STRINGSTRING
GNAO1 GNAO1 IL10RA IL10RA LAMA2 LAMA2 NFKB1 NFKB1 HLA-DRA HLA-DRA LAMB3 LAMB3 RELA RELA CCR5 CCR5 PPIF PPIF JAK1 JAK1 PIK3CG PIK3CG LOC105600305 LOC105600305 LAMA3 LAMA3 BIRC2 BIRC2 ENSCATP00000032552 ENSCATP00000032552 STAT1 STAT1 AKT2 AKT2 ENSCATP00000031565 ENSCATP00000031565 ITGB1 ITGB1 PPP1R14B PPP1R14B HLA-DPB1 HLA-DPB1 HSPA2 HSPA2 ITGA6 ITGA6 CASP8 CASP8 IL10 IL10 LOC105576724 LOC105576724 LOC105571822 LOC105571822 LOC105575013 LOC105575013 CD40LG CD40LG LAMB4 LAMB4 LY96 LY96 HSPA8 HSPA8 IRAK4 IRAK4 IL12B IL12B LAMC2 LAMC2 HLA-DOA HLA-DOA ENSCATP00000024481 ENSCATP00000024481 TAB1 TAB1 LAMA4 LAMA4 NOS2 NOS2 ENSCATP00000022722 ENSCATP00000022722 LOC105600307 LOC105600307 IFNG IFNG ENSCATP00000022027 ENSCATP00000022027 LOC105576725 LOC105576725 BCL2L1 BCL2L1 TNFRSF1A TNFRSF1A MAPK12 MAPK12 PIK3R6 PIK3R6 MAPK9 MAPK9 AKT3 AKT3 LOC105572981 LOC105572981 ENSCATP00000019466 ENSCATP00000019466 LOC105575605 LOC105575605 GNAI1 GNAI1 IKBKB IKBKB LAMC3 LAMC3 BAD BAD PDPK1 PDPK1 ENSCATP00000018187 ENSCATP00000018187 STAT3 STAT3 LAMA1 LAMA1 MAP2K3 MAP2K3 TAB2 TAB2 MAPK1 MAPK1 CIITA CIITA IL10RB IL10RB ENSCATP00000014761 ENSCATP00000014761 HSPA6 HSPA6 LOC105575604 LOC105575604 GNAI3 GNAI3 IKBKG IKBKG HLA-DMA HLA-DMA TRAF6 TRAF6 TGFB2 TGFB2 HLA-DQB1 HLA-DQB1 ALOX5 ALOX5 MAPK3 MAPK3 XIAP XIAP CASP3 CASP3 ENSCATP00000010103 ENSCATP00000010103 MAPK11 MAPK11 TGFB1 TGFB1 BIRC3 BIRC3 CD40 CD40 TGFB3 TGFB3 JAK2 JAK2 HLA-DPA1 HLA-DPA1 LOC105575006 LOC105575006 IFNGR2 IFNGR2 TLR2 TLR2 HSPA1L HSPA1L LOC105589984 LOC105589984 MAPK13 MAPK13 AKT1 AKT1 LOC105588083 LOC105588083 LAMB1 LAMB1 CASP9 CASP9 LAMA5 LAMA5 C7orf31 C7orf31 SOCS1 SOCS1 MAPK8 MAPK8 ENSCATP00000001452 ENSCATP00000001452 ENSCATP00000001293 ENSCATP00000001293 LOC105595720 LOC105595720 ENSCATP00000001099 ENSCATP00000001099 TNF TNF TYK2 TYK2 LOC105575603 LOC105575603 ENSCATP00000000152 ENSCATP00000000152 NFKBIA NFKBIA IL12A IL12A ENSCATP00000034919 ENSCATP00000034919 IRGM IRGM ENSCATP00000038453 ENSCATP00000038453 MAPK14 MAPK14 PIK3R5 PIK3R5 LAMC1 LAMC1 LDLR LDLR LOC105571593 LOC105571593 NFKBIB NFKBIB ENSCATP00000041581 ENSCATP00000041581 TLR4 TLR4 LOC105583891 LOC105583891 GNAI2 GNAI2 MAPK10 MAPK10 CHUK CHUK MAP3K7 MAP3K7 BCL2 BCL2 MAP2K6 MAP2K6 MYD88 MYD88 IRAK1 IRAK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNAO1G protein subunit alpha o1. (354 aa)
IL10RAInterleukin 10 receptor subunit alpha. (576 aa)
LAMA2Laminin subunit alpha 2. (3053 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
RELARELA proto-oncogene, NF-kB subunit. (550 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (379 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (211 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
LOC105600305Ig-like domain-containing protein; Belongs to the MHC class II family. (219 aa)
LAMA3Laminin subunit alpha 3. (3333 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
ENSCATP00000032552Cytochrome c domain-containing protein; Belongs to the cytochrome c family. (109 aa)
STAT1Signal transducer and activator of transcription. (780 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSCATP00000031565Uncharacterized protein. (357 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
PPP1R14BUncharacterized protein. (207 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (602 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (515 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
LOC105576724Ig-like domain-containing protein. (283 aa)
LOC105571822Uncharacterized protein; Belongs to the heat shock protein 70 family. (534 aa)
LOC105575013Ig-like domain-containing protein. (273 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (261 aa)
LAMB4Laminin subunit beta 4. (1763 aa)
LY96Lymphocyte antigen 96. (160 aa)
HSPA8Uncharacterized protein. (129 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (328 aa)
LAMC2Laminin subunit gamma 2. (1193 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (298 aa)
ENSCATP00000024481Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (95 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
LAMA4Laminin subunit alpha 4. (1823 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1152 aa)
ENSCATP00000022722Uncharacterized protein; Belongs to the heat shock protein 70 family. (578 aa)
LOC105600307Ig-like domain-containing protein. (268 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
ENSCATP00000022027Uncharacterized protein; Belongs to the heat shock protein 70 family. (594 aa)
LOC105576725Ig-like domain-containing protein. (283 aa)
BCL2L1BCL2 like 1. (233 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (754 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC105572981Uncharacterized protein. (132 aa)
ENSCATP00000019466Uncharacterized protein; Belongs to the heat shock protein 70 family. (621 aa)
LOC105575605Ig-like domain-containing protein. (263 aa)
GNAI1G protein subunit alpha i1. (330 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
LAMC3Laminin subunit gamma 3. (1468 aa)
BADBCL2 associated agonist of cell death. (167 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (534 aa)
ENSCATP00000018187Ig-like domain-containing protein. (265 aa)
STAT3Signal transducer and activator of transcription. (777 aa)
LAMA1Laminin subunit alpha 1. (3079 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CIITAClass II major histocompatibility complex transactivator. (1207 aa)
IL10RBInterleukin 10 receptor subunit beta. (325 aa)
ENSCATP00000014761Ig-like domain-containing protein. (262 aa)
HSPA6Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. (605 aa)
LOC105575604Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
GNAI3G protein subunit alpha i3. (354 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (290 aa)
TRAF6TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 1. (284 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
ENSCATP00000010103Ig-like domain-containing protein. (273 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
CD40CD40 molecule. (278 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
JAK2Tyrosine-protein kinase. (1137 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
LOC105575006Ig-like domain-containing protein. (263 aa)
IFNGR2Interferon gamma receptor 2. (340 aa)
TLR2Toll-like receptor. (784 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
LOC105589984Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC105588083Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LAMB1Laminin subunit beta 1. (1810 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (416 aa)
LAMA5Laminin subunit alpha 5. (3673 aa)
C7orf31Chromosome 7 open reading frame 31. (590 aa)
SOCS1Suppressor of cytokine signaling 1. (213 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
ENSCATP00000001452Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (98 aa)
ENSCATP00000001293Uncharacterized protein; Belongs to the heat shock protein 70 family. (604 aa)
LOC105595720Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSCATP00000001099Ig-like domain-containing protein. (272 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TYK2Tyrosine-protein kinase. (1164 aa)
LOC105575603Ig-like domain-containing protein. (284 aa)
ENSCATP00000000152Uncharacterized protein. (64 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
ENSCATP00000034919Ig-like domain-containing protein. (264 aa)
IRGMImmunity related GTPase M. (159 aa)
ENSCATP00000038453Uncharacterized protein; Belongs to the peptidase C14A family. (262 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (880 aa)
LAMC1Laminin subunit gamma 1. (1598 aa)
LDLRLow density lipoprotein receptor. (764 aa)
LOC105571593Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
ENSCATP00000041581Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
LOC105583891Ig-like domain-containing protein. (339 aa)
GNAI2G protein subunit alpha i2. (355 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (586 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (721 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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