STRINGSTRING
KCNJ11 KCNJ11 INSR INSR CACNA1D CACNA1D PARP8 PARP8 MAPK3 MAPK3 IRS1 IRS1 ABCC8 ABCC8 MAPK1 MAPK1 CACNA1A CACNA1A IKBKB IKBKB MAPK9 MAPK9 HK2 HK2 PKLR PKLR PRKCD PRKCD PIK3R2 PIK3R2 PIK3CB PIK3CB SLC2A2 SLC2A2 PDX1 PDX1 CACNA1E CACNA1E PRKCZ PRKCZ IRS4 IRS4 PIK3CA PIK3CA PIK3R3 PIK3R3 PIK3R1 PIK3R1 IRS2 IRS2 PKM PKM GCK GCK HK3 HK3 CACNA1G CACNA1G SLC2A4 SLC2A4 MTOR MTOR PRKCE PRKCE PIK3CD PIK3CD ADIPOQ ADIPOQ MAPK10 MAPK10 CACNA1C CACNA1C INS INS PARP6 PARP6 HKDC1 HKDC1 HK1 HK1 SOCS3 SOCS3 TNF TNF TNIK TNIK LOC105583754 LOC105583754 MAPK8 MAPK8 SOCS1 SOCS1 SOCS2 SOCS2 ENSCATP00000003151 ENSCATP00000003151 ENSCATP00000005880 ENSCATP00000005880 CACNA1B CACNA1B SOCS4 SOCS4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
INSRTyrosine-protein kinase receptor. (1339 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
PARP8Poly [ADP-ribose] polymerase. (894 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
ABCC8ATP binding cassette subfamily C member 8. (1582 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2497 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
HK2Hexokinase 2. (917 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PIK3R2Uncharacterized protein. (624 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
PDX1Pancreatic and duodenal homeobox 1. (283 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2315 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
IRS4Insulin receptor substrate 4. (1222 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
IRS2Insulin receptor substrate 2. (1338 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (556 aa)
GCKPhosphotransferase. (480 aa)
HK3Hexokinase 3. (960 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2377 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (522 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (274 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
PARP6Poly [ADP-ribose] polymerase. (631 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
HK1Hexokinase 1. (921 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TNIKTRAF2 and NCK interacting kinase. (1359 aa)
LOC105583754Pyruvate kinase; Belongs to the pyruvate kinase family. (469 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
SOCS1Suppressor of cytokine signaling 1. (213 aa)
SOCS2Suppressor of cytokine signaling 2. (202 aa)
ENSCATP00000003151Pyruvate kinase; Belongs to the pyruvate kinase family. (510 aa)
ENSCATP00000005880Pyruvate kinase; Belongs to the pyruvate kinase family. (490 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2341 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.