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| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (721 aa) |
| | LCK | Tyrosine-protein kinase. (540 aa) |
| | NLRC4 | NLR family CARD domain containing 4. (1024 aa) |
| | CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa) |
| | PXN | Paxillin. (1082 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | WAS | WASP actin nucleation promoting factor. (503 aa) |
| | RHOC | Ras homolog family member C. (193 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa) |
| | ENSCATP00000000012 | Protein kinase domain-containing protein. (231 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa) |
| | GNAQ | Uncharacterized protein. (359 aa) |
| | CD8A | CD8a molecule. (276 aa) |
| | ENSCATP00000000811 | Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (337 aa) |
| | LOC105574081 | Ig-like domain-containing protein. (132 aa) |
| | TNF | Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa) |
| | ACTG1 | Actin gamma 1. (377 aa) |
| | ITGA5 | Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1051 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (384 aa) |
| | VAV3 | Vav guanine nucleotide exchange factor 3. (875 aa) |
| | ARHGEF28 | Rho guanine nucleotide exchange factor 28. (1730 aa) |
| | ARF6 | ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (517 aa) |
| | RHOG | Uncharacterized protein. (191 aa) |
| | SRC | Tyrosine-protein kinase. (644 aa) |
| | LCP2 | Lymphocyte cytosolic protein 2. (533 aa) |
| | LOC105571986 | Uncharacterized protein. (189 aa) |
| | SKAP2 | Src kinase associated phosphoprotein 2. (359 aa) |
| | ENSCATP00000004469 | Uncharacterized protein. (191 aa) |
| | RPS6KA6 | Ribosomal protein S6 kinase. (745 aa) |
| | ENSCATP00000005024 | Ig-like domain-containing protein. (150 aa) |
| | PTK2 | Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1068 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | ACTRT1 | Actin related protein T1; Belongs to the actin family. (375 aa) |
| | LOC105574050 | Ig-like domain-containing protein. (138 aa) |
| | IFNB1 | Interferon beta 1. (187 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (365 aa) |
| | ENSCATP00000006715 | Ig-like domain-containing protein. (140 aa) |
| | ENSCATP00000007240 | PIPK domain-containing protein. (467 aa) |
| | ACTL7A | Actin like 7A; Belongs to the actin family. (435 aa) |
| | ACTL7B | Actin like 7B; Belongs to the actin family. (415 aa) |
| | WIPF1 | WAS/WASL interacting protein family member 1. (510 aa) |
| | ELMO2 | Engulfment and cell motility 2. (720 aa) |
| | WASF2 | WASP family member 2. (498 aa) |
| | ENSCATP00000009482 | Ig-like domain-containing protein. (139 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (366 aa) |
| | LOC105577130 | Ig-like domain-containing protein. (133 aa) |
| | NLRP3 | NLR family pyrin domain containing 3. (1035 aa) |
| | NFATC1 | Nuclear factor of activated T cells 1. (973 aa) |
| | ITGA4 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa) |
| | RAC3 | Rac family small GTPase 3. (205 aa) |
| | LOC105575920 | Ig-like domain-containing protein. (140 aa) |
| | ENSCATP00000011395 | Uncharacterized protein. (175 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa) |
| | FCGR2B | Uncharacterized protein. (313 aa) |
| | RAC1 | Uncharacterized protein. (212 aa) |
| | RPS6KA2 | Ribosomal protein S6 kinase. (758 aa) |
| | ENSCATP00000012908 | Ig-like domain-containing protein. (144 aa) |
| | TRAF6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa) |
| | ENSCATP00000013162 | Uncharacterized protein. (173 aa) |
| | PIP5K1B | Phosphatidylinositol-4-phosphate 5-kinase type 1 beta. (540 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa) |
| | MEFV | MEFV innate immuity regulator, pyrin. (783 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | CASP1 | Caspase 1; Belongs to the peptidase C14A family. (441 aa) |
| | ACTB | Uncharacterized protein. (375 aa) |
| | PKN1 | Protein kinase N1. (949 aa) |
| | GIT2 | GIT ArfGAP 2. (760 aa) |
| | ENSCATP00000015134 | Ig-like domain-containing protein. (173 aa) |
| | ARHGEF1 | Rho guanine nucleotide exchange factor 1. (968 aa) |
| | ENSCATP00000015421 | Ig-like domain-containing protein. (140 aa) |
| | ROCK1 | Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1337 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | MAP2K3 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa) |
| | ENSCATP00000017084 | Uncharacterized protein. (185 aa) |
| | RPS6KA1 | Ribosomal protein S6 kinase. (744 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa) |
| | VAV1 | Vav guanine nucleotide exchange factor 1. (856 aa) |
| | PKN2 | Protein kinase N2. (983 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | PIP5K1A | Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | ENSCATP00000019657 | Uncharacterized protein; Belongs to the actin family. (368 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | FCGR2A | Uncharacterized protein. (317 aa) |
| | PIP5K1C | Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (700 aa) |
| | LPXN | Leupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (386 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (367 aa) |
| | ACTR3 | Actin related protein 3; Belongs to the actin family. (418 aa) |
| | FN1 | Fibronectin 1. (2477 aa) |
| | CDC42 | Uncharacterized protein. (191 aa) |
| | LAT | Linker for activation of T cells. (270 aa) |
| | LIMK1 | LIM domain kinase 1. (672 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (440 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa) |
| | CD8B | Ig-like domain-containing protein. (213 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa) |
| | ARHGEF7 | Rho guanine nucleotide exchange factor 7. (804 aa) |
| | DOCK1 | Dedicator of cytokinesis 1; Belongs to the DOCK family. (1886 aa) |
| | PIK3R2 | Uncharacterized protein. (624 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa) |
| | ACTL8 | Actin like 8; Belongs to the actin family. (386 aa) |
| | ARHGEF12 | Rho guanine nucleotide exchange factor 12. (1544 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | ACTR2 | Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa) |
| | RPS6KA3 | Ribosomal protein S6 kinase. (732 aa) |
| | FYB1 | FYN binding protein 1. (839 aa) |
| | VAV2 | Vav guanine nucleotide exchange factor 2. (868 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase regulatory subunit 3. (461 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | TRAC | T cell receptor alpha constant. (110 aa) |
| | ENSCATP00000028696 | Ig-like domain-containing protein. (133 aa) |
| | NFATC3 | Nuclear factor of activated T cells 3. (1064 aa) |
| | TICAM1 | Toll like receptor adaptor molecule 1. (519 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (344 aa) |
| | CD4 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (462 aa) |
| | BCAR1 | BCAR1 scaffold protein, Cas family member. (916 aa) |
| | ZAP70 | Tyrosine-protein kinase. (619 aa) |
| | ITGB1 | Integrin beta; Belongs to the integrin beta chain family. (801 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | ENSCATP00000032953 | PIPK domain-containing protein. (487 aa) |
| | WIPF2 | WAS/WASL interacting protein family member 2. (440 aa) |
| | WASL | WASP like actin nucleation promoting factor. (503 aa) |
| | CRKL | CRK like proto-oncogene, adaptor protein. (303 aa) |
| | LOC105579900 | Uncharacterized protein. (319 aa) |
| | IRF3 | Interferon regulatory factor 3. (422 aa) |
| | RAC2 | Rac family small GTPase 2. (192 aa) |
| | ELMO1 | Engulfment and cell motility 1. (727 aa) |
| | WIPF3 | WAS/WASL interacting protein family member 3. (486 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (550 aa) |
| | NFKBIA | NFKB inhibitor alpha. (317 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (214 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (416 aa) |
| | ENSCATP00000037667 | Protein kinase domain-containing protein. (365 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | CRK | CRK proto-oncogene, adaptor protein. (304 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | BAIAP2 | BAI1 associated protein 2. (561 aa) |
| | TRBV10-1 | T cell receptor beta variable 10-1(gene/pseudogene). (131 aa) |
| | ENSCATP00000039367 | Uncharacterized protein. (360 aa) |
| | TRBV11-1 | T cell receptor beta variable 11-1. (142 aa) |
| | NFATC2 | Nuclear factor of activated T cells 2. (921 aa) |
| | LOC105573641 | Uncharacterized protein; Belongs to the actin family. (323 aa) |
| | ROCK2 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (474 aa) |
| | CCL2 | C-C motif chemokine. (99 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | ACTR3B | Actin related protein 3B; Belongs to the actin family. (418 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | ENSCATP00000042801 | Uncharacterized protein. (136 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (586 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa) |
