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| | ENSCATP00000041581 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa) |
| | ENSCATP00000042953 | IRF tryptophan pentad repeat domain-containing protein. (50 aa) |
| | EIF2S1 | Eukaryotic translation initiation factor 2 subunit alpha. (315 aa) |
| | IFIT1B | Interferon induced protein with tetratricopeptide repeats 1B. (474 aa) |
| | CLDN11 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | PSME3 | Proteasome activator subunit 3. (265 aa) |
| | IRF9 | Uncharacterized protein. (195 aa) |
| | EIF2AK4 | Eukaryotic translation initiation factor 2 alpha kinase 4. (1649 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | GRB2 | Growth factor receptor bound protein 2. (217 aa) |
| | LOC105571593 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | ENSCATP00000040576 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (196 aa) |
| | FAS | Tumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). (331 aa) |
| | YWHAH | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa) |
| | YWHAE | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa) |
| | LDLR | Low density lipoprotein receptor. (764 aa) |
| | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (586 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1327 aa) |
| | ENSCATP00000038535 | E2F_CC-MB domain-containing protein. (193 aa) |
| | ENSCATP00000038453 | Uncharacterized protein; Belongs to the peptidase C14A family. (262 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | ENSCATP00000037714 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (232 aa) |
| | ENSCATP00000037667 | Protein kinase domain-containing protein. (365 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa) |
| | NFKBIA | NFKB inhibitor alpha. (317 aa) |
| | JAK1 | Tyrosine-protein kinase. (1159 aa) |
| | OAS2 | 2'-5'-oligoadenylate synthetase 2. (718 aa) |
| | YWHAB | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (550 aa) |
| | IFIT5 | Interferon induced protein with tetratricopeptide repeats 5. (482 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | DDX58 | DExD/H-box helicase 58. (925 aa) |
| | STAT2 | Signal transducer and activator of transcription. (852 aa) |
| | IRF3 | Interferon regulatory factor 3. (422 aa) |
| | PPP2R1A | Protein phosphatase 2 scaffold subunit Aalpha. (589 aa) |
| | PPP2R2D | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa) |
| | E2F3 | E2F transcription factor 3. (467 aa) |
| | CD81 | Tetraspanin. (269 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1210 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase. (309 aa) |
| | E2F1 | E2F transcription factor 1. (437 aa) |
| | ENSCATP00000032552 | Cytochrome c domain-containing protein; Belongs to the cytochrome c family. (109 aa) |
| | STAT1 | Signal transducer and activator of transcription. (780 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa) |
| | ENSCATP00000031894 | Uncharacterized protein. (39 aa) |
| | YWHAG | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa) |
| | RNASEL | Ribonuclease L. (741 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (211 aa) |
| | ENSCATP00000030836 | Uncharacterized protein. (149 aa) |
| | OAS1 | 2'-5'-oligoadenylate synthetase 1. (452 aa) |
| | ENSCATP00000030673 | Uncharacterized protein. (652 aa) |
| | PPP1R14B | Uncharacterized protein. (207 aa) |
| | IFNAR1 | Interferon alpha and beta receptor subunit 1. (489 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (344 aa) |
| | TICAM1 | Toll like receptor adaptor molecule 1. (519 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa) |
| | PPARA | Peroxisome proliferator activated receptor alpha. (511 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | PPP2R2A | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa) |
| | ENSCATP00000027386 | Uncharacterized protein. (109 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase regulatory subunit 3. (461 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (515 aa) |
| | CSDE1 | Cold shock domain containing E1. (844 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa) |
| | OCLN | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (505 aa) |
| | EIF2AK2 | Eukaryotic translation initiation factor 2 alpha kinase 2. (551 aa) |
| | MX1 | MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (627 aa) |
| | CLDN1 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) |
| | MX2 | MX dynamin like GTPase 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (715 aa) |
| | RAF1 | Uncharacterized protein. (668 aa) |
| | CXCL10 | C-X-C motif chemokine. (98 aa) |
| | ENSCATP00000024481 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (95 aa) |
| | EIF2AK1 | Eukaryotic translation initiation factor 2 alpha kinase 1. (663 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa) |
| | PIK3R2 | Uncharacterized protein. (624 aa) |
| | ENSCATP00000023795 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (238 aa) |
| | CLDN18 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa) |
| | OAS3 | 2'-5'-oligoadenylate synthetase 3. (1088 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa) |
| | CLDN7 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (440 aa) |
| | CTNNB1 | Catenin beta 1. (781 aa) |
| | FASLG | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (455 aa) |
| | BRAF | B-Raf proto-oncogene, serine/threonine kinase. (762 aa) |
| | RXRA | Retinoid X receptor alpha. (630 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (693 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | LOC105572981 | Uncharacterized protein. (132 aa) |
| | CLDN15 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (228 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | BAD | BCL2 associated agonist of cell death. (167 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | CLDN16 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (235 aa) |
| | STAT3 | Signal transducer and activator of transcription. (777 aa) |
| | BID | BH3 interacting domain death agonist. (244 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | NR1H3 | Nuclear receptor subfamily 1 group H member 3. (466 aa) |
| | CFLAR | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa) |
| | EIF3E | Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (496 aa) |
| | MAVS | Mitochondrial antiviral signaling protein. (541 aa) |
| | IRF7 | Interferon regulatory factor 7. (517 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa) |
| | TRAF6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa) |
| | ENSCATP00000012945 | Protein kinase domain-containing protein. (101 aa) |
| | ENSCATP00000012820 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (208 aa) |
| | ARAF | A-Raf proto-oncogene, serine/threonine kinase. (606 aa) |
| | RSAD2 | Radical S-adenosyl methionine domain containing 2. (360 aa) |
| | TRADD | TNFRSF1A associated via death domain. (308 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | E2F2 | E2F transcription factor 2. (437 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa) |
| | TLR3 | Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa) |
| | PPP2R2C | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa) |
| | ENSCATP00000010452 | Uncharacterized protein. (596 aa) |
| | CASP3 | Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa) |
| | ENSCATP00000009728 | eIF3_N domain-containing protein; Belongs to the eIF-3 subunit E family. (205 aa) |
| | PPP2R1B | Protein phosphatase 2 scaffold subunit Abeta. (667 aa) |
| | SCARB1 | Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa) |
| | YWHAZ | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa) |
| | YWHAQ | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (248 aa) |
| | IFNA6 | Interferon alpha 6. (190 aa) |
| | CLDN8 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa) |
| | CLDN2 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa) |
| | IFIT3 | Interferon induced protein with tetratricopeptide repeats 3. (487 aa) |
| | LOC105589984 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | CLDN22 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | LOC105588083 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | CLDN3 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa) |
| | IFNB1 | Interferon beta 1. (187 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (571 aa) |
| | IFNAR2 | Interfer-bind domain-containing protein. (419 aa) |
| | RB1 | RB transcriptional corepressor 1. (926 aa) |
| | CLDN5 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa) |
| | CLDN4 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (416 aa) |
| | CDK4 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) |
| | CLDN10 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (228 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (164 aa) |
| | CLDN19 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa) |
| | ERAS | ES cell expressed Ras. (233 aa) |
| | CLDN14 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (236 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (203 aa) |
| | ENSCATP00000004066 | Uncharacterized protein. (189 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa) |
| | ENSCATP00000003364 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (217 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (309 aa) |
| | PIAS1 | Protein inhibitor of activated STAT 1. (651 aa) |
| | C7orf31 | Chromosome 7 open reading frame 31. (590 aa) |
| | ENSCATP00000001452 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (98 aa) |
| | LOC105595720 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | CLDN24 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa) |
| | TNF | Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa) |
| | SOCS3 | Suppressor of cytokine signaling 3. (225 aa) |
| | TYK2 | Tyrosine-protein kinase. (1164 aa) |
| | EIF2AK3 | Eukaryotic translation initiation factor 2 alpha kinase 3. (964 aa) |
| | ENSCATP00000000152 | Uncharacterized protein. (64 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa) |
| | CLDN9 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa) |
