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| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (328 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (404 aa) |
| | CD3D | CD3d molecule. (171 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | BBC3 | BCL2 binding component 3. (261 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (721 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa) |
| | EIF2S1 | Eukaryotic translation initiation factor 2 subunit alpha. (315 aa) |
| | BCL2 | BCL2 apoptosis regulator. (239 aa) |
| | ENSCATP00000042953 | IRF tryptophan pentad repeat domain-containing protein. (50 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (586 aa) |
| | TLR7 | Toll-like receptor 7; Belongs to the Toll-like receptor family. (1049 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | EIF2AK4 | Eukaryotic translation initiation factor 2 alpha kinase 4. (1649 aa) |
| | RCHY1 | Ring finger and CHY zinc finger domain containing 1. (261 aa) |
| | CSNK2A1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (474 aa) |
| | IRF9 | Uncharacterized protein. (195 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa) |
| | CD3E | CD3e molecule. (198 aa) |
| | ENSCATP00000041581 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa) |
| | SLAMF1 | Signaling lymphocytic activation molecule family member 1. (356 aa) |
| | NFKBIB | NFKB inhibitor beta. (356 aa) |
| | LOC105571593 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | CD28 | CD28 molecule. (234 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | FAS | Tumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). (331 aa) |
| | TLR9 | TIR domain-containing protein. (1033 aa) |
| | TRBV11-1 | T cell receptor beta variable 11-1. (142 aa) |
| | TRBV10-1 | T cell receptor beta variable 10-1(gene/pseudogene). (131 aa) |
| | CD3G | CD3g molecule. (181 aa) |
| | CLEC4G | C-type lectin domain family 4 member G. (293 aa) |
| | ENSCATP00000038453 | Uncharacterized protein; Belongs to the peptidase C14A family. (262 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa) |
| | CCND3 | Cyclin D3; Belongs to the cyclin family. (292 aa) |
| | TNFAIP3 | TNF alpha induced protein 3. (790 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (214 aa) |
| | NFKBIA | NFKB inhibitor alpha. (317 aa) |
| | JAK1 | Tyrosine-protein kinase. (1159 aa) |
| | OAS2 | 2'-5'-oligoadenylate synthetase 2. (718 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (550 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (271 aa) |
| | CD46 | CD46 molecule. (399 aa) |
| | CSNK2B | Uncharacterized protein. (298 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | DDX58 | DExD/H-box helicase 58. (925 aa) |
| | STAT2 | Signal transducer and activator of transcription. (852 aa) |
| | IRF3 | Interferon regulatory factor 3. (422 aa) |
| | CD209 | CD209 molecule. (404 aa) |
| | CDKN1B | Cyclin dependent kinase inhibitor 1B. (198 aa) |
| | ENSCATP00000032552 | Cytochrome c domain-containing protein; Belongs to the cytochrome c family. (109 aa) |
| | STAT1 | Signal transducer and activator of transcription. (780 aa) |
| | IL2RB | Interleukin 2 receptor subunit beta. (551 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa) |
| | STAT5A | Signal transducer and activator of transcription. (794 aa) |
| | ENSCATP00000031565 | Uncharacterized protein. (357 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (211 aa) |
| | ENSCATP00000030836 | Uncharacterized protein. (149 aa) |
| | OAS1 | 2'-5'-oligoadenylate synthetase 1. (452 aa) |
| | PPP1R14B | Uncharacterized protein. (207 aa) |
| | IFNAR1 | Interferon alpha and beta receptor subunit 1. (489 aa) |
| | TP73 | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa) |
| | HSPA2 | Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (602 aa) |
| | RACK1 | Receptor for activated C kinase 1. (393 aa) |
| | ENSCATP00000028696 | Ig-like domain-containing protein. (133 aa) |
| | TRAC | T cell receptor alpha constant. (110 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase regulatory subunit 3. (461 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (515 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (410 aa) |
| | EIF2AK2 | Eukaryotic translation initiation factor 2 alpha kinase 2. (551 aa) |
| | MX1 | MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (627 aa) |
| | CCND2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa) |
| | LOC105571822 | Uncharacterized protein; Belongs to the heat shock protein 70 family. (534 aa) |
| | HSPA8 | Uncharacterized protein. (129 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) |
| | MX2 | MX dynamin like GTPase 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (715 aa) |
| | ENSCATP00000024481 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (95 aa) |
| | EIF2AK1 | Eukaryotic translation initiation factor 2 alpha kinase 1. (663 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa) |
| | PIK3R2 | Uncharacterized protein. (624 aa) |
| | LIMCH1 | LIM and calponin homology domains 1. (1467 aa) |
| | OAS3 | 2'-5'-oligoadenylate synthetase 3. (1088 aa) |
| | ENSCATP00000022722 | Uncharacterized protein; Belongs to the heat shock protein 70 family. (578 aa) |
| | MSN | Moesin. (577 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (440 aa) |
| | ENSCATP00000022027 | Uncharacterized protein; Belongs to the heat shock protein 70 family. (594 aa) |
| | BCL2L1 | BCL2 like 1. (233 aa) |
| | FASLG | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (693 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | LOC105572981 | Uncharacterized protein. (132 aa) |
| | ENSCATP00000019466 | Uncharacterized protein; Belongs to the heat shock protein 70 family. (621 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | BAD | BCL2 associated agonist of cell death. (167 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa) |
| | STAT3 | Signal transducer and activator of transcription. (777 aa) |
| | BID | BH3 interacting domain death agonist. (244 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | IL2RG | Fibronectin type-III domain-containing protein. (369 aa) |
| | IFIH1 | Interferon induced with helicase C domain 1. (1025 aa) |
| | MAVS | Mitochondrial antiviral signaling protein. (541 aa) |
| | IRF7 | Interferon regulatory factor 7. (517 aa) |
| | HSPA6 | Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. (605 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa) |
| | TRAF6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa) |
| | ENSCATP00000012945 | Protein kinase domain-containing protein. (101 aa) |
| | TRADD | TNFRSF1A associated via death domain. (308 aa) |
| | CASP3 | Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa) |
| | ADAR | Adenosine deaminase RNA specific. (1316 aa) |
| | IFNA6 | Interferon alpha 6. (190 aa) |
| | CSNK2A2 | Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (350 aa) |
| | TLR2 | Toll-like receptor. (784 aa) |
| | JAK3 | Tyrosine-protein kinase. (1124 aa) |
| | HSPA1L | Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa) |
| | LOC105589984 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | LOC105588083 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | IL2RA | Interleukin 2 receptor subunit alpha. (272 aa) |
| | IFNB1 | Interferon beta 1. (187 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (571 aa) |
| | IFNAR2 | Interfer-bind domain-containing protein. (419 aa) |
| | RAB9A | RAB9A, member RAS oncogene family. (201 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (416 aa) |
| | CDK4 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (203 aa) |
| | ENSCATP00000004066 | Uncharacterized protein. (189 aa) |
| | STAT5B | Signal transducer and activator of transcription. (787 aa) |
| | C7orf31 | Chromosome 7 open reading frame 31. (590 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (384 aa) |
| | CBLB | Cbl proto-oncogene B. (1027 aa) |
| | ENSCATP00000001452 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (98 aa) |
| | ENSCATP00000001293 | Uncharacterized protein; Belongs to the heat shock protein 70 family. (604 aa) |
| | LOC105595720 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | TYK2 | Tyrosine-protein kinase. (1164 aa) |
| | EIF2AK3 | Eukaryotic translation initiation factor 2 alpha kinase 3. (964 aa) |
| | EIF3H | Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (351 aa) |
| | ENSCATP00000000152 | Uncharacterized protein. (64 aa) |
