STRINGSTRING
CYP2J2 CYP2J2 TRPV3 TRPV3 ADCY3 ADCY3 HTR2B HTR2B MAPK8 MAPK8 LOC105585318 LOC105585318 P2RY2 P2RY2 AADAC AADAC PLA2G4C PLA2G4C SRC SRC TRPV4 TRPV4 PRKCH PRKCH NGF NGF MAPK13 MAPK13 CALML3 CALML3 TRPV2 TRPV2 PVALEF PVALEF ADCY7 ADCY7 PLA2G4A PLA2G4A PRKCB PRKCB MAPK11 MAPK11 ASIC3 ASIC3 ALOX12 ALOX12 PLA2G4E PLA2G4E ASIC1 ASIC1 ADCY9 ADCY9 PPP1CA PPP1CA PRKCA PRKCA ADCY6 ADCY6 ASIC5 ASIC5 HTR2C HTR2C PLCB3 PLCB3 MAP2K3 MAP2K3 TRPM8 TRPM8 PLA2G4B PLA2G4B IL1B IL1B KNG1 KNG1 JMJD7 JMJD7 PTRHD1 PTRHD1 MAPK9 MAPK9 CALM2 CALM2 PLCG2 PLCG2 ADCY2 ADCY2 CAMK2B CAMK2B MAPK12 MAPK12 ADCY8 ADCY8 PRKCG PRKCG PRKCQ PRKCQ PLCG1 PLCG1 PLA2G6 PLA2G6 ASIC4 ASIC4 PRKCD PRKCD LOC105581754 LOC105581754 CAMK2A CAMK2A ARSI ARSI PIK3R2 PIK3R2 ASIC2 ASIC2 PIK3CB PIK3CB CYP4B1 CYP4B1 CAMK2D CAMK2D AADACL2 AADACL2 CALM3 CALM3 PLA2G4F PLA2G4F ADCY5 ADCY5 PLCB4 PLCB4 PIK3CA PIK3CA PIK3R3 PIK3R3 HTR2A HTR2A PLCB2 PLCB2 PIK3R1 PIK3R1 PPP1CB PPP1CB LOC105571706 LOC105571706 ITPR3 ITPR3 ITPR2 ITPR2 GNAS GNAS ENSCATP00000032242 ENSCATP00000032242 CALM1 CALM1 PTGER2 PTGER2 IL1RAP IL1RAP PPP1CC PPP1CC BDKRB1 BDKRB1 CALML4 CALML4 ADCY4 ADCY4 PLA2G4D PLA2G4D PRKCE PRKCE ENSCATP00000036069 ENSCATP00000036069 ITPR1 ITPR1 CAMK2G CAMK2G TRPV1 TRPV1 PIK3CD PIK3CD MAPK14 MAPK14 PRKACB PRKACB TRPA1 TRPA1 CYP2W1 CYP2W1 ENSCATP00000040020 ENSCATP00000040020 IGF1 IGF1 NTRK1 NTRK1 MAPK10 MAPK10 IL1R1 IL1R1 PTGER4 PTGER4 MAP2K6 MAP2K6 ENSCATP00000043586 ENSCATP00000043586 PRKACA PRKACA BDKRB2 BDKRB2 CALML6 CALML6 PLCB1 PLCB1 ADCY1 ADCY1 GNAQ GNAQ HRH1 HRH1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CYP2J2Cytochrome P450 family 2 subfamily J member 2; Belongs to the cytochrome P450 family. (502 aa)
TRPV3Transient receptor potential cation channel subfamily V member 3; Belongs to the transient receptor (TC 1.A.4) family. (790 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
LOC105585318Uncharacterized protein. (246 aa)
P2RY2Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. (377 aa)
AADACArylacetamide deacetylase. (399 aa)
PLA2G4CPhospholipase A2 group IVC. (531 aa)
SRCTyrosine-protein kinase. (644 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (309 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (760 aa)
PVALEFParvalbumin like EF-hand containing. (133 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1114 aa)
PLA2G4APhospholipase A2. (749 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
ASIC3Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (541 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
PLA2G4EPhospholipase A2. (869 aa)
ASIC1Acid sensing ion channel subunit 1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (562 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1372 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
ASIC5Acid sensing ion channel subunit family member 5; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (505 aa)
HTR2C5-hydroxytryptamine receptor 2C. (458 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
TRPM8Transient receptor potential cation channel subfamily M member 8. (1115 aa)
PLA2G4BPhospholipase A2. (781 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
KNG1Kininogen 1. (644 aa)
JMJD7Jumonji domain containing 7. (316 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (139 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CALM2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1236 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
PLA2G6Phospholipase A2 group VI. (784 aa)
ASIC4Acid sensing ion channel subunit family member 4; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (666 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
LOC105581754Uncharacterized protein; Belongs to the cytochrome P450 family. (489 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
ARSIArylsulfatase family member I. (569 aa)
PIK3R2Uncharacterized protein. (624 aa)
ASIC2Acid sensing ion channel subunit 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (512 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
CYP4B1Cytochrome P450 family 4 subfamily B member 1; Belongs to the cytochrome P450 family. (511 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (533 aa)
AADACL2Arylacetamide deacetylase like 2. (401 aa)
CALM3Calmodulin 3. (149 aa)
PLA2G4FPhospholipase A2. (849 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1161 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
LOC105571706Uncharacterized protein. (455 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2568 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
GNASGNAS complex locus. (1028 aa)
ENSCATP00000032242Uncharacterized protein; Belongs to the calmodulin family. (128 aa)
CALM1Calmodulin 1. (149 aa)
PTGER2Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (358 aa)
IL1RAPInterleukin 1 receptor accessory protein. (687 aa)
PPP1CCSerine/threonine-protein phosphatase. (293 aa)
BDKRB1Bradykinin receptor B1. (282 aa)
CALML4Calmodulin like 4. (193 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
PLA2G4DPhospholipase A2. (817 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
ENSCATP00000036069Uncharacterized protein. (416 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2745 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (556 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (847 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1144 aa)
CYP2W1Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family. (512 aa)
ENSCATP00000040020Uncharacterized protein; Belongs to the calmodulin family. (91 aa)
IGF1Insulin like growth factor 1. (208 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (490 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
ENSCATP00000043586Uncharacterized protein; Belongs to the calmodulin family. (128 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (391 aa)
CALML6Calmodulin like 6. (181 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1115 aa)
GNAQUncharacterized protein. (359 aa)
HRH1Histamine receptor H1; Belongs to the G-protein coupled receptor 1 family. (487 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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