STRINGSTRING
FLOT1 FLOT1 GRB2 GRB2 KIAA1671 KIAA1671 MAPK10 MAPK10 SHC3 SHC3 PTPRS PTPRS PYGL PYGL PRKAG3 PRKAG3 ENSCATP00000040020 ENSCATP00000040020 PTPRF PTPRF PRKAG2 PRKAG2 MKNK2 MKNK2 MYO9B MYO9B SOS2 SOS2 PRKACB PRKACB CRK CRK PIK3CD PIK3CD CRYBB3 CRYBB3 MKNK1 MKNK1 ENSCATP00000037667 ENSCATP00000037667 SREBF1 SREBF1 REM1 REM1 NRAS NRAS ALKBH4 ALKBH4 PRKAA2 PRKAA2 PHKG2 PHKG2 MTOR MTOR PRKAR2A PRKAR2A LIPE LIPE PPP1R3C PPP1R3C BMT2 BMT2 SLC2A4 SLC2A4 FBP1 FBP1 PTPN1 PTPN1 G6PC3 G6PC3 CALML4 CALML4 PPP1CC PPP1CC SHC4 SHC4 CRKL CRKL PRKAA1 PRKAA1 CALM1 CALM1 ENSCATP00000032242 ENSCATP00000032242 TRIP10 TRIP10 AKT2 AKT2 PYGB PYGB ENSCATP00000031901 ENSCATP00000031901 INPPL1 INPPL1 ACACB ACACB ENSCATP00000030673 ENSCATP00000030673 HK3 HK3 PPP1R14B PPP1R14B GCK GCK PDE3B PDE3B MAP2K1 MAP2K1 RHEBL1 RHEBL1 PCK2 PCK2 TSC2 TSC2 IRS2 IRS2 TMEM145 TMEM145 SORBS3 SORBS3 PPP1CB PPP1CB SORBS1 SORBS1 PIK3R1 PIK3R1 EIF4E EIF4E EXOC7 EXOC7 PIK3R3 PIK3R3 CSDE1 CSDE1 SHC1 SHC1 PIK3CA PIK3CA RHEB RHEB SREBF2 SREBF2 FOXO1 FOXO1 CALM3 CALM3 EIF4E1B EIF4E1B IRS4 IRS4 FASN FASN PRKCZ PRKCZ ACACA ACACA SH2B2 SH2B2 RAF1 RAF1 ELK3 ELK3 INPP5A INPP5A LOC105585293 LOC105585293 PIK3CB PIK3CB PIK3R2 PIK3R2 ENSCATP00000023911 ENSCATP00000023911 EIF4E2 EIF4E2 PRKAG1 PRKAG1 PYGM PYGM RPS6 RPS6 EFCAB3 EFCAB3 GSK3B GSK3B RHOQ RHOQ RRAD RRAD PKLR PKLR BRAF BRAF HK2 HK2 TBCA TBCA PHKA1 PHKA1 CALM2 CALM2 LOC105575034 LOC105575034 MAPK9 MAPK9 AKT3 AKT3 LOC105572981 LOC105572981 FBP2 FBP2 IKBKB IKBKB BAD BAD PDPK1 PDPK1 PRKCI PRKCI GEM GEM ENSCATP00000017894 ENSCATP00000017894 TSC1 TSC1 ENSCATP00000017436 ENSCATP00000017436 PPARGC1A PPARGC1A SH2B1 SH2B1 ELK1 ELK1 FLOT2 FLOT2 MAPK1 MAPK1 PPP1R3F PPP1R3F PHKB PHKB ENSCATP00000014838 ENSCATP00000014838 HRAS HRAS PPP1CA PPP1CA RPS6KB2 RPS6KB2 MAP2K2 MAP2K2 SORBS2 SORBS2 PRKAR1A PRKAR1A ARAF ARAF PHKA2 PHKA2 PHKG1 PHKG1 IRS1 IRS1 KRAS KRAS MAPK3 MAPK3 PRKAB1 PRKAB1 ENSCATP00000010452 ENSCATP00000010452 RPS6KB1 RPS6KB1 RAPGEF1 RAPGEF1 BUD23 BUD23 INSR INSR ENSCATP00000007662 ENSCATP00000007662 SOCS4 SOCS4 ENSCATP00000007407 ENSCATP00000007407 PVALEF PVALEF PCK1 PCK1 RPTOR RPTOR ENSCATP00000006855 ENSCATP00000006855 CALML3 CALML3 AKT1 AKT1 PPP1R3A PPP1R3A PPP1R3D PPP1R3D PPP1R3E PPP1R3E PPP1R3B PPP1R3B ENSCATP00000004894 ENSCATP00000004894 CRYGN CRYGN ERAS ERAS SOS1 SOS1 CEP152 CEP152 GYS1 GYS1 SOCS2 SOCS2 PTPRD PTPRD SOCS1 SOCS1 MAPK8 MAPK8 CBLB CBLB G6PC G6PC SOCS3 SOCS3 ENSCATP00000000152 ENSCATP00000000152 CBL CBL PRKAR1B PRKAR1B HK1 HK1 EFCAB13 EFCAB13 CALML6 CALML6 MYO9A MYO9A HKDC1 HKDC1 PRKAB2 PRKAB2 GYS2 GYS2 INS INS EIF4EBP1 EIF4EBP1 PRKACA PRKACA ENSCATP00000043586 ENSCATP00000043586 PRKAR2B PRKAR2B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
KIAA1671KIAA1671. (1802 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
SHC3SHC adaptor protein 3. (598 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1948 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (847 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
ENSCATP00000040020Uncharacterized protein; Belongs to the calmodulin family. (91 aa)
PTPRFProtein tyrosine phosphatase receptor type F. (1963 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (465 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2157 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1327 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CRYBB3Crystallin beta B3; Belongs to the beta/gamma-crystallin family. (211 aa)
MKNK1MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (476 aa)
ENSCATP00000037667Protein kinase domain-containing protein. (365 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ALKBH4AlkB homolog 4, lysine demethylase. (302 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PHKG2Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (410 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (404 aa)
LIPELipase E, hormone sensitive type. (1051 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (522 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
CALML4Calmodulin like 4. (193 aa)
PPP1CCSerine/threonine-protein phosphatase. (293 aa)
SHC4SHC adaptor protein 4. (630 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
CALM1Calmodulin 1. (149 aa)
ENSCATP00000032242Uncharacterized protein; Belongs to the calmodulin family. (128 aa)
TRIP10Thyroid hormone receptor interactor 10. (601 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
ENSCATP0000003190140S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (224 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1258 aa)
ACACBAcetyl-CoA carboxylase beta. (2458 aa)
ENSCATP00000030673Uncharacterized protein. (652 aa)
HK3Hexokinase 3. (960 aa)
PPP1R14BUncharacterized protein. (207 aa)
GCKPhosphotransferase. (480 aa)
PDE3BPhosphodiesterase. (1117 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (344 aa)
RHEBL1RHEB like 1. (187 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (645 aa)
TSC2TSC complex subunit 2. (1807 aa)
IRS2Insulin receptor substrate 2. (1338 aa)
TMEM145Transmembrane protein 145. (563 aa)
SORBS3Sorbin and SH3 domain containing 3. (671 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
SORBS1Sorbin and SH3 domain containing 1. (1295 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
EIF4EEukaryotic translation initiation factor 4E. (247 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (707 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
CSDE1Cold shock domain containing E1. (844 aa)
SHC1SHC adaptor protein 1. (584 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
RHEBRas homolog, mTORC1 binding. (196 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1146 aa)
FOXO1Forkhead box O1. (655 aa)
CALM3Calmodulin 3. (149 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (244 aa)
IRS4Insulin receptor substrate 4. (1222 aa)
FASNFatty acid synthase. (2511 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
ACACAAcetyl-CoA carboxylase alpha. (2389 aa)
SH2B2SH2B adaptor protein 2. (678 aa)
RAF1Uncharacterized protein. (668 aa)
ELK3ETS transcription factor ELK3. (407 aa)
INPP5AInositol polyphosphate-5-phosphatase A. (412 aa)
LOC105585293Uncharacterized protein. (290 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
PIK3R2Uncharacterized protein. (624 aa)
ENSCATP00000023911Uncharacterized protein. (368 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (249 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (333 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
EFCAB3EF-hand calcium binding domain 3. (470 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (440 aa)
RHOQRas homolog family member Q. (211 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (762 aa)
HK2Hexokinase 2. (917 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (131 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1240 aa)
CALM2Calmodulin 1; Belongs to the calmodulin family. (149 aa)
LOC10557503440S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (243 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC105572981Uncharacterized protein. (132 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (339 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
BADBCL2 associated agonist of cell death. (167 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (534 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
ENSCATP0000001789440S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (204 aa)
TSC1TSC complex subunit 1. (1167 aa)
ENSCATP00000017436ETS domain-containing protein. (394 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
SH2B1SH2B adaptor protein 1. (756 aa)
ELK1ETS domain-containing protein. (428 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (505 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PPP1R3FProtein phosphatase 1 regulatory subunit 3F. (733 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1093 aa)
ENSCATP00000014838ETS domain-containing protein. (418 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (497 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
SORBS2Sorbin and SH3 domain containing 2. (1191 aa)
PRKAR1AUncharacterized protein. (381 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1235 aa)
PHKG1Phosphorylase kinase catalytic subunit gamma 1; Belongs to the protein kinase superfamily. (421 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
ENSCATP00000010452Uncharacterized protein. (596 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1303 aa)
BUD23BUD23 rRNA methyltransferase and ribosome maturation factor. (297 aa)
INSRTyrosine-protein kinase receptor. (1339 aa)
ENSCATP00000007662Tubulin-specific chaperone A; Belongs to the TBCA family. (108 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
ENSCATP00000007407PID domain-containing protein. (502 aa)
PVALEFParvalbumin like EF-hand containing. (133 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1314 aa)
ENSCATP00000006855Uncharacterized protein. (519 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1145 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (299 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (279 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (285 aa)
ENSCATP00000004894ETS domain-containing protein. (421 aa)
CRYGNCrystallin gamma N; Belongs to the beta/gamma-crystallin family. (182 aa)
ERASES cell expressed Ras. (233 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
CEP152Centrosomal protein 152. (1706 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
SOCS2Suppressor of cytokine signaling 2. (202 aa)
PTPRDProtein tyrosine phosphatase receptor type D. (1749 aa)
SOCS1Suppressor of cytokine signaling 1. (213 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
CBLBCbl proto-oncogene B. (1027 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
ENSCATP00000000152Uncharacterized protein. (64 aa)
CBLCbl proto-oncogene. (907 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (381 aa)
HK1Hexokinase 1. (921 aa)
EFCAB13EF-hand calcium binding domain 13. (972 aa)
CALML6Calmodulin like 6. (181 aa)
MYO9AMyosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2626 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
ENSCATP00000043586Uncharacterized protein; Belongs to the calmodulin family. (128 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (421 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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