Your Input: | |
| | C3 | Complement C3. (1653 aa) |
| | CASP7 | Caspase 7; Belongs to the peptidase C14A family. (336 aa) |
| | TICAM2 | Toll like receptor adaptor molecule 2. (235 aa) |
| | IRF8 | Interferon regulatory factor 8. (426 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (366 aa) |
| | NLRP3 | NLR family pyrin domain containing 3. (1035 aa) |
| | CASP3 | Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa) |
| | IL23A | Interleukin 23 subunit alpha. (189 aa) |
| | ENSCATP00000011420 | CUB domain-containing protein. (144 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa) |
| | TMED3 | Transmembrane p24 trafficking protein 3. (248 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (271 aa) |
| | RHOC | Ras homolog family member C. (193 aa) |
| | CXCL6 | C-X-C motif chemokine. (123 aa) |
| | EFCAB13 | EF-hand calcium binding domain 13. (972 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | CALML6 | Calmodulin like 6. (181 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | C1RL | Complement C1r subcomponent like; Belongs to the peptidase S1 family. (526 aa) |
| | CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa) |
| | CCDC125 | Coiled-coil domain containing 125. (495 aa) |
| | ENSCATP00000043586 | Uncharacterized protein; Belongs to the calmodulin family. (128 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (721 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (474 aa) |
| | GNAI2 | G protein subunit alpha i2. (355 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa) |
| | IRF3 | Interferon regulatory factor 3. (422 aa) |
| | CALML4 | Calmodulin like 4. (193 aa) |
| | C5 | Complement C5. (1608 aa) |
| | ITGB2 | Integrin beta. (870 aa) |
| | CALM1 | Calmodulin 1. (149 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | ENSCATP00000032242 | Uncharacterized protein; Belongs to the calmodulin family. (128 aa) |
| | C1R | Uncharacterized protein; Belongs to the peptidase S1 family. (719 aa) |
| | ITGB1 | Integrin beta; Belongs to the integrin beta chain family. (801 aa) |
| | NOD1 | Nucleotide binding oligomerization domain containing 1. (953 aa) |
| | TICAM1 | Toll like receptor adaptor molecule 1. (519 aa) |
| | ENSCATP00000026691 | ADF-H domain-containing protein. (126 aa) |
| | CALM3 | Calmodulin 3. (149 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa) |
| | IRF1 | Interferon regulatory factor. (325 aa) |
| | LY96 | Lymphocyte antigen 96. (160 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (328 aa) |
| | LOC105596240 | C-X-C motif chemokine. (114 aa) |
| | C4A | A2M_N_2 domain-containing protein. (1070 aa) |
| | NOS2 | Nitric oxide synthase; Produces nitric oxide (NO). (1152 aa) |
| | TRAF6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa) |
| | CD14 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (374 aa) |
| | GNAI3 | G protein subunit alpha i3. (354 aa) |
| | CASP1 | Caspase 1; Belongs to the peptidase C14A family. (441 aa) |
| | C1QA | Complement C1q A chain. (245 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | C1S | Complement C1s; Belongs to the peptidase S1 family. (697 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa) |
| | C1QB | Complement C1q B chain. (253 aa) |
| | C1QC | Complement C1q C chain. (239 aa) |
| | GNAI1 | G protein subunit alpha i1. (330 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | LOC105572345 | C-type lectin domain-containing protein. (231 aa) |
| | LOC105571657 | ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (187 aa) |
| | CALM2 | Calmodulin 1; Belongs to the calmodulin family. (149 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (367 aa) |
| | TIRAP | TIR domain containing adaptor protein. (239 aa) |
| | CFL1 | Cofilin 1; Belongs to the actin-binding proteins ADF family. (197 aa) |
| | EFCAB3 | EF-hand calcium binding domain 3. (470 aa) |
| | C4BPB | Complement component 4 binding protein beta. (252 aa) |
| | ENSCATP00000040020 | Uncharacterized protein; Belongs to the calmodulin family. (91 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | ENSCATP00000038453 | Uncharacterized protein; Belongs to the peptidase C14A family. (262 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa) |
| | LOC105576878 | SCY domain-containing protein. (114 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (214 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (550 aa) |
| | TMED7 | Transmembrane p24 trafficking protein 7. (224 aa) |
| | TNF | Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa) |
| | LOC105572338 | C-type lectin domain-containing protein. (177 aa) |
| | LOC105576877 | Uncharacterized protein. (592 aa) |
| | ITGA5 | Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1051 aa) |
| | SERPING1 | Serpin family G member 1; Belongs to the serpin family. (534 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (384 aa) |
| | ITGAM | Integrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (365 aa) |
| | CALML3 | Calmodulin like 3; Belongs to the calmodulin family. (149 aa) |
| | PVALEF | Parvalbumin like EF-hand containing. (133 aa) |
| | C4BPA | Complement component 4 binding protein alpha. (597 aa) |
