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SHC3 SHC3 CACNA1C CACNA1C PRKACA PRKACA FOS FOS PLCB1 PLCB1 EP300 EP300 GNAI2 GNAI2 MAPK10 MAPK10 GRB2 GRB2 GHSR GHSR MAP2K6 MAP2K6 SOCS3 SOCS3 ADCY1 ADCY1 GNAQ GNAQ ENSCATP00000000012 ENSCATP00000000012 SOS2 SOS2 PRKACB PRKACB CACNA1S CACNA1S MAPK14 MAPK14 CRK CRK PIK3CD PIK3CD ENSCATP00000037667 ENSCATP00000037667 MAP2K4 MAP2K4 ITPR1 ITPR1 MAP3K1 MAP3K1 NRAS NRAS MTOR MTOR CREB3L3 CREB3L3 SHC4 SHC4 LOC105590745 LOC105590745 CRKL CRKL CREBBP CREBBP STAT1 STAT1 CREB5 CREB5 AKT2 AKT2 GNAS GNAS STAT5A STAT5A ADCY10 ADCY10 IGFALS IGFALS GNA11 GNA11 BCAR1 BCAR1 MAP2K1 MAP2K1 CREB3 CREB3 ITPR2 ITPR2 ITPR3 ITPR3 IRS2 IRS2 PIK3R1 PIK3R1 PLCB2 PLCB2 CREB1 CREB1 PIK3R3 PIK3R3 CSDE1 CSDE1 SHC1 SHC1 PIK3CA PIK3CA PLCB4 PLCB4 ADCY5 ADCY5 IRS4 IRS4 CREB3L1 CREB3L1 RAF1 RAF1 LOC105585293 LOC105585293 PIK3CB PIK3CB PIK3R2 PIK3R2 PLCG1 PLCG1 GSK3B GSK3B CREB3L2 CREB3L2 PRKCG PRKCG ADCY8 ADCY8 MAPK12 MAPK12 ADCY2 ADCY2 PLCG2 PLCG2 POU1F1 POU1F1 MAPK9 MAPK9 PTRHD1 PTRHD1 AKT3 AKT3 GNAI1 GNAI1 SSTR5 SSTR5 STAT3 STAT3 LOC105590746-2 LOC105590746-2 MAP2K3 MAP2K3 PLCB3 PLCB3 MAPK1 MAPK1 ADCY6 ADCY6 HRAS HRAS PRKCA PRKCA GNAI3 GNAI3 MAP2K2 MAP2K2 ATF6B ATF6B ADCY9 ADCY9 ATF4 ATF4 IRS1 IRS1 KRAS KRAS MAPK3 MAPK3 CREB3L4 CREB3L4 GHRL GHRL ENSCATP00000010452 ENSCATP00000010452 CACNA1D CACNA1D MAPK11 MAPK11 GHR GHR PRKCB PRKCB JAK2 JAK2 CACNA1F CACNA1F ADCY7 ADCY7 ENSCATP00000007407 ENSCATP00000007407 JUNB JUNB SSTR1 SSTR1 ENSCATP00000006855 ENSCATP00000006855 MAPK13 MAPK13 AKT1 AKT1 SSTR3 SSTR3 SSTR2 SSTR2 PTK2 PTK2 IGFBP3 IGFBP3 ERAS ERAS SOS1 SOS1 CEP152 CEP152 SOCS2 SOCS2 LOC105585318 LOC105585318 STAT5B STAT5B SOCS1 SOCS1 MAPK8 MAPK8 LOC105590746 LOC105590746 ADCY3 ADCY3 ATF2 ATF2 ADCY4 ADCY4 GHRH GHRH GHRHR GHRHR SST SST IGF1 IGF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SHC3SHC adaptor protein 3. (598 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
EP300E1A binding protein p300. (2411 aa)
GNAI2G protein subunit alpha i2. (355 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1115 aa)
GNAQUncharacterized protein. (359 aa)
ENSCATP00000000012Protein kinase domain-containing protein. (231 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1327 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ENSCATP00000037667Protein kinase domain-containing protein. (365 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (416 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2745 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1508 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (461 aa)
SHC4SHC adaptor protein 4. (630 aa)
LOC105590745Uncharacterized protein. (217 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
CREBBPCREB binding protein. (2442 aa)
STAT1Signal transducer and activator of transcription. (780 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
GNASGNAS complex locus. (1028 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
ADCY10Adenylate cyclase 10. (1609 aa)
IGFALSInsulin like growth factor binding protein acid labile subunit. (605 aa)
GNA11G protein subunit alpha 11. (394 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (344 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2568 aa)
IRS2Insulin receptor substrate 2. (1338 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1161 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
CSDE1Cold shock domain containing E1. (844 aa)
SHC1SHC adaptor protein 1. (584 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
ADCY5Adenylate cyclase 5. (1263 aa)
IRS4Insulin receptor substrate 4. (1222 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
RAF1Uncharacterized protein. (668 aa)
LOC105585293Uncharacterized protein. (290 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
PIK3R2Uncharacterized protein. (624 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (440 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1236 aa)
POU1F1POU domain protein. (312 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (139 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GNAI1G protein subunit alpha i1. (330 aa)
SSTR5Somatostatin receptor 5; Belongs to the G-protein coupled receptor 1 family. (223 aa)
STAT3Signal transducer and activator of transcription. (777 aa)
LOC105590746-2Uncharacterized protein. (217 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
GNAI3G protein subunit alpha i3. (354 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1372 aa)
ATF4Activating transcription factor 4. (351 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (422 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
ENSCATP00000010452Uncharacterized protein. (596 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
GHRGrowth hormone receptor. (655 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
JAK2Tyrosine-protein kinase. (1137 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1960 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1114 aa)
ENSCATP00000007407PID domain-containing protein. (502 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
SSTR1Somatostatin receptor 1; Belongs to the G-protein coupled receptor 1 family. (391 aa)
ENSCATP00000006855Uncharacterized protein. (519 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SSTR3Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. (418 aa)
SSTR2Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1068 aa)
IGFBP3Insulin like growth factor binding protein 3. (291 aa)
ERASES cell expressed Ras. (233 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
CEP152Centrosomal protein 152. (1706 aa)
SOCS2Suppressor of cytokine signaling 2. (202 aa)
LOC105585318Uncharacterized protein. (246 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
SOCS1Suppressor of cytokine signaling 1. (213 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
LOC105590746Uncharacterized protein. (248 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
GHRHGrowth hormone releasing hormone. (108 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (436 aa)
SSTSomatostatin. (116 aa)
IGF1Insulin like growth factor 1. (208 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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