xg blood group). (193 aa)
ITKTyrosine-protein kinase. (620 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
ACTBUncharacterized protein. (375 aa)
GNAI3G protein subunit alpha i3. (354 aa)
ENSCATP00000013162Uncharacterized protein. (173 aa)
EZREzrin. (603 aa)
F11RF11 receptor. (259 aa)
RAC1Uncharacterized protein. (212 aa)
ACTN4Actinin alpha 4. (931 aa)
ENSCATP00000011506Uncharacterized protein. (1247 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (925 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1155 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (721 aa)
ARHGAP35Rho GTPase activating protein 35. (1499 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
CD99CD99 molecule (Xg blood group). (185 aa)
CLDN8Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
ACTL7BActin like 7B; Belongs to the actin family. (415 aa)
CLDN2Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa)
ACTL7AActin like 7A; Belongs to the actin family. (435 aa)
RHOHRas homolog family member H. (191 aa)
CLDN22Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
ENSCATP00000005869Uncharacterized protein. (526 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
ACTRT1Actin related protein T1; Belongs to the actin family. (375 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
RHOARas homolog family member A. (193 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1068 aa)
NOXA1NADPH oxidase activator 1. (483 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ENSCATP00000039367Uncharacterized protein. (360 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
VASPVasodilator stimulated phosphoprotein. (431 aa)
LOC105573641Uncharacterized protein; Belongs to the actin family. (323 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
MYL2Myosin light chain 2. (166 aa)
GNAI2G protein subunit alpha i2. (355 aa)
ENSCATP00000042801Uncharacterized protein. (136 aa)
MYLPFMyosin light chain, phosphorylatable, fast skeletal muscle. (200 aa)
ESAMEndothelial cell adhesion molecule. (390 aa)
RAP1BUncharacterized protein. (184 aa)
ENSCATP00000044372Uncharacterized protein. (731 aa)
ENSCATP00000044421Uncharacterized protein. (441 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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