STRINGSTRING
PRKAB2 PRKAB2 ENSCATP00000000560 ENSCATP00000000560 SOCS3 SOCS3 TNF TNF G6PC G6PC TNIK TNIK CD36 CD36 SLC27A6 SLC27A6 MAPK8 MAPK8 SLC27A4 SLC27A4 SLC27A5 SLC27A5 GYS1 GYS1 TPTE2 TPTE2 CPT1A CPT1A RPS6KA6 RPS6KA6 PPP1R3B PPP1R3B PPP1R3E PPP1R3E ENSCATP00000005869 ENSCATP00000005869 PPP1R3D PPP1R3D PPP1R3A PPP1R3A TBC1D4 TBC1D4 MLXIP MLXIP MLX MLX AKT1 AKT1 PCK1 PCK1 INSR INSR PRKCB PRKCB RPS6KB1 RPS6KB1 PRKAB1 PRKAB1 CREB3L4 CREB3L4 IRS1 IRS1 PPARGC1B PPARGC1B RPS6KA2 RPS6KA2 MLXIPL MLXIPL PTEN PTEN RPS6KB2 RPS6KB2 PPP1CA PPP1CA NR1H3 NR1H3 SLC2A1 SLC2A1 RPS6KA1 RPS6KA1 STAT3 STAT3 PPARGC1A PPARGC1A OGA OGA PDPK1 PDPK1 IKBKB IKBKB PTPA PTPA NR1H2 NR1H2 SLC27A1 SLC27A1 AKT3 AKT3 PTPN11 PTPN11 MAPK9 MAPK9 GFPT2 GFPT2 TNFRSF1A TNFRSF1A CREB3L2 CREB3L2 GSK3B GSK3B PRKCQ PRKCQ PRKCD PRKCD PYGM PYGM PRKAG1 PRKAG1 PIK3R2 PIK3R2 PIK3CB PIK3CB SLC2A2 SLC2A2 CPT1B CPT1B TRIB3 TRIB3 CREB3L1 CREB3L1 RPS6KA3 RPS6KA3 PRKCZ PRKCZ FOXO1 FOXO1 AGT AGT PIK3CA PIK3CA PIK3R3 PIK3R3 CREB1 CREB1 PIK3R1 PIK3R1 CRTC2 CRTC2 PPP1CB PPP1CB PPARA PPARA NFU1 NFU1 IRS2 IRS2 PCK2 PCK2 SLC27A2 SLC27A2 CREB3 CREB3 ACACB ACACB PYGB PYGB AKT2 AKT2 CREB5 CREB5 PRKAA1 PRKAA1 PPP1CC PPP1CC G6PC3 G6PC3 GFPT1 GFPT1 CREB3L3 CREB3L3 PTPN1 PTPN1 NOS3 NOS3 SLC2A4 SLC2A4 PPP1R3C PPP1R3C MTOR MTOR PRKCE PRKCE PRKAA2 PRKAA2 RELA RELA NFKBIA NFKBIA IL6 IL6 SREBF1 SREBF1 PIK3CD PIK3CD PRKAG2 PRKAG2 PTPRF PTPRF PRKAG3 PRKAG3 PYGL PYGL PTPRS PTPRS OGT OGT MAPK10 MAPK10 INS INS GYS2 GYS2 ENSCATP00000044421 ENSCATP00000044421 SLC27A3 SLC27A3 NFKB1 NFKB1 ENSCATP00000045954 ENSCATP00000045954
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
ENSCATP00000000560C2 tensin-type domain-containing protein. (165 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
TNIKTRAF2 and NCK interacting kinase. (1359 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
SLC27A6Solute carrier family 27 member 6. (619 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
SLC27A4Solute carrier family 27 member 4. (649 aa)
SLC27A5Solute carrier family 27 member 5. (690 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
TPTE2Uncharacterized protein. (550 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
RPS6KA6Ribosomal protein S6 kinase. (745 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (285 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (279 aa)
ENSCATP00000005869Uncharacterized protein. (526 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (299 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1145 aa)
TBC1D4TBC1 domain family member 4. (1298 aa)
MLXIPMLX interacting protein. (919 aa)
MLXMAX dimerization protein MLX. (298 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
INSRTyrosine-protein kinase receptor. (1339 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (422 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
PPARGC1BPPARG coactivator 1 beta. (1019 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
MLXIPLMLX interacting protein like. (880 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (497 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (466 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (504 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
STAT3Signal transducer and activator of transcription. (777 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
OGAO-GlcNAcase. (900 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (534 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
PTPASerine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (358 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (461 aa)
SLC27A1Solute carrier family 27 member 1. (646 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PTPN11Protein tyrosine phosphatase non-receptor type 11. (552 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
GFPT2Glutamine-fructose-6-phosphate transaminase 2. (682 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (440 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (333 aa)
PIK3R2Uncharacterized protein. (624 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
TRIB3Tribbles pseudokinase 3. (385 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
RPS6KA3Ribosomal protein S6 kinase. (732 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
FOXO1Forkhead box O1. (655 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CRTC2CREB regulated transcription coactivator 2. (694 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
PPARAPeroxisome proliferator activated receptor alpha. (511 aa)
NFU1NFU1 iron-sulfur cluster scaffold. (230 aa)
IRS2Insulin receptor substrate 2. (1338 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (645 aa)
SLC27A2Solute carrier family 27 member 2. (620 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
ACACBAcetyl-CoA carboxylase beta. (2458 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
PPP1CCSerine/threonine-protein phosphatase. (293 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
GFPT1Glutamine--fructose-6-phosphate transaminase 1. (669 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (461 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (522 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
RELARELA proto-oncogene, NF-kB subunit. (550 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (214 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa)
PTPRFProtein tyrosine phosphatase receptor type F. (1963 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (847 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1948 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
ENSCATP00000044421Uncharacterized protein. (441 aa)
SLC27A3Solute carrier family 27 member 3. (796 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
ENSCATP00000045954Nfu_N domain-containing protein. (232 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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