STRINGSTRING
PIK3R1 PIK3R1 ENSCATP00000000012 ENSCATP00000000012 GNG11 GNG11 ADCY1 ADCY1 ENSCATP00000001050 ENSCATP00000001050 ADCY4 ADCY4 SMAD2 SMAD2 ATF2 ATF2 ADCY3 ADCY3 GNB4 GNB4 MAPK8 MAPK8 MAP2K7 MAP2K7 LOC105585318 LOC105585318 GNB1 GNB1 GNG12 GNG12 CEP152 CEP152 MMP2 MMP2 SOS1 SOS1 SRC SRC ERAS ERAS ENSCATP00000004605 ENSCATP00000004605 GNG5 GNG5 ARR3 ARR3 RXFP4 RXFP4 AKT1 AKT1 MAPK13 MAPK13 ENSCATP00000006855 ENSCATP00000006855 GNB5 GNB5 ENSCATP00000007407 ENSCATP00000007407 ADCY7 ADCY7 LOC105581531 LOC105581531 COL4A4 COL4A4 GNB3 GNB3 COL1A1 COL1A1 TGFB1 TGFB1 MAPK11 MAPK11 INSL5 INSL5 ENSCATP00000010452 ENSCATP00000010452 TGFBR1 TGFBR1 FBXO21 FBXO21 MMP9 MMP9 EDNRB EDNRB CREB3L4 CREB3L4 MAPK3 MAPK3 KRAS KRAS VEGFA VEGFA ATF4 ATF4 ADCY9 ADCY9 ATF6B ATF6B EDN1 EDN1 MAP2K2 MAP2K2 GNAI3 GNAI3 INSL3 INSL3 PRKCA PRKCA HRAS HRAS COL4A1 COL4A1 VEGFB VEGFB COL3A1 COL3A1 ADCY6 ADCY6 MFF MFF MAPK1 MAPK1 PLCB3 PLCB3 COL1A2 COL1A2 COL4A2 COL4A2 GNG13 GNG13 ENSCATP00000018990 ENSCATP00000018990 GNAI1 GNAI1 AKT3 AKT3 PTRHD1 PTRHD1 MAPK9 MAPK9 ADCY2 ADCY2 VEGFD VEGFD MAPK12 MAPK12 ADCY8 ADCY8 CREB3L2 CREB3L2 GNGT1 GNGT1 COL4A3 COL4A3 NOS2 NOS2 PIK3R2 PIK3R2 PIK3CB PIK3CB LOC105585293 LOC105585293 RAF1 RAF1 CREB3L1 CREB3L1 LOC105601524 LOC105601524 PRKCZ PRKCZ ENSCATP00000026030 ENSCATP00000026030 ADCY5 ADCY5 PLCB4 PLCB4 PIK3CA PIK3CA SHC1 SHC1 CSDE1 CSDE1 PIK3R3 PIK3R3 CREB1 CREB1 PLCB2 PLCB2 MMP13 MMP13 ACTA2 ACTA2 CREB3 CREB3 GNG4 GNG4 MAP2K1 MAP2K1 NOS1 NOS1 GNG8 GNG8 GNG3 GNG3 RLN2 RLN2 GNAS GNAS AKT2 AKT2 GNG2 GNG2 GNB2 GNB2 CREB5 CREB5 COL4A6 COL4A6 WDR78 WDR78 ENSCATP00000033138 ENSCATP00000033138 ARRB1 ARRB1 EGFR EGFR SHC4 SHC4 TGFBR2 TGFBR2 GNGT2 GNGT2 CREB3L3 CREB3L3 ENSCATP00000035075 ENSCATP00000035075 NOS3 NOS3 RLN3 RLN3 VEGFC VEGFC RELA RELA NRAS NRAS NFKBIA NFKBIA MAP2K4 MAP2K4 ENSCATP00000037667 ENSCATP00000037667 PIK3CD PIK3CD ENSCATP00000038494 ENSCATP00000038494 MAPK14 MAPK14 PRKACB PRKACB SOS2 SOS2 RXFP1 RXFP1 SHC3 SHC3 GNAI2 GNAI2 MAPK10 MAPK10 GRB2 GRB2 MMP1 MMP1 GNAO1 GNAO1 PRKACA PRKACA FOS FOS GNA15 GNA15 NFKB1 NFKB1 PLCB1 PLCB1 RXFP2 RXFP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ENSCATP00000000012Protein kinase domain-containing protein. (231 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1115 aa)
ENSCATP00000001050G protein gamma domain-containing protein. (63 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
GNB4G protein subunit beta 4. (340 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (517 aa)
LOC105585318Uncharacterized protein. (246 aa)
GNB1G protein subunit beta 1. (340 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
CEP152Centrosomal protein 152. (1706 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
SRCTyrosine-protein kinase. (644 aa)
ERASES cell expressed Ras. (233 aa)
ENSCATP00000004605Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (101 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ARR3Arrestin 3. (388 aa)
RXFP4Relaxin family peptide/INSL5 receptor 4. (373 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
ENSCATP00000006855Uncharacterized protein. (519 aa)
GNB5G protein subunit beta 5. (409 aa)
ENSCATP00000007407PID domain-containing protein. (502 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1114 aa)
LOC105581531Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
COL4A4Collagen type IV alpha 4 chain. (1692 aa)
GNB3G protein subunit beta 3. (340 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
INSL5Insulin like 5. (135 aa)
ENSCATP00000010452Uncharacterized protein. (596 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
FBXO21F-box protein 21. (628 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (507 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (422 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (409 aa)
ATF4Activating transcription factor 4. (351 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1372 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
EDN1Endothelin 1. (211 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
GNAI3G protein subunit alpha i3. (354 aa)
INSL3Insulin like 3. (147 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (188 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
MFFMitochondrial fission factor. (385 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
COL4A2Collagen type IV alpha 2 chain. (1724 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
ENSCATP00000018990Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNAI1G protein subunit alpha i1. (330 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (139 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
COL4A3Collagen type IV alpha 3 chain. (1670 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1152 aa)
PIK3R2Uncharacterized protein. (624 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
LOC105585293Uncharacterized protein. (290 aa)
RAF1Uncharacterized protein. (668 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
LOC105601524Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
ENSCATP00000026030G protein gamma domain-containing protein. (59 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
SHC1SHC adaptor protein 1. (584 aa)
CSDE1Cold shock domain containing E1. (844 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1161 aa)
MMP13Matrix metallopeptidase 13. (501 aa)
ACTA2Actin alpha 2, smooth muscle. (377 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (344 aa)
NOS1Nitric oxide synthase 1. (1461 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
RLN2Relaxin 2. (185 aa)
GNASGNAS complex locus. (1028 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
GNB2G protein subunit beta 2. (340 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
WDR78WD repeat domain 78. (847 aa)
ENSCATP00000033138Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ARRB1Arrestin beta 1. (418 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
SHC4SHC adaptor protein 4. (630 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (461 aa)
ENSCATP00000035075Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
RLN3Relaxin 3. (166 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (421 aa)
RELARELA proto-oncogene, NF-kB subunit. (550 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (416 aa)
ENSCATP00000037667Protein kinase domain-containing protein. (365 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ENSCATP00000038494Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (60 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1327 aa)
RXFP1Relaxin family peptide receptor 1. (779 aa)
SHC3SHC adaptor protein 3. (598 aa)
GNAI2G protein subunit alpha i2. (355 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MMP1Matrix metallopeptidase 1. (469 aa)
GNAO1G protein subunit alpha o1. (354 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
GNA15G protein subunit alpha 15. (374 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
RXFP2Relaxin family peptide receptor 2. (753 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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