STRINGSTRING
SLC18A2 SLC18A2 GSK3A GSK3A PLCB1 PLCB1 PPP2R5A PPP2R5A KIF5C KIF5C CALML6 CALML6 FOS FOS PPP1R1B PPP1R1B PPP2R5B PPP2R5B PRKACA PRKACA ENSCATP00000043586 ENSCATP00000043586 GNAO1 GNAO1 CACNA1C CACNA1C MAPK10 MAPK10 GNAI2 GNAI2 LOC105578799 LOC105578799 ENSCATP00000040020 ENSCATP00000040020 PPP2R2B PPP2R2B PRKACB PRKACB MAPK14 MAPK14 ENSCATP00000038494 ENSCATP00000038494 CAMK2G CAMK2G ITPR1 ITPR1 ENSCATP00000035075 ENSCATP00000035075 ENSCATP00000035073 ENSCATP00000035073 CREB3L3 CREB3L3 GNGT2 GNGT2 DRD2 DRD2 PPP2R1A PPP2R1A CALML4 CALML4 PPP1CC PPP1CC PPP2R2D PPP2R2D PPP2R5D PPP2R5D ARRB1 ARRB1 ENSCATP00000033138 ENSCATP00000033138 PPP2CA PPP2CA PPP3CC PPP3CC CALM1 CALM1 CREB5 CREB5 GNB2 GNB2 ENSCATP00000032242 ENSCATP00000032242 GRIA4 GRIA4 GNG2 GNG2 AKT2 AKT2 GNAS GNAS GRIA1 GRIA1 KIF5A KIF5A PPP2R3B PPP2R3B GNG3 GNG3 GNG8 GNG8 GNG4 GNG4 CREB3 CREB3 ITPR2 ITPR2 ITPR3 ITPR3 PPP1CB PPP1CB PLCB2 PLCB2 KCNJ6 KCNJ6 CREB1 CREB1 PPP2R2A PPP2R2A PPP2R3A PPP2R3A ENSCATP00000027386 ENSCATP00000027386 GRIA3 GRIA3 PLCB4 PLCB4 ADCY5 ADCY5 CALM3 CALM3 ENSCATP00000026030 ENSCATP00000026030 CAMK2D CAMK2D LOC105601524 LOC105601524 CREB3L1 CREB3L1 DRD3 DRD3 ARSI ARSI DRD4 DRD4 CAMK2A CAMK2A GSK3B GSK3B GNGT1 GNGT1 CREB3L2 CREB3L2 PRKCG PRKCG MAPK12 MAPK12 CAMK2B CAMK2B MAOB MAOB CALM2 CALM2 MAPK9 MAPK9 TH TH AKT3 AKT3 GNAI1 GNAI1 ENSCATP00000018990 ENSCATP00000018990 GRIA2 GRIA2 GNG13 GNG13 CACNA1A CACNA1A PPP3CB PPP3CB PLCB3 PLCB3 PPP2R5C PPP2R5C PPP2R3C PPP2R3C PRKCA PRKCA PPP1CA PPP1CA GNAI3 GNAI3 ATF6B ATF6B ATF4 ATF4 GNAL GNAL SLC18A1 SLC18A1 CREB3L4 CREB3L4 GRIN2A GRIN2A SCN1A SCN1A PPP2R2C PPP2R2C CACNA1B CACNA1B CACNA1D CACNA1D MAPK11 MAPK11 MAOA MAOA PPP2R1B PPP2R1B COMT COMT KCNJ9 KCNJ9 PRKCB PRKCB GNB3 GNB3 LOC105581531 LOC105581531 PVALEF PVALEF GNB5 GNB5 CALML3 CALML3 MAPK13 MAPK13 PPP2R5E PPP2R5E AKT1 AKT1 ARR3 ARR3 ARNTL ARNTL GNG5 GNG5 ENSCATP00000004605 ENSCATP00000004605 KCNJ3 KCNJ3 DDC DDC PPP3CA PPP3CA GNG12 GNG12 GNB1 GNB1 KCNJ5 KCNJ5 LOC105585318 LOC105585318 PPP2CB PPP2CB MAPK8 MAPK8 GRIN2B GRIN2B GNB4 GNB4 KIF5B KIF5B DRD1 DRD1 ATF2 ATF2 ENSCATP00000001050 ENSCATP00000001050 CALY CALY SLC6A3 SLC6A3 CLOCK CLOCK GNG11 GNG11 GNAQ GNAQ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC18A2Solute carrier family 18 member A2. (517 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
KIF5CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (958 aa)
CALML6Calmodulin like 6. (181 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (204 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
ENSCATP00000043586Uncharacterized protein; Belongs to the calmodulin family. (128 aa)
GNAO1G protein subunit alpha o1. (354 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
GNAI2G protein subunit alpha i2. (355 aa)
LOC105578799Uncharacterized protein. (281 aa)
ENSCATP00000040020Uncharacterized protein; Belongs to the calmodulin family. (91 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (586 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ENSCATP00000038494Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (60 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (556 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2745 aa)
ENSCATP00000035075Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ENSCATP00000035073Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (451 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (461 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
CALML4Calmodulin like 4. (193 aa)
PPP1CCSerine/threonine-protein phosphatase. (293 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (605 aa)
ARRB1Arrestin beta 1. (418 aa)
ENSCATP00000033138Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PPP3CCSerine/threonine-protein phosphatase. (438 aa)
CALM1Calmodulin 1. (149 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
GNB2G protein subunit beta 2. (340 aa)
ENSCATP00000032242Uncharacterized protein; Belongs to the calmodulin family. (128 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (902 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
GNASGNAS complex locus. (1028 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (916 aa)
KIF5AKinesin family member 5A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1024 aa)
PPP2R3BEF-hand domain-containing protein. (176 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2568 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1161 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (423 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1150 aa)
ENSCATP00000027386Uncharacterized protein. (109 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
CALM3Calmodulin 3. (149 aa)
ENSCATP00000026030G protein gamma domain-containing protein. (59 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (533 aa)
LOC105601524Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (305 aa)
ARSIArylsulfatase family member I. (569 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (415 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (440 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
MAOBAmine oxidase. (520 aa)
CALM2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
THTyrosine hydroxylase. (549 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GNAI1G protein subunit alpha i1. (330 aa)
ENSCATP00000018990Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2497 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
GNAI3G protein subunit alpha i3. (354 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
ATF4Activating transcription factor 4. (351 aa)
GNALG protein subunit alpha L. (429 aa)
SLC18A1Solute carrier family 18 member A1. (525 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (422 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1937 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2341 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
MAOAAmine oxidase. (527 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
COMTCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (235 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (393 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
GNB3G protein subunit beta 3. (340 aa)
LOC105581531Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PVALEFParvalbumin like EF-hand containing. (133 aa)
GNB5G protein subunit beta 5. (409 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (468 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ARR3Arrestin 3. (388 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (628 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ENSCATP00000004605Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (101 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
DDCDopa decarboxylase. (466 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNB1G protein subunit beta 1. (340 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (432 aa)
LOC105585318Uncharacterized protein. (246 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
GNB4G protein subunit beta 4. (340 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (964 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ENSCATP00000001050G protein gamma domain-containing protein. (63 aa)
CALYCalcyon neuron specific vesicular protein. (217 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (620 aa)
CLOCKClock circadian regulator. (830 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNAQUncharacterized protein. (359 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
Server load: low (16%) [HD]